Metabolic & longevity

Explore 5 selected primary studies on the chemically distinct ERR agonists SLU-PP-332 and SLU-PP-915. Each record identifies the experimental model, reported finding and limits of interpretation.

Semaglutide started at 20 months extended median lifespan in female mice from 742 to 834 days and beat matched calorie restriction on memory, exploration and glucose control. One strain, one sex, one laboratory, and no human evidence.

Adiponectin is one of the more interesting hormones in metabolic research: a fat-derived signal whose levels fall exactly when the body needs more of it, in obesity and insulin resistance.1 For two decades, turning that biology into a drug has run into the same obstacle — the native hormone is a large, heavily modified, multimeric…

Most GLP-1 receptor agonists activate the receptor’s two main signalling arms — cAMP production and β-arrestin recruitment — more or less together. Ecnoglutide (XW003) was engineered to separate them, favouring cAMP while limiting β-arrestin recruitment, the pathway most associated with receptor desensitisation. That design choice, and a 2026 regulatory approval in China, have made ecnoglutide…

ATX-304 goes by a chemistry-lab name, but it began as O304, a compound built to activate every isoform of AMP-activated protein kinase (AMPK) at once — the enzyme that senses when a cell is short on energy and tells it to start burning fuel. It is not a peptide; it is a small molecule, taken…

A 2026 state-of-play on MOTS-c: the narrow FDA advisory vote, the June 2026 stromal-cell study that complicates the story, and what the human evidence shows.

Survodutide’s phase 3 body-composition substudy reported 34% less visceral fat and 63% less liver fat. What the lean-mass number does and doesn’t show.

Petrelintide and amycretin put amylin receptor agonism to the test: less weight loss than incretins, far better GI tolerability. RUO reference overview.

A 2026 Copenhagen study reports MOTS-c improved intrinsic muscle mitochondrial quality in mice via PGC-1α and AMPK — without more mitochondria. RUO analysis.

Mitochondrial-derived peptides (MDPs) like humanin and MOTS-c are encoded inside mtDNA and act like hormones. What the cell, animal and human data actually show.