A naturally occurring polyamine that induces autophagy from yeast to mice, backed by striking mortality epidemiology — and undercut by randomised human trials that keep underdelivering. An honest scorecard.
A small molecule made untrained mice run dramatically further. Two decades and several large human trials later, acadesine’s record is a study in how rodent spectacle and clinical reality diverge.
Elamipretide is the most clinically advanced cardiolipin-targeting tetrapeptide ever tested — now an approved Barth-syndrome drug, yet with a trial record that is the field’s sharpest cautionary tale.
Most research peptides suffer from thin, animal-only data. This GLP-1 receptor agonist has the opposite problem — and the gap between a licensed medicine and a reference vial is the whole story.
Tirzepatide beat semaglutide head-to-head on weight loss in a randomised trial. Here is what the human data actually establish — and the hard line between a licensed medicine and a research-grade reference compound.
The same growth signalling that builds muscle is the one whose quieting extends lifespan in animals. An honest look at a paradox biology has not cleanly resolved in humans — and at the research tools used to probe it.
MOTS-c is a 16-amino-acid peptide encoded inside the mitochondrial genome itself, studied as an exercise-responsive metabolic signal. The biology is genuinely striking — but the evidence is overwhelmingly preclinical.
NAD+ falls with age and an entire industry promises to refill it. But “raises NAD+” and “slows ageing” are two different claims — and in humans, only the first is well supported.
The dream of a molecule that delivers a workout’s metabolic rewards without the workout is one of longevity’s most seductive ideas. Examined honestly, it lives almost entirely in mice — promising biology, marketing far ahead of the clinic.
NAD+ is the redox coenzyme every cell uses to make energy and to fuel its sirtuins and PARPs — and its levels fall with age. Here is what the science actually shows, and what it does not.
Cookies
We use strictly necessary cookies to run the store. With your consent we also use analytics (order attribution) and marketing (Omnisend) cookies. Read our Cookie Policy.