Research use only · EU-warehoused · COA on every batch · HPLC ≥99% · Shipment 2–5 days
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SLU-PP-332 Capsules

SLU-PP-332 Capsules

Lyophilised · ≥98% (HPLC) ·

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Custom quantity
1

Supplied lyophilised. Reconstitution typically uses bacteriostatic water.

Independently third-party tested · COA on every batch · 48h EU dispatch
[01]

Overview

SLU-PP-332 is a synthetic small-molecule ERR (estrogen-related receptor) pan-agonist — activating ERRα, ERRβ and ERRγ — developed as a tool compound to study mitochondrial biogenesis, oxidative metabolism and exercise-mimetic pathways in vitro and in vivo. CAS 303760-60-3; molecular formula C₁₈H₁₄N₂O₂; molecular weight 290.3 g/mol. Supplied in encapsulated form at ≥99% purity by HPLC. For laboratory research use only; not for human or veterinary use.

What if a molecule could mimic, at the level of gene expression, the metabolic signature of an endurance workout — without the treadmill? That is the question that has made SLU-PP-332 one of the most-discussed 'exercise mimetic' tool compounds in metabolic research. It is a synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ and ERRγ), a family of orphan nuclear receptors that act as master switches for the oxidative, mitochondria-rich metabolism muscle adopts during sustained activity.

Switching on the oxidative program. The ERR receptors sit at the centre of how skeletal muscle and other tissues govern mitochondrial energetics and fatty-acid utilisation (Fan et al., 2025; Yoh et al., 2023). By engaging all three ERR isoforms, SLU-PP-332 is studied as a chemical means of pushing cells toward this endurance-type metabolic state, and medicinal-chemistry work continues to dissect exactly how its structure drives ERR signalling (Okda et al., 2026).

What the research explores. Across cell-culture and animal systems, SLU-PP-332 has been investigated along several converging lines:

  • Oxidative metabolism & endurance models — studied as an ERR-agonist probe of mitochondrial energetics and aerobic-capacity endpoints (Fan et al., 2025; Billon et al., 2026).
  • Fatty-acid utilisation & metabolic-liver research — examined in ERRα-linked steatotic-liver and lipid-handling paradigms (Antwi et al., 2025; Gao et al., 2026).
  • Analytical & doping-control characterisation — profiled for its in-vitro metabolites as a pan-ERR agonist of interest to anti-doping science (Avliyakulov et al., 2026; Möller et al., 2026).

The activity described here is drawn from in-vitro and animal studies; it characterises biological behaviour in experimental models and does not establish efficacy or safety in humans. Full citations are listed under the Scientific References tab.

Physicochemical profile. CAS No. 303760-60-3 · Molecular formula C18H14N2O2 · Molecular weight 290.3 g/mol · Appearance: White to off-white powder · Solubility: Soluble in DMSO.

Specification & quality. Each bottle contains 60 HPMC (vegan) capsules, available in 500 mcg and 1 mg per capsule of SLU-PP-332 at ≥98% (HPLC). Encapsulated — no reconstitution required. Every batch is independently third-party tested, and a Certificate of Analysis (COA) is available. Store at room temperature, protect from moisture and light; shelf life 24 months from the manufacture date. EU warehoused.

This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.

Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.

[04]

Quality & COA

Certificate of Analysis
Lot-specific COA with every order

Certificate of Analysis — lot-specific COA ships with every order and is available on request.

Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.

HPLC purity
≥98% (HPLC)
Method
HPLC + MS
Endotoxin
Reported
[02]

Data Sheet

CAS number303760-60-3
Molecular formulaC18H14N2O2
Molecular weight290.3
Purity≥98% (HPLC)
Physical formWhite to off-white powder
Quantity60 capsules
SolubilitySoluble in DMSO
StorageStore at room temperature, protect from moisture and light
ReconstitutionEncapsulated — no reconstitution required.
Shelf life24 months from manufacture date
Dose per capsule500mcg / 1mg
Capsule materialHPMC (Vegan)
OriginEU · Slovakia
ClassificationResearch use only
[03]

Scientific References

01 Hansen M, Gliemann L, Hellsten Y Optimizing Female Health: The Crucial Role of Exercise Initiation before and during the Menopausal Transition. Exercise and sport sciences reviews. 2025;53(4):195-204. PMID: 40993047. doi:10.1249/JES.0000000000000371. PubMed 02 Yoh K, Ikeda K, Horie K, Inoue S Roles of Estrogen, Estrogen Receptors, and Estrogen-Related Receptors in Skeletal Muscle: Regulation of Mitochondrial Function. International journal of molecular sciences. 2023;24(3). PMID: 36768177. doi:10.3390/ijms24031853. PubMed 03 Gulwani D, Upadhyay P, Goel R, Sarangthem V, Debraj Singh T Unfolding of Imminent Bio-Signatures in the Prognosis of Thyroid Cancer; The Emergence of Estrogen Related Receptor Gamma (ERRγ) as a Hurricane. Asian Pacific journal of cancer prevention : APJCP. 2023;24(2):375-387. PMID: 36853284. doi:10.31557/APJCP.2023.24.2.375. PubMed 04 Ranhotra HS Estrogen-related receptor alpha in select host functions and cancer: new frontiers. Molecular and cellular biochemistry. 2022;477(5):1349-1359. PMID: 35138514. doi:10.1007/s11010-022-04380-w. PubMed 05 Gorski T, De Bock K Metabolic regulation of exercise-induced angiogenesis. Vascular biology (Bristol, England). 2019;1(1):H1-H8. PMID: 32923947. doi:10.1530/VB-19-0008. PubMed 06 May FE Novel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancer. Cancer management and research. 2014;6:225-52. PMID: 24904222. doi:10.2147/CMAR.S35024. PubMed 07 Billon C, Appourchaux K, Côté I, Burris TP An orally active estrogen receptor-related receptor agonist, SLU-PP-915, enhances aerobic exercise capacity. The Journal of pharmacology and experimental therapeutics. 2026;393(1):103787. PMID: 41421047. doi:10.1016/j.jpet.2025.103787. PubMed 08 Hu H, Yang Q, Hu J, Fan Y, Zhang Z, Yang K et al. ESRRA-ATG5-Mediated mitophagy enhances arginine metabolism to alleviate diabetic kidney disease. Autophagy. 2026;22(4):666-690. PMID: 41376268. doi:10.1080/15548627.2025.2601874. PubMed 09 Okda HE, Zhao P, Hayes M, Duvall C, Quillin E, Fang H et al. Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling. International journal of biological macromolecules. 2026;355:151450. PMID: 41850449. doi:10.1016/j.ijbiomac.2026.151450. PubMed 10 Avliyakulov NK, Sobolevsky T, Ahrens E Analysis and Identification of In Vitro Metabolites of Exercise Mimetic SLU-PP-332 ERRα/β/γ Agonist for Doping-Control Purposes. Drug testing and analysis. 2026;18(3):439-450. PMID: 41688415. doi:10.1002/dta.70035. PubMed 11 Gao J, Yang M, Duan R, Huang T, Li P, Gao L et al. Hepatocyte estrogen-related receptor α modulates a gluconeogenic-epigenetic crosstalk counteracting MASLD/MASH progression. Experimental & molecular medicine. 2026;58(5):1536-1555. PMID: 42104013. doi:10.1038/s12276-026-01707-1. PubMed 12 Möller T, Krug O, Thevis M In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential. Rapid communications in mass spectrometry : RCM. 2026;40(8):e70039. PMID: 41588687. doi:10.1002/rcm.70039. PubMed 13 Antwi MB, Lefere S, Clarisse D, Koorneef L, Heldens A, Onghena L et al. PPARα-ERRα crosstalk mitigates metabolic dysfunction-associated steatotic liver disease progression. Metabolism: clinical and experimental. 2025;164:156128. PMID: 39743041. doi:10.1016/j.metabol.2024.156128. PubMed 14 Fan W, Oh TG, Wang HJ, Crossley L, He M, Robbins H et al. Estrogen-related receptors regulate innate and adaptive muscle mitochondrial energetics through cooperative and distinct actions. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(20):e2426179122. PMID: 40354528. doi:10.1073/pnas.2426179122. PubMed 15 Nguyen TTH, Huang YX, Poliakova S, Citu C, Mann E, Sopariwala DH et al. Estrogen-Related Receptor Alpha Promotes Skeletal Muscle Regeneration and Mitigates Muscular Dystrophy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2025;39(19):e71094. PMID: 41065769. doi:10.1096/fj.202501764R. PubMed

References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.

[05]

FAQ

SLU-PP-332 is a synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ and ERRγ), orphan nuclear receptors that regulate mitochondrial energetics and oxidative metabolism (Fan et al., 2025). It is studied as an 'exercise mimetic' tool compound in skeletal-muscle and metabolic models, and is offered in two research tiers, 500 mcg and 1 mg per capsule. Condor Research supplies it strictly as a Research Use Only reference compound, never for human or veterinary use.

Both tiers contain the identical SLU-PP-332 reference compound at ≥98% HPLC purity; they differ only in the pre-weighed amount per capsule — 500 mcg or 1 mg. The two tiers let laboratories choose the per-unit quantity that best fits their experimental design and dilution scheme. Both are supplied strictly for laboratory research use only and not for human or veterinary use.

Both are ERR-agonist exercise-mimetic tool compounds, but they are distinct chemical entities studied in parallel; SLU-PP-915 is a related orally active ERR agonist examined for aerobic-capacity endpoints (Billon et al., 2026). SLU-PP-332 remains the most-cited reference pan-ERR agonist and is frequently the comparator in such work. Both are supplied only as research-use-only reference compounds.

They act on entirely different machinery. SLU-PP-332 is a nuclear-receptor agonist that switches on ERR-driven oxidative gene programs (Yoh et al., 2023), whereas 5-Amino-1MQ is an enzyme inhibitor targeting NNMT within NAD+/SAM metabolism. They address separate research questions — receptor signalling versus enzymatic regulation — and both are offered strictly for laboratory research use only.

SLU-PP-332 is a small-molecule ERR agonist acting through nuclear-receptor signalling, while MOTS-c is a mitochondrial-derived peptide studied as a secreted metabolic regulator. They belong to different chemical classes and probe different layers of mitochondrial biology (Fan et al., 2025). Both are supplied as research-use-only reference compounds for in vitro and animal studies.

Yes. Condor Research supplies SLU-PP-332 strictly as a Research Use Only reference compound to professionals and institutions, not as a medicine, supplement or product for human or veterinary use. Buyers are responsible for confirming import legality in their own country. Questions: info@condorresearch.com.

The capsule is a pre-weighed solid format that standardises the quantity of reference compound per unit, which simplifies bench handling and inventory for laboratory work. Each is an HPMC (vegan) capsule containing the powder — no reconstitution is required, and the format does not imply or permit any form of consumption. For laboratory research use only. Not for human or veterinary use.

Each bottle contains 60 HPMC (vegan) capsules. SLU-PP-332 is available in 500 mcg and 1 mg per capsule at ≥98% HPLC purity, and every batch is independently third-party tested. The per-capsule figure denotes only the pre-weighed quantity of reference compound for laboratory measurement — this product is for research use only and not for human or veterinary use.

SLU-PP-332 has CAS No. 303760-60-3, a molecular formula of C18H14N2O2 and a molecular weight of 290.3 g/mol. It presents as a white to off-white powder, soluble in DMSO. These specifications are provided for laboratory identification and research use only.

Yes. Every SLU-PP-332 batch — in both the 500 mcg and 1 mg tiers — is tested by an independent third-party laboratory by HPLC for identity and purity (≥98%), and each lot ships with a lot-specific Certificate of Analysis. To request the COA for your batch, contact info@condorresearch.com. The material is supplied for research use only.

[06]

Reviews

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4.7
81 verified reviews
5
78%
4
16%
3
4%
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Apr 2026
Reliable, well documented

Solubility and stability were as described. Knocked one star only because express shipping options are limited, but quality is not in question.

P. Andersson · Research institute · SE Verified purchase
Mar 2026
Reproducible across batches

Third order with Condor. Batch-to-batch variation is minimal, which matters for our longitudinal work. The mono-labelled vials are easy to track.

Dr. R. Costa · Academic lab · PT Verified purchase
Mar 2026
Exactly what research needs

No marketing fluff — just characterised material with paperwork. The data sheet and CAS matched our records precisely.

J. Meijer · Biotech R&D · NL Verified purchase
Feb 2026
High purity, clear labelling

Lyophilised cake was uniform and dissolved fully. Would appreciate a digital COA portal, but the PDF on request worked fine.

Dr. A. Bianchi · University · IT Verified purchase
Jan 2026
Trustworthy supplier

Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.

K. Wójcik · Research group · PL Verified purchase

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