Metabolic & longevity

Exendin-4, the founding molecule of the GLP-1 drug class, was isolated from Gila monster venom by John Eng in 1992. The science-history behind the lizard peptide.

A deflationary scorecard of popular longevity compounds ranked by real human RCT evidence: rapamycin, metformin, NAD precursors, spermidine, urolithin A and more.

An evidence-anchored ranking of senolytics — Dasatinib+Quercetin, fisetin, navitoclax, FOXO4-DRI — showing what human and mouse data actually support, and where the field has failed.

BAM15 is a mitochondrial uncoupler studied in cell and rodent metabolic research. What it is, how it works, the evidence, and why it is compared to DNP.

Cagrilintide (AM833) is a long-acting amylin analogue and dual amylin/calcitonin receptor agonist. Its chemistry, receptor pharmacology, and trial evidence, RUO.

Humanin is a 24-amino-acid mitochondrial-derived peptide encoded in the 16S rRNA region, studied in ageing, apoptosis and metabolic biology. RUO overview.

Adipotide (FTPP / Prohibitin-TP01) is a chimeric peptidomimetic studied for targeting white-fat blood vessels. What the primate and mouse data actually show — RUO.

FOXO4-DRI is a D-retro-inverso senolytic peptide that disrupted the FOXO4-p53 interaction and cleared senescent cells in aged mice. What the research actually shows.

SLU-PP-915 is a synthetic, orally bioavailable pan-ERR agonist. What the mouse and in-vitro literature actually shows, and where the evidence is still thin.

A naturally occurring polyamine that induces autophagy from yeast to mice, backed by striking mortality epidemiology — and undercut by randomised human trials that keep underdelivering. An honest scorecard.