Plain-spoken notes on the compounds we supply — what the literature shows, how to read a COA, and the protocols that protect your data. Cited, never hyped.
Metabolic & longevity
Most GLP-1 receptor agonists activate the receptor’s two main signalling arms — cAMP production and β-arrestin recruitment — more or less together. Ecnoglutide (XW003)…
Metabolic & longevity
ATX-304 goes by a chemistry-lab name, but it began as O304, a compound built to activate every isoform of AMP-activated protein kinase (AMPK) at…
Metabolic & longevity
A 2026 state-of-play on MOTS-c: the narrow FDA advisory vote, the June 2026 stromal-cell study that complicates the story, and what the human evidence…
Metabolic & longevity
Survodutide's phase 3 body-composition substudy reported 34% less visceral fat and 63% less liver fat. What the lean-mass number does and doesn't show.
Metabolic & longevity
Petrelintide and amycretin put amylin receptor agonism to the test: less weight loss than incretins, far better GI tolerability. RUO reference overview.
Metabolic & longevity
A 2026 Copenhagen study reports MOTS-c improved intrinsic muscle mitochondrial quality in mice via PGC-1α and AMPK — without more mitochondria. RUO analysis.
Metabolic & longevity
Mitochondrial-derived peptides (MDPs) like humanin and MOTS-c are encoded inside mtDNA and act like hormones. What the cell, animal and human data actually show.
Metabolic & longevity
Exendin-4, the founding molecule of the GLP-1 drug class, was isolated from Gila monster venom by John Eng in 1992. The science-history behind the…
Metabolic & longevity
A deflationary scorecard of popular longevity compounds ranked by real human RCT evidence: rapamycin, metformin, NAD precursors, spermidine, urolithin A and more.
Metabolic & longevity
An evidence-anchored ranking of senolytics — Dasatinib+Quercetin, fisetin, navitoclax, FOXO4-DRI — showing what human and mouse data actually support, and where the field has…
Metabolic & longevity
BAM15 is a mitochondrial uncoupler studied in cell and rodent metabolic research. What it is, how it works, the evidence, and why it is…
Occasional, considered notes on the compounds and the literature. No noise.
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