{ "schema_version": "1.0", "title": "SLU-PP-332 and SLU-PP-915: selected primary evidence", "language": "en", "verified_at": "2026-09-15", "scope": "Curated starting set of five primary studies on two distinct ERR research compounds. This is not a systematic or exhaustive review. Summaries describe published research, not experiments performed by Condor Research.", "use_context": "Research Use Only. No human-use instructions or product efficacy claims.", "entities": [ { "id": "slu-pp-332", "name": "SLU-PP-332", "aliases": [], "identity_note": "Distinct small-molecule pan-ERR research agonist; not SLU-PP-915.", "source_pmids": [ "36988910", "37961903" ] }, { "id": "slu-pp-915", "name": "SLU-PP-915", "aliases": [ { "name": "10s", "scope": "Compound label in Hampton et al. 2023 only", "source_pmid": "37421886" } ], "identity_note": "Chemically distinct from SLU-PP-332. The discovery abstract explicitly identifies SLU-PP-915 as compound 10s.", "source_pmids": [ "37421886", "37961903", "41421047" ] } ], "studies": [ { "id": "pmid-36988910", "title": "Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity", "year": 2023, "doi": "10.1021/acschembio.2c00720", "pmid": "36988910", "url": "https://pubmed.ncbi.nlm.nih.gov/36988910/", "doi_url": "https://doi.org/10.1021/acschembio.2c00720", "entity_ids": [ "slu-pp-332" ], "model": "Skeletal muscle cell line and mouse exercise experiments.", "finding": "SLU-PP-332 activated all three ERR isoforms in the reported assays. The researchers observed increased cellular respiration, oxidative muscle fibers and exercise endurance; the mouse endurance response depended on ERRα.", "limitation": "Cellular and mouse endpoints do not establish human performance effects, clinical efficacy or safety. ERRα dependence in this experiment does not establish identical dependence in every tissue.", "provenance": { "verified_at": "2026-09-15", "source_type": "primary_research", "verification_scope": "Published abstract and bibliographic record; detailed full-text extraction was not available.", "source_locator": "Abstract", "metadata_url": "https://europepmc.org/article/MED/36988910" } }, { "id": "pmid-37421886", "title": "Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915", "year": 2023, "doi": "10.1016/j.ejmech.2023.115582", "pmid": "37421886", "url": "https://pubmed.ncbi.nlm.nih.gov/37421886/", "doi_url": "https://doi.org/10.1016/j.ejmech.2023.115582", "entity_ids": [ "slu-pp-915" ], "model": "Cell-based receptor assays, protein-binding experiments, microsomal assays and in vitro/in vivo gene-expression experiments.", "finding": "The authors identified SLU-PP-915 as compound 10s in a chemically distinct series of pan-ERR agonists. The reported gene-expression experiments showed induction of ERR target genes.", "limitation": "This discovery study supports chemical-probe characterization. It does not establish clinical outcomes or a universal potency ranking against SLU-PP-332; assay conditions matter.", "provenance": { "verified_at": "2026-09-15", "source_type": "primary_research", "verification_scope": "Published abstract and bibliographic record; 10s identity is stated explicitly in the abstract. Model details are deliberately limited to the accessible abstract.", "source_locator": "Abstract", "metadata_url": "https://europepmc.org/article/MED/37421886" } }, { "id": "pmid-37739806", "title": "A Synthetic ERR Agonist Alleviates Metabolic Syndrome", "year": 2024, "doi": "10.1124/jpet.123.001733", "pmid": "37739806", "url": "https://pubmed.ncbi.nlm.nih.gov/37739806/", "doi_url": "https://doi.org/10.1124/jpet.123.001733", "entity_ids": [ "slu-pp-332" ], "model": "Diet-induced obese and ob/ob mouse models.", "finding": "The study reported increased energy expenditure and fatty acid oxidation, reduced fat-mass accumulation and changes in insulin sensitivity in the investigated mouse models.", "limitation": "These are model-specific preclinical findings, not evidence of weight-management efficacy or safety in humans. They cannot be reassigned to SLU-PP-915.", "provenance": { "verified_at": "2026-09-15", "source_type": "primary_research", "verification_scope": "Published abstract, publisher record and bibliographic record; no independent effect-size reanalysis.", "source_locator": "Abstract", "metadata_url": "https://europepmc.org/article/MED/37739806" } }, { "id": "pmid-37961903", "title": "Novel pan-ERR agonists ameliorate heart failure through enhancing cardiac fatty acid metabolism and mitochondrial function", "year": 2024, "doi": "10.1161/CIRCULATIONAHA.123.066542", "pmid": "37961903", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10842599/", "doi_url": "https://doi.org/10.1161/CIRCULATIONAHA.123.066542", "entity_ids": [ "slu-pp-332", "slu-pp-915" ], "model": "Mouse pressure-overload model, neonatal rat ventricular myocytes and genetic dependency experiments.", "finding": "Both structurally distinct compounds changed cardiac metabolic programs and functional endpoints in the pressure-overload model. Genetic experiments identified ERRγ as a major mediator of the observed response.", "limitation": "Results in this experimental disease model do not establish a cardiac treatment in humans. Findings on both compounds do not make their chemistry, exposure or performance interchangeable.", "provenance": { "verified_at": "2026-09-15", "source_type": "primary_research", "verification_scope": "PMC author manuscript: abstract, methods and introduction inspected; no independent effect-size reanalysis.", "source_locator": "Abstract; Methods: Animals and Neonatal rat ventricular myocytes", "metadata_url": "https://europepmc.org/article/MED/37961903" } }, { "id": "pmid-41421047", "title": "An orally active estrogen receptor-related receptor agonist, SLU-PP-915, enhances aerobic exercise capacity", "year": 2026, "doi": "10.1016/j.jpet.2025.103787", "pmid": "41421047", "url": "https://pubmed.ncbi.nlm.nih.gov/41421047/", "doi_url": "https://doi.org/10.1016/j.jpet.2025.103787", "entity_ids": [ "slu-pp-915", "slu-pp-332" ], "model": "Preclinical mouse exercise-capacity experiments with exposure-adjusted comparison.", "finding": "SLU-PP-915 was reported to retain exercise-capacity activity after oral administration in the animal experiments. The authors compared it with SLU-PP-332 and reported similar activity under the tested, exposure-adjusted conditions.", "limitation": "This comparison does not establish human oral bioavailability, safety, clinical efficacy or universal superiority. Exposure-adjusted experimental comparisons are not instructions for use.", "provenance": { "verified_at": "2026-09-15", "source_type": "primary_research", "verification_scope": "Published abstract and bibliographic record; publisher full text was inaccessible during this check.", "source_locator": "Abstract", "metadata_url": "https://europepmc.org/article/MED/41421047" }, "first_online_date": "2025-12-01" } ], "comparison_notes": [ "Shared ERR-family activity does not imply chemical identity.", "The selected studies contain cellular and animal evidence; they do not establish human efficacy or safety. This statement describes this selected set, not an exhaustive search for human studies.", "Mouse exercise, metabolic and pressure-overload endpoints answer different research questions and should not be pooled into a single efficacy score.", "Publication year uses the journal issue year. The 2026 exercise-capacity article was first published online on 2025-12-01.", "No potency league table, CAS number, chemical formula, dosing protocol or claim about product batches is inferred from this dataset." ] }