Plain-spoken notes on the compounds we supply — what the literature shows, how to read a COA, and the protocols that protect your data. Cited, never hyped.
Methods & QC
“Metatrutide” circulates in grey-market peptide catalogues and forum threads as though it were an established compound with a defined structure. It is not. Searching…
Methods & QC
A Mars round trip outlasts most drug shelf lives. Why peptides degrade first in deep space, what on-demand synthesis could fix, and why verification…
Methods & QC
Gut proteases destroy peptides and the epithelium blocks them: oral bioavailability is usually under 1%. What SNAC, macrocycles and devices really change.
Immune
Mutant-KRAS peptide cancer vaccines, read honestly: the 2026 phase I colorectal trial, ELI-002 results, and why T-cell responses have rarely meant survival.
Metabolic & longevity
A 2026 state-of-play on MOTS-c: the narrow FDA advisory vote, the June 2026 stromal-cell study that complicates the story, and what the human evidence…
In the news
At the FDA's July 2026 compounding panel, six peptides passed and one failed: emideltide (DSIP). Why that single rejection is the most revealing vote…
Methods & QC
PeptiVerse, published in Nature Communications in July 2026, predicts peptide developability from sequence or SMILES. What it does, and what it cannot.
In the news
Samsung Biologics has bid CHF 1.46bn for Swiss peptide CDMO PolyPeptide. A sober look at what the deal says about manufacturing capacity, and what…
Metabolic & longevity
Survodutide's phase 3 body-composition substudy reported 34% less visceral fat and 63% less liver fat. What the lean-mass number does and doesn't show.
Metabolic & longevity
Petrelintide and amycretin put amylin receptor agonism to the test: less weight loss than incretins, far better GI tolerability. RUO reference overview.
In the news
Lilly's retatrutide passed TRIUMPH-2 and TRIUMPH-3 in July 2026 — but missed on cardiovascular events, and the FDA filing slipped to Q1 2027. An…
In the news
An FDA panel recommended six of seven peptides for the 503A compounding list on 23-24 July 2026. That is not approval. What the vote…
Occasional, considered notes on the compounds and the literature. No noise.
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