Plain-spoken notes on the compounds we supply — what the literature shows, how to read a COA, and the protocols that protect your data. Cited, never hyped.
Metabolic & longevity
A naturally occurring polyamine that induces autophagy from yeast to mice, backed by striking mortality epidemiology — and undercut by randomised human trials that…
Metabolic & longevity
A small molecule made untrained mice run dramatically further. Two decades and several large human trials later, acadesine's record is a study in how…
Metabolic & longevity
Elamipretide is the most clinically advanced cardiolipin-targeting tetrapeptide ever tested — now an approved Barth-syndrome drug, yet with a trial record that is the…
Metabolic & longevity
Most research peptides suffer from thin, animal-only data. This GLP-1 receptor agonist has the opposite problem — and the gap between a licensed medicine…
Metabolic & longevity
Tirzepatide beat semaglutide head-to-head on weight loss in a randomised trial. Here is what the human data actually establish — and the hard line…
Metabolic & longevity
The same growth signalling that builds muscle is the one whose quieting extends lifespan in animals. An honest look at a paradox biology has…
Metabolic & longevity
MOTS-c is a 16-amino-acid peptide encoded inside the mitochondrial genome itself, studied as an exercise-responsive metabolic signal. The biology is genuinely striking — but…
Metabolic & longevity
NAD+ falls with age and an entire industry promises to refill it. But “raises NAD+” and “slows ageing” are two different claims — and…
Metabolic & longevity
The dream of a molecule that delivers a workout’s metabolic rewards without the workout is one of longevity’s most seductive ideas. Examined honestly, it…
Metabolic & longevity
NAD+ is the redox coenzyme every cell uses to make energy and to fuel its sirtuins and PARPs — and its levels fall with…
Metabolic & longevity
AOD-9604 is a synthetic fragment of human growth hormone, engineered to keep a fat-metabolising signal while shedding the growth. It became a famous “fat-burning…
Occasional, considered notes on the compounds and the literature. No noise.
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