AOD-9604 Capsules

AOD-9604 is a synthetic 16-amino-acid peptide corresponding to Tyr-hGH(177–191) — the tyrosylated C-terminal fragment of human growth hormone — stabilised by an intramolecular disulfide bond. CAS 221231-10-3; molecular formula C78H123N23O23S2; molecular weight approximately 1815.1 g/mol; supplied in encapsulated form at ≥99% purity by HPLC. Investigated in preclinical models for its role in lipid metabolism, adipogenesis inhibition, and fat oxidation. For laboratory research use only; not for human or veterinary use.

Take the very tail of human growth hormone, trim it to sixteen residues, and bolt a tyrosine onto the front — and you have a peptide engineered to keep one of hormone's jobs while shedding the rest. AOD-9604 is a modified analogue of the C-terminal fragment of human growth hormone (residues 177–191), studied specifically because it appears to engage lipid-metabolism pathways without the IGF-1-driven, growth-promoting signalling of the full hormone.

A growth-hormone fragment, by design. AOD-9604 was developed from the hGH 177–191 region as one of a wave of candidate anti-obesity agents that aimed to isolate growth hormone's metabolic, fat-mobilising activity from its anabolic effects, and it features in reviews charting that class of compounds in metabolic research (Khan et al., 2012; Zieba, 2007).

Because of its hGH-fragment origin, the peptide has also become a reference analyte in anti-doping science, where analytical groups have characterised its detection and in-vitro metabolism and confirmed that it does not interfere with the WADA hGH isoform immunoassay (Cox et al., 2015; Orlovius et al., 2013).

What the research explores. Across cell-culture and animal systems, AOD-9604 has been investigated along several converging lines:

• Lipid-metabolism research — studied as a fragment that engages fat-mobilising pathways while being positioned apart from IGF-1-mediated growth signalling, within the metabolic-compound literature (Khan et al., 2012; Bayés et al., 2005).
• Joint & cartilage models — examined by intra-articular injection, with or without hyaluronic acid, in a rabbit osteoarthritis model (Kwon & Park, 2015).
• Analytical & metabolic characterisation — detection and in-vitro metabolism profiled by mass-spectrometry-based methods (Cox et al., 2015; Thomas et al., 2016).

The activity described here is drawn from in-vitro and animal studies; it characterises biological behaviour in experimental models and does not establish efficacy or safety in humans. Full citations are listed under the Scientific References tab.

Physicochemical profile. CAS No. 221231-10-3 · Molecular formula C78H123N23O23S2 · Molecular weight 1815.08 g/mol · Sequence Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (hGH 177-191 analogue, disulfide Cys7-Cys14) · Appearance: White lyophilized powder · Solubility: Soluble in water.

Specification & quality. Each bottle contains 60 HPMC (vegan) capsules, each providing 300mcg of AOD-9604 at ≥99% (HPLC). Encapsulated — no reconstitution required. Every batch is independently third-party tested, and a Certificate of Analysis (COA) is available. Store at -20°C, protect from light and moisture; shelf life 24 months from the manufacture date. EU warehoused.

This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.