Plain-spoken notes on the compounds we supply — what the literature shows, how to read a COA, and the protocols that protect your data. Cited, never hyped.
In the news
Which peptides Andrew Huberman has said he personally uses — pinealon, BPC-157, sermorelin — and what the primary literature actually shows about each.
In the news
Bryan Johnson has trialed CJC-1295, HGH, tirzepatide, cerebrolysin, epithalon, follistatin and BPC-157. A sourced look at what he measured, kept, and dropped.
Metabolic & longevity
A 2026 Copenhagen study reports MOTS-c improved intrinsic muscle mitochondrial quality in mice via PGC-1α and AMPK — without more mitochondria. RUO analysis.
Metabolic & longevity
Mitochondrial-derived peptides (MDPs) like humanin and MOTS-c are encoded inside mtDNA and act like hormones. What the cell, animal and human data actually show.
Metabolic & longevity
Exendin-4, the founding molecule of the GLP-1 drug class, was isolated from Gila monster venom by John Eng in 1992. The science-history behind the…
Methods & QC
How Limulus amebocyte lysate (LAL) from horseshoe crab blood became the endotoxin test behind every injectable's COA — plus the recombinant Factor C alternative.
Metabolic & longevity
A deflationary scorecard of popular longevity compounds ranked by real human RCT evidence: rapamycin, metformin, NAD precursors, spermidine, urolithin A and more.
Hormonal
A ranking of GH secretagogues — tesamorelin, MK-677, GHRP-2, sermorelin, CJC-1295, ipamorelin — by the quantity and quality of human and regulatory evidence, not…
Metabolic & longevity
An evidence-anchored ranking of senolytics — Dasatinib+Quercetin, fisetin, navitoclax, FOXO4-DRI — showing what human and mouse data actually support, and where the field has…
In the news
Joe Rogan says he uses BPC-157 and TB-500 to heal injuries. We fact-check the claims against the actual literature — what holds up, what…
In the news
A source-checked look at where Peter Attia actually stands on NMN, rapamycin, metformin, GLP-1 drugs and BPC-157 — and where popular hype runs past…
In the news
A source-checked look at Gary Brecka's claims on methylene blue, BPC-157, NAD+ and hydrogen — what the literature actually shows, and where certainty outruns…
Occasional, considered notes on the compounds and the literature. No noise.
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