AOD-9604

AOD-9604 (Anti-Obesity Drug 9604) is a synthetic 16-amino-acid peptide fragment corresponding to the C-terminal region (Tyr-hGH177–191) of human growth hormone, modified with a tyrosine residue at the N-terminus to enhance stability; CAS 221231-10-3; molecular formula C78H123N23O23S2; molecular weight 1815.1 g/mol; studied in adipogenesis, lipolysis regulation, and metabolic research models. Supplied lyophilised at HPLC ≥99% purity. For laboratory research use only; not for human or veterinary use.

Derived from the very tail of the human growth-hormone molecule, AOD-9604 is a synthetic peptide fragment corresponding to the C-terminal lipolytic domain of hGH (residues 177-191) with an added tyrosine and a stabilising disulfide bridge. It was designed around a simple hypothesis: that the fat-metabolising activity of growth hormone could be isolated from the rest of its signalling, and it has since become a reference compound in metabolic-peptide research.

One function, distilled from a larger hormone. Full-length growth hormone exerts many effects, of which lipid mobilisation is only one. Investigators mapped this lipolytic activity to the hormone's C-terminal region and synthesised the corresponding fragment to probe it in isolation (Ng et al., 2000). Because the peptide reproduces fat-metabolism signalling without acting through the classic IGF-1-raising pathway, it offered a cleaner experimental window into adipocyte regulation.

What the research explores. The fragment has been examined across metabolic and musculoskeletal models:

• Lipid metabolism — characterised for its effects on lipolysis and lipogenesis in fat tissue and animal models (Heffernan et al., 2001; Ng et al., 2000).
• Metabolic-disease context — reviewed as an investigational metabolic agent (Wilding et al., 2004).
• Cartilage & joint models — studied via intra-articular injection, with and without hyaluronic acid, in a rabbit osteoarthritis model (Kwon et al., 2015).
• In vitro metabolism & detection — its metabolic fate and analytical detection have been characterised (Cox et al., 2015).

All such findings stem from in vitro and animal research; no human-use conclusions are implied. Full citations are listed under the Scientific References tab.

Physicochemical profile. CAS 221231-10-3 · Molecular formula C₇₈H₁₂₃N₂₃O₂₃S₂ · Molecular weight 1815.1 · Sequence Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (Cys⁷–Cys¹⁴ disulfide) · Appearance: white lyophilized powder · Solubility: soluble in water.

Specification & quality. Each individually sealed vial contains 5 mg of AOD-9604 as a white lyophilized powder of ≥99% purity by HPLC. Every batch is third-party tested, with a Certificate of Analysis (COA) available. Store at −20 °C, protected from light and moisture. Shelf life: 24 months from the manufacture date.

This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.