A mechanism-level research guide to Semax, the ACTH(4-10)-Pro-Gly-Pro heptapeptide: BDNF/NGF transcription, the dopaminergic system, and an honest read of animal-heavy and limited clinical evidence. Research use only.
A mechanism-level research guide to Selank, the tuftsin analogue Thr-Lys-Pro-Arg-Pro-Gly-Pro: enkephalinase inhibition, GABAergic and serotonergic signalling, gene-expression effects, and an honest read of animal-heavy evidence. Research use only.
A CNTF-derived fragment rebuilt to cross the blood-brain barrier and switch on BDNF. The rodent data are genuinely striking. The translational record of everything that came before it is not.
A porcine brain-derived peptide mixture prescribed across Eastern Europe and Asia for stroke and dementia — yet independent reviews are tepid, and you cannot fully say what is in the vial.
A small beta-carboline alkaloid that, in animal models, appears to stimulate, protect and even regenerate dopaminergic neurons — from a chemical family that also contains neurotoxins. Here is what the preclinical record actually shows.
Dihexa is a metabolically stabilised peptidomimetic, derived from angiotensin IV, designed to drive the formation of new synapses through the HGF/c-Met growth system. Here is what the preclinical record actually shows — and the growth-pathway caveat that comes with it.
J-147 is an experimental neuroprotective compound engineered at the Salk Institute from curcumin, the turmeric molecule the body destroys too fast to be a drug. Chemists rebuilt it for stability and ageing brains, and it turned out to act on an unexpected target inside the mitochondrion.
A blue dye older than aspirin helped found the pharmaceutical industry and still treats a rare blood disorder. At low concentrations it is now studied as a mitochondrial “electron cycler” for the brain — with a sharply two-sided dose-response.
A plant alkaloid, a fragment-derived peptidomimetic, a curcumin descendant, a 150-year-old dye and a vitamin-B3 relative. The cognitive-enhancement conversation is not only about peptides — and the small molecules are far stranger.
Semax is a synthetic heptapeptide derived from a fragment of the stress hormone ACTH, developed in Russia and studied as a nootropic and neuroprotective compound. Here, strictly a research-use-only material.
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