Plain-spoken notes on the compounds we supply — what the literature shows, how to read a COA, and the protocols that protect your data. Cited, never hyped.
In the news
TwoStep Therapeutics cleared an IND for TS-104, a peptide-drug conjugate delivering MMAE through an integrin-binding peptide, alongside a $62.5m Series A. What PDCs change…
Metabolic & longevity
Semaglutide started at 20 months extended median lifespan in female mice from 742 to 834 days and beat matched calorie restriction on memory, exploration…
Regulation
The FDA published five warning letters to research-peptide sellers on 1 September 2026. All five rest on website review alone, and the agency states…
In the news
Novo Nordisk reported that 40.4% of children aged 6 to 11 fell below the obesity threshold on semaglutide against 0% on placebo. What that…
Methods & QC
A September 2026 Nature Communications study reports that trifluoroacetate, the counterion on most synthetic peptides, binds PPAR-alpha and produces metabolic effects in mice, including…
In the news
A Phase 1 study of BPC-157 after arthroscopic rotator cuff repair was posted to ClinicalTrials.gov on 3 September 2026. It is not the first…
Methods & QC
GLP-1 demand pushed peptide synthesis to metric-ton scale. At the same moment the EU restricted DMF and added DMAc and NEP to Annex XVII.…
Regulation
FDA revised 17 product-specific guidances for generic peptides and withdrew its 2021 synthetic peptide guidance. The five areas it targeted explain why the same…
Methods & QC
In one month: computationally designed antimicrobial nanopores that work in mice, an engineered peptide nanopore that detects single α-synuclein species, and LLM-assisted design of…
In the news
On 28 August 2026 FDA approved Mimrylo (rusfertide) for polycythemia vera — the first hepcidin-mimetic peptide medicine. The mechanism is iron restriction, and it…
In the news
Avexitide is a GLP-1 receptor antagonist — the same target as semaglutide, the opposite direction. In August 2026 it cut severe hypoglycaemic events by…
Methods & QC
Human amylin forms amyloid fibrils in the pancreas, which is why it was undruggable. Three proline substitutions borrowed from rat amylin fixed it. And…
Occasional, considered notes on the compounds and the literature. No noise.
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