In nootropic forums and vendor listings, “Adamax” is described as a modified or stabilised version of Semax, the Russian ACTH(4-10) peptide analogue that has accumulated decades of experimental research. The framing implies inheritance: a better Semax, still carrying Semax’s evidence behind it. A literature search does not support that implication. This piece lays out what…
Adalank appears on vendor listings as a “stabilised” or “second-generation” version of Selank, usually alongside the same bullet points that circulate about Selank itself. The claim is specific enough to be testable: a modified peptide, more resistant to breakdown, otherwise equivalent. So we tested it the way we test any compound before it goes near…
Most nootropic peptide marketing rests on a premise it never states: that the molecule reaches the brain. For peptides, that premise is the hardest part of the entire pharmacological argument to establish. A compound can be stable in plasma, bind its target at nanomolar affinity and behave beautifully in cultured neurons while still failing at…
Noopept (omberacetam, GVS-111): a proline-containing dipeptide designed as a piracetam analogue. Its chemistry, the proposed prodrug metabolite, and an honest read of the single-lab evidence.
Bromantane (Ladasten) is a Russian actoprotector that raises dopamine synthesis enzymes rather than blocking reuptake. What the rodent and clinical literature actually shows.
A mechanism-level research guide to Semax, the ACTH(4-10)-Pro-Gly-Pro heptapeptide: BDNF/NGF transcription, the dopaminergic system, and an honest read of animal-heavy and limited clinical evidence. Research use only.
A mechanism-level research guide to Selank, the tuftsin analogue Thr-Lys-Pro-Arg-Pro-Gly-Pro: enkephalinase inhibition, GABAergic and serotonergic signalling, gene-expression effects, and an honest read of animal-heavy evidence. Research use only.
A CNTF-derived fragment rebuilt to cross the blood-brain barrier and switch on BDNF. The rodent data are genuinely striking. The translational record of everything that came before it is not.
A porcine brain-derived peptide mixture prescribed across Eastern Europe and Asia for stroke and dementia — yet independent reviews are tepid, and you cannot fully say what is in the vial.
Dihexa is a metabolically stabilised peptidomimetic, derived from angiotensin IV, designed to drive the formation of new synapses through the HGF/c-Met growth system. Here is what the preclinical record actually shows — and the growth-pathway caveat that comes with it.
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