Plain-spoken notes on the compounds we supply — what the literature shows, how to read a COA, and the protocols that protect your data. Cited, never hyped.
Regulation
FDA revised 17 product-specific guidances for generic peptides and withdrew its 2021 synthetic peptide guidance. The five areas it targeted explain why the same…
Methods & QC
In one month: computationally designed antimicrobial nanopores that work in mice, an engineered peptide nanopore that detects single α-synuclein species, and LLM-assisted design of…
In the news
On 28 August 2026 FDA approved Mimrylo (rusfertide) for polycythemia vera — the first hepcidin-mimetic peptide medicine. The mechanism is iron restriction, and it…
In the news
Avexitide is a GLP-1 receptor antagonist — the same target as semaglutide, the opposite direction. In August 2026 it cut severe hypoglycaemic events by…
Methods & QC
Human amylin forms amyloid fibrils in the pancreas, which is why it was undruggable. Three proline substitutions borrowed from rat amylin fixed it. And…
Methods & QC
Novo Nordisk ran one peptide two ways in the same trial network. The top oral arm received about nine times more drug per week…
In the news
A listed telehealth company with 2.9 million subscribers is preparing to sell peptides, and is already running stability testing on BPC-157. What that says…
Regulation
FDA set aside an RUO disclaimer and ruled on the rest of the website instead. Lilly then asked payment processors and carriers to cut…
Search for the two-peptide blend of GHK-Cu and KPV and you will not find one product. You will find at least eight different names…
Metabolic & longevity
Most GLP-1 receptor agonists activate the receptor’s two main signalling arms — cAMP production and β-arrestin recruitment — more or less together. Ecnoglutide (XW003)…
Metabolic & longevity
Adiponectin is one of the more interesting hormones in metabolic research: a fat-derived signal whose levels fall exactly when the body needs more of…
Occasional, considered notes on the compounds and the literature. No noise.
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