ERR Agonist Evidence Atlas
Explore 5 selected primary studies on the chemically distinct ERR agonists SLU-PP-332 and SLU-PP-915. Each record identifies the experimental model, reported finding and limits of interpretation.
Curated starting set of five primary studies on two distinct ERR research compounds. This is not a systematic or exhaustive review. Summaries describe published research, not experiments performed by Condor Research.
Scope & method
Record counts describe this dataset only. A missing study or model is not evidence of absence from the literature.
Use the model, finding and limitation fields together. Source verification dates describe this dataset’s checks; they do not establish an exhaustive literature cutoff.
Start with identity
Related names and shared receptor targets do not make compounds interchangeable.
SLU-PP-332
Distinct small-molecule pan-ERR research agonist; not SLU-PP-915.
Identity sources: PMID 36988910 · PMID 37961903
SLU-PP-915
- Name
- 10s
- Scope
- Compound label in Hampton et al. 2023 only
- Source pmid
- 37421886
Chemically distinct from SLU-PP-332. The discovery abstract explicitly identifies SLU-PP-915 as compound 10s.
Identity sources: PMID 37421886 · PMID 37961903 · PMID 41421047
Follow the evidence
Each record links a reported finding to its experimental context and source. Studies are listed by publication year, most recent first.
2026 · Study permalink
An orally active estrogen receptor-related receptor agonist, SLU-PP-915, enhances aerobic exercise capacity
Preclinical mouse exercise-capacity experiments with exposure-adjusted comparison.
SLU-PP-915 was reported to retain exercise-capacity activity after oral administration in the animal experiments. The authors compared it with SLU-PP-332 and reported similar activity under the tested, exposure-adjusted conditions.
This comparison does not establish human oral bioavailability, safety, clinical efficacy or universal superiority. Exposure-adjusted experimental comparisons are not instructions for use.
Read the source · PMID 41421047 · DOI 10.1016/j.jpet.2025.103787
Source verification
- Checked on
- 2026-09-15
- Source type
- Primary research
- Verification scope
- Published abstract and bibliographic record; publisher full text was inaccessible during this check.
- Source location
- Abstract
- Bibliographic record
- Source record
2024 · Study permalink
Novel pan-ERR agonists ameliorate heart failure through enhancing cardiac fatty acid metabolism and mitochondrial function
Mouse pressure-overload model, neonatal rat ventricular myocytes and genetic dependency experiments.
Both structurally distinct compounds changed cardiac metabolic programs and functional endpoints in the pressure-overload model. Genetic experiments identified ERRγ as a major mediator of the observed response.
Results in this experimental disease model do not establish a cardiac treatment in humans. Findings on both compounds do not make their chemistry, exposure or performance interchangeable.
Read the source · PMID 37961903 · DOI 10.1161/CIRCULATIONAHA.123.066542
Source verification
- Checked on
- 2026-09-15
- Source type
- Primary research
- Verification scope
- PMC author manuscript: abstract, methods and introduction inspected; no independent effect-size reanalysis.
- Source location
- Abstract; Methods: Animals and Neonatal rat ventricular myocytes
- Bibliographic record
- Source record
2024 · Study permalink
A Synthetic ERR Agonist Alleviates Metabolic Syndrome
Diet-induced obese and ob/ob mouse models.
The study reported increased energy expenditure and fatty acid oxidation, reduced fat-mass accumulation and changes in insulin sensitivity in the investigated mouse models.
These are model-specific preclinical findings, not evidence of weight-management efficacy or safety in humans. They cannot be reassigned to SLU-PP-915.
Read the source · PMID 37739806 · DOI 10.1124/jpet.123.001733
Source verification
- Checked on
- 2026-09-15
- Source type
- Primary research
- Verification scope
- Published abstract, publisher record and bibliographic record; no independent effect-size reanalysis.
- Source location
- Abstract
- Bibliographic record
- Source record
2023 · Study permalink
Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915
Cell-based receptor assays, protein-binding experiments, microsomal assays and in vitro/in vivo gene-expression experiments.
The authors identified SLU-PP-915 as compound 10s in a chemically distinct series of pan-ERR agonists. The reported gene-expression experiments showed induction of ERR target genes.
This discovery study supports chemical-probe characterization. It does not establish clinical outcomes or a universal potency ranking against SLU-PP-332; assay conditions matter.
Read the source · PMID 37421886 · DOI 10.1016/j.ejmech.2023.115582
Source verification
- Checked on
- 2026-09-15
- Source type
- Primary research
- Verification scope
- Published abstract and bibliographic record; 10s identity is stated explicitly in the abstract. Model details are deliberately limited to the accessible abstract.
- Source location
- Abstract
- Bibliographic record
- Source record
2023 · Study permalink
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity
Skeletal muscle cell line and mouse exercise experiments.
SLU-PP-332 activated all three ERR isoforms in the reported assays. The researchers observed increased cellular respiration, oxidative muscle fibers and exercise endurance; the mouse endurance response depended on ERRα.
Cellular and mouse endpoints do not establish human performance effects, clinical efficacy or safety. ERRα dependence in this experiment does not establish identical dependence in every tissue.
Read the source · PMID 36988910 · DOI 10.1021/acschembio.2c00720
Source verification
- Checked on
- 2026-09-15
- Source type
- Primary research
- Verification scope
- Published abstract and bibliographic record; detailed full-text extraction was not available.
- Source location
- Abstract
- Bibliographic record
- Source record
Reading across studies
- Shared ERR-family activity does not imply chemical identity.
- The selected studies contain cellular and animal evidence; they do not establish human efficacy or safety. This statement describes this selected set, not an exhaustive search for human studies.
- Mouse exercise, metabolic and pressure-overload endpoints answer different research questions and should not be pooled into a single efficacy score.
- Publication year uses the journal issue year. The 2026 exercise-capacity article was first published online on 2025-12-01.
- No potency league table, CAS number, chemical formula, dosing protocol or claim about product batches is inferred from this dataset.
Continue the research
- SLU-PP-915: identity and research context
- SLU-PP-915 and SLU-PP-332: the detailed comparison
- Download this version’s structured evidence records (JSON)
Research Use Only. This resource discusses experimental research and does not provide guidance for human use.
The downloadable dataset contains the identities, study summaries, limitations and source identifiers shown here. When citing this atlas, include its title, version, source-check date and the relevant study permalink. Cite the original publication for experimental results.