Lyophilised · ≥98% (HPLC) ·
Supplied lyophilised. Reconstitution typically uses bacteriostatic water.
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates NAD⁺ availability and one-carbon metabolism in adipose tissue. CAS 685079-15-6 (quinolinium cation); molecular weight 159.21 g/mol. Supplied as oral capsules. For laboratory research use only; not for human or veterinary use.
Every cell quietly burns through NAD+, the molecular currency that powers metabolism, repair and energy production — and one enzyme, NNMT, sits at the drain valve that bleeds that currency away. 5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), and it has become a favoured chemical probe for researchers asking what happens when that drain is partially closed in cultured cells and animal tissues.
A chemical handle on the NAD+/SAM economy. NNMT consumes both nicotinamide (an NAD+ precursor) and the universal methyl donor S-adenosylmethionine (SAM), positioning it at the crossroads of two of the cell's most important metabolic budgets. Because elevated NNMT activity has been linked to disordered energy metabolism across tissue models, the enzyme has emerged as a much-discussed target for chemical inhibition (Gao et al., 2021; Puleo et al., 2026), and 5-Amino-1MQ is one of the most-cited tool compounds used to interrogate it.
What the research explores. Across cell-culture and animal systems, 5-Amino-1MQ has been investigated along several converging lines:
The activity described here is drawn from in-vitro and animal studies; it characterises biological behaviour in experimental models and does not establish efficacy or safety in humans. Full citations are listed under the Scientific References tab.
Physicochemical profile. CAS No. 685079-15-6 · Molecular formula C10H11N2+ (iodide salt) · Molecular weight 159.21 g/mol · Appearance: Off-white to pale-yellow powder · Solubility: Soluble in water and DMSO.
Specification & quality. Each bottle contains 60 HPMC (vegan) capsules, each providing 50mg of 5-Amino-1MQ at ≥98% (HPLC). Encapsulated — no reconstitution required. Every batch is independently third-party tested, and a Certificate of Analysis (COA) is available. Store at room temperature, protect from light and moisture; shelf life 24 months from the manufacture date. EU warehoused.
This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.
Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.
Certificate of Analysis — lot-specific COA ships with every order and is available on request.
Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.
References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), which sits at the junction of NAD+ and methyl-donor (SAM) metabolism. It is widely used as a chemical-probe tool compound to study NNMT inhibition in cell-culture and animal models (Gao et al., 2021). Condor Research supplies it strictly as a Research Use Only reference compound for in vitro and animal studies, never for human or veterinary use.
The two work from opposite ends of the same pathway. NMN (nicotinamide mononucleotide) is a direct NAD+ precursor studied as a substrate that feeds the NAD+ pool, whereas 5-Amino-1MQ is an enzyme inhibitor that blocks NNMT, the enzyme that diverts nicotinamide and methyl groups away from NAD+ salvage (Gao et al., 2021). They answer different research questions — substrate supplementation versus enzymatic regulation — and both are supplied only as research-use-only reference compounds.
NAD+ is the coenzyme itself, central to energy metabolism, while 5-Amino-1MQ is a small molecule studied for its ability to inhibit NNMT, an enzyme that influences how nicotinamide and methyl-donor pools are partitioned (Nejabati et al., 2022). Researchers use NAD+ as a metabolic readout and 5-Amino-1MQ as an upstream chemical lever; the two are complementary tools in metabolism studies. Both are offered strictly for laboratory research use only.
NNMT is being pursued through several chemical strategies, including bisubstrate and structure-based inhibitor designs explored in the literature (Yoshida et al., 2026). 5-Amino-1MQ is valued as an accessible, well-characterised small-molecule probe for first-pass NNMT-inhibition experiments rather than a clinical agent. It is supplied only as a Research Use Only reference compound for in vitro and animal work.
Yes. Condor Research supplies 5-Amino-1MQ strictly as a Research Use Only reference compound to professionals and institutions, not as a medicine, supplement or product for human or veterinary use. Buyers are responsible for confirming import legality in their own country. Questions: info@condorresearch.com.
The capsule is simply a pre-weighed solid format that standardises the amount of reference compound per unit, making bench handling and inventory cleaner for laboratory work. Each is an HPMC (vegan) capsule containing the powder — no reconstitution is required, and the format does not imply or permit any form of consumption. For laboratory research use only. Not for human or veterinary use.
No. The 5-Amino-1MQ is already encapsulated as a solid powder, so no reconstitution is required for handling. Researchers preparing in-vitro stocks typically dissolve the compound in water or DMSO per their own protocol. This is a laboratory reference material supplied for research use only, not for ingestion.
Each bottle contains 60 HPMC (vegan) capsules, with 50mg of 5-Amino-1MQ per capsule at ≥98% HPLC purity. Every batch is independently third-party tested. The term 'dose' here refers only to the pre-weighed quantity of reference compound per capsule for laboratory measurement — this product is for research use only and not for human or veterinary use.
5-Amino-1MQ has CAS No. 685079-15-6, a molecular formula of C10H11N2+ (iodide salt) and a molecular weight of 159.21 g/mol. It presents as an off-white to pale-yellow powder, soluble in water and DMSO. These specifications are provided for laboratory identification and research use only.
Yes. Every 5-Amino-1MQ batch is tested by an independent third-party laboratory by HPLC for identity and purity (≥98%), and each lot ships with a lot-specific Certificate of Analysis. To request the COA for your batch, contact info@condorresearch.com. The material is supplied for research use only.
Store at room temperature, protected from light and moisture, with a shelf life of 24 months from the manufacture date. Keep capsules in their sealed container until needed for research preparation. This is a laboratory reference compound for research use only — not for human or veterinary use, ingestion, or diagnostic application.
Solubility and stability were as described. Knocked one star only because express shipping options are limited, but quality is not in question.
Third order with Condor. Batch-to-batch variation is minimal, which matters for our longitudinal work. The mono-labelled vials are easy to track.
No marketing fluff — just characterised material with paperwork. The data sheet and CAS matched our records precisely.
Lyophilised cake was uniform and dissolved fully. Would appreciate a digital COA portal, but the PDF on request worked fine.
Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.
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