Plain-spoken notes on the compounds we supply — what the literature shows, how to read a COA, and the protocols that protect your data. Cited, never hyped.
Comparisons
Two reference secretagogues, two receptors. A research-use comparison of their chemistry, mechanisms, and the honest state of the published evidence.
Comparisons
Two copper tripeptides differing by a single N-terminal residue — and by decades of evidence. A sober, research-use-only reading of what the literature on…
Comparisons
Two short-peptide bioregulators from the same St. Petersburg lineage, studied in different models. Telomere biology meets neuronal oxidative stress, all of it preclinical.
Comparisons
Two peptides forever paired in regenerative literature, yet chemically and mechanistically unrelated. What the preclinical record actually says, and why the choice is a…
Comparisons
Two compounds shelved side by side in metabolic catalogues turn out to share almost nothing at the molecular level — one switches an enzyme…
Nootropics
A CNTF-derived fragment rebuilt to cross the blood-brain barrier and switch on BDNF. The rodent data are genuinely striking. The translational record of everything…
Immune
Humans carry a single cathelicidin. It kills microbes, calls in immune cells and helps wounds close — and, in the wrong context, teaches the…
Metabolic & longevity
A small molecule made untrained mice run dramatically further. Two decades and several large human trials later, acadesine's record is a study in how…
Immune
Cibinetide was engineered to keep erythropoietin's tissue-protective signalling while abandoning its blood-building job. The molecular logic is elegant; the human evidence, gathered mostly in…
Metabolic & longevity
A naturally occurring polyamine that induces autophagy from yeast to mice, backed by striking mortality epidemiology — and undercut by randomised human trials that…
Skin & matrix
Afamelanotide (Scenesse) is a genuine EMA- and FDA-approved medicine for a rare photodermatosis. That regulatory pedigree is real, narrow, and routinely misrepresented by the…
Hormonal
The DAC modification is an elegant piece of chemistry that stretches a peptide's half-life from minutes to a week. The human evidence behind it…
Occasional, considered notes on the compounds and the literature. No noise.
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