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EloraTZP vs Retatrutide: What the Three Datasets Show In the news
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EloraTZP vs Retatrutide: What the Three Datasets Show

A Lilly slide shows 29% weight loss in 31 weeks with eloralintide plus tirzepatide. Only 3 of 12 had data, and it can't be compared with retatrutide's 28.3%.

Oct 2026 · 6 min read
ERR Agonist Evidence Atlas Metabolic & longevity

ERR Agonist Evidence Atlas

Explore 5 selected primary studies on the chemically distinct ERR agonists SLU-PP-332 and SLU-PP-915. Each record identifies the experimental model, reported finding and limits…

Sep 2026 · 5 min read
Does Semaglutide Slow Ageing? What the New Nature Study Actually Shows Metabolic & longevity

Does Semaglutide Slow Ageing? What the New Nature Study Actually Shows

Semaglutide started at 20 months extended median lifespan in female mice from 742 to 834 days and beat matched calorie restriction on memory, exploration…

Sep 2026 · 7 min read
What Is ALY688? The Peptide Built to Get Around Adiponectin’s Manufacturing Problem Metabolic & longevity

What Is ALY688? The Peptide Built to Get Around Adiponectin’s Manufacturing Problem

Adiponectin is one of the more interesting hormones in metabolic research: a fat-derived signal whose levels fall exactly when the body needs more of…

Aug 2026 · 10 min read
Ecnoglutide: A cAMP-Biased GLP-1 Agonist Approved in China, Not Yet in Europe or the US Metabolic & longevity

Ecnoglutide: A cAMP-Biased GLP-1 Agonist Approved in China, Not Yet in Europe or the US

Most GLP-1 receptor agonists activate the receptor’s two main signalling arms — cAMP production and β-arrestin recruitment — more or less together. Ecnoglutide (XW003)…

Aug 2026 · 8 min read
What Is ATX-304? The Small-Molecule AMPK Activator With a Mitochondrial Twist Metabolic & longevity

What Is ATX-304? The Small-Molecule AMPK Activator With a Mitochondrial Twist

ATX-304 goes by a chemistry-lab name, but it began as O304, a compound built to activate every isoform of AMP-activated protein kinase (AMPK) at…

Aug 2026 · 8 min read
MOTS-c Is Having a Moment. The Evidence Is More Complicated Than the Headlines. Metabolic & longevity

MOTS-c Is Having a Moment. The Evidence Is More Complicated Than the Headlines.

A 2026 state-of-play on MOTS-c: the narrow FDA advisory vote, the June 2026 stromal-cell study that complicates the story, and what the human evidence…

Aug 2026 · 8 min read
Losing Fat Without Losing Muscle: What the Survodutide Body-Composition Data Actually Show Metabolic & longevity

Losing Fat Without Losing Muscle: What the Survodutide Body-Composition Data Actually Show

Survodutide's phase 3 body-composition substudy reported 34% less visceral fat and 63% less liver fat. What the lean-mass number does and doesn't show.

Aug 2026 · 9 min read
After GLP-1, Amylin: The Obesity Drugs Betting on Tolerability Instead of Magnitude Metabolic & longevity

After GLP-1, Amylin: The Obesity Drugs Betting on Tolerability Instead of Magnitude

Petrelintide and amycretin put amylin receptor agonism to the test: less weight loss than incretins, far better GI tolerability. RUO reference overview.

Aug 2026 · 7 min read
New MOTS-c Study (2026): Better Muscle Mitochondrial Quality via PGC-1α and AMPK, Not More Mitochondria Metabolic & longevity

New MOTS-c Study (2026): Better Muscle Mitochondrial Quality via PGC-1α and AMPK, Not More Mitochondria

A 2026 Copenhagen study reports MOTS-c improved intrinsic muscle mitochondrial quality in mice via PGC-1α and AMPK — without more mitochondria. RUO analysis.

Jul 2026 · 6 min read
Your Mitochondria Secrete Hormones: The MOTS-c and Humanin Story Metabolic & longevity

Your Mitochondria Secrete Hormones: The MOTS-c and Humanin Story

Mitochondrial-derived peptides (MDPs) like humanin and MOTS-c are encoded inside mtDNA and act like hormones. What the cell, animal and human data actually show.

Jul 2026 · 6 min read
From Gila Monster Venom to GLP-1: The Lizard That Rewrote Metabolic Medicine Metabolic & longevity

From Gila Monster Venom to GLP-1: The Lizard That Rewrote Metabolic Medicine

Exendin-4, the founding molecule of the GLP-1 drug class, was isolated from Gila monster venom by John Eng in 1992. The science-history behind the…

Jul 2026 · 7 min read
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