Lyophilised · ≥99% (HPLC) ·
Supplied lyophilised. Reconstitution typically uses bacteriostatic water.
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) and one of the most-cited tool compounds for probing NAD+/SAM-pool biology in cell-culture and animal models. CAS 685079-15-6; molecular weight 159.21 g/mol; soluble in water and DMSO. Not a peptide. For laboratory research use only; not for human or veterinary use.
Built to silence an enzyme that sits at a crossroads of cellular methylation and NAD⁺ metabolism, 5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) and a focused research tool in metabolic and cellular biology. This small molecule — not a peptide — is a membrane-permeable quinolinium compound used to interrogate what happens when NNMT activity is pharmacologically suppressed.
A targeted brake on a metabolic enzyme. NNMT catalyses the methylation of nicotinamide, consuming methyl groups and influencing both the cellular methylation landscape and NAD⁺ salvage pathways. Elevated NNMT activity has been observed in a range of metabolic and proliferative contexts, which has made selective inhibition an attractive experimental strategy. 5-Amino-1MQ was characterised as a small-molecule NNMT inhibitor that enters cells and reduces enzyme activity, giving researchers a direct way to probe NNMT-dependent metabolism.
What the research explores. Studies in cellular and animal models have examined NNMT inhibition along a few principal lines:
These observations arise from in vitro and animal studies conducted in controlled research settings; they characterise the compound's pharmacology and do not constitute evidence of benefit for any non-investigational purpose. Full citations are listed under the Scientific References tab.
Physicochemical profile. CAS 685079-15-6 · Molecular formula C₁₀H₁₁N₂⁺ · Molecular weight 159.21 · Appearance: off-white to white powder · Solubility: soluble in water.
Specification & quality. Each individually sealed vial contains 10 mg of 5-Amino-1MQ as an off-white to white powder, verified at ≥99% purity by HPLC. Every batch is third-party tested, and a Certificate of Analysis (COA) is available. Store at −20 °C, protected from light and moisture.
This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.
Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.
Certificate of Analysis — lot-specific COA ships with every order and is available on request.
Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.
References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme at the crossroads of cellular methylation and NAD⁺ metabolism, used as a focused research tool. It is a small molecule, not a peptide. It is supplied strictly for laboratory research use only (in vitro), not for human or veterinary use, administration or consumption.
5-Amino-1MQ is a small molecule (molecular formula C₁₀H₁₁N₂⁺, MW ~159.21, CAS 685079-15-6), not a peptide, and has no amino-acid sequence. Although it is listed under the vials catalog, it is chemically a small-molecule NNMT inhibitor supplied strictly for laboratory research use only (in vitro), not for human or veterinary use, administration or consumption.
Both are water-soluble small-molecule metabolic research tools, but they act on different targets: 5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), while AICAR activates AMP-activated protein kinase (AMPK). One is an enzyme inhibitor, the other a kinase activator. Both are supplied strictly for laboratory research use only (in vitro) and are not for human or veterinary use, administration or consumption.
5-Amino-1MQ is a small molecule that inhibits NNMT, an enzyme linked to NAD⁺ metabolism, whereas NAD+ is the coenzyme nicotinamide adenine dinucleotide itself. One is an enzyme-targeting tool compound; the other is the cofactor central to energy metabolism. Both are supplied strictly for laboratory research use only (in vitro), not for human or veterinary use, administration or consumption.
5-Amino-1MQ inhibits the enzyme NNMT and is water-soluble, while SLU-PP-332 is an agonist of the estrogen-related receptors (ERRs) and is DMSO-soluble. They engage different metabolic mechanisms and require different solvents for laboratory preparation. Both are small molecules supplied strictly for laboratory research use only (in vitro), not for human or veterinary use, administration or consumption.
These three small molecules act on distinct targets: 5-Amino-1MQ inhibits NNMT, AICAR activates AMPK, and SLU-PP-332 is an ERR agonist. The right tool depends on the metabolic pathway under study. AICAR and 5-Amino-1MQ are water-soluble; SLU-PP-332 is DMSO-soluble. All three are supplied strictly for laboratory research use only (in vitro), not for human or veterinary use.
Yes. The reference count simply reflects that this is a newer, more specialised research tool, not lower quality. Each batch is still tested by an independent third-party laboratory with purity verified at ≥99% by HPLC, and a per-lot Certificate of Analysis is issued. To request the COA for a specific batch, contact info@condorresearch.com. Supplied for laboratory research use only.
Each lot is tested by an independent third-party laboratory with purity verified at ≥99% by HPLC and a Certificate of Analysis issued per batch. For small-molecule structural confirmation such as NMR/HRMS, or reported mechanistic data, contact info@condorresearch.com to confirm what is available for a given batch. 5-Amino-1MQ is supplied strictly for laboratory research use only (in vitro).
5-Amino-1MQ is listed as soluble in water, so an aqueous stock is prepared for analytical laboratory use; the vial contains 10 mg. Store the unopened vial at -20°C, protected from light (24-month shelf life). Any preparation data is for in-vitro laboratory use only, never for human or animal use. For batch-specific handling details, contact info@condorresearch.com.
Solubility and stability were as described. Knocked one star only because express shipping options are limited, but quality is not in question.
Third order with Condor. Batch-to-batch variation is minimal, which matters for our longitudinal work. The mono-labelled vials are easy to track.
No marketing fluff — just characterised material with paperwork. The data sheet and CAS matched our records precisely.
Lyophilised cake was uniform and dissolved fully. Would appreciate a digital COA portal, but the PDF on request worked fine.
Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.
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