Dihexa is a metabolically stabilised peptidomimetic, derived from angiotensin IV, designed to drive the formation of new synapses through the HGF/c-Met growth system. Here is what the preclinical record actually shows — and the growth-pathway caveat that comes with it.
J-147 is an experimental neuroprotective compound engineered at the Salk Institute from curcumin, the turmeric molecule the body destroys too fast to be a drug. Chemists rebuilt it for stability and ageing brains, and it turned out to act on an unexpected target inside the mitochondrion.
A blue dye older than aspirin helped found the pharmaceutical industry and still treats a rare blood disorder. At low concentrations it is now studied as a mitochondrial “electron cycler” for the brain — with a sharply two-sided dose-response.
A plant alkaloid, a fragment-derived peptidomimetic, a curcumin descendant, a 150-year-old dye and a vitamin-B3 relative. The cognitive-enhancement conversation is not only about peptides — and the small molecules are far stranger.
Semax is a synthetic heptapeptide derived from a fragment of the stress hormone ACTH, developed in Russia and studied as a nootropic and neuroprotective compound. Here, strictly a research-use-only material.
Selank is a synthetic heptapeptide derived from the natural immune molecule tuftsin, developed in Russia and studied in animal models as an anxiolytic and nootropic peptide. Registered in Russia, it is not approved in the EU or US, and is supplied strictly for research use only.
Most nootropics people argue about online are small molecules. A quieter family is built from amino acids. A research-use-only field guide to the peptides studied for the brain — and to how thin the human evidence really is.
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