Research use only · EU-warehoused · COA on every batch · HPLC ≥99% · Shipment 2–5 days
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Pinealon

Pinealon

Lyophilised · ≥99% (HPLC) ·

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Supplied lyophilised. Reconstitution typically uses bacteriostatic water.

Independently third-party tested · COA on every batch · 48h EU dispatch
[01]

Overview

Pinealon is a synthetic tripeptide (Glu-Asp-Arg; EDR) derived from the pineal gland, studied for neuroprotective and neurogenic activity in preclinical models of neurodegeneration, oxidative stress, and cognitive decline. Molecular formula C15H26N6O8; molecular weight 418.40 g/mol; supplied as a 10 mg lyophilized vial at HPLC ≥99% purity. For laboratory research use only; not for human or veterinary use.

Some of the shortest peptides in biology may carry instructions that reach all the way to the genome. Pinealon is a synthetic tripeptide, Glu-Asp-Arg (the "EDR" peptide), developed within the field of short peptide bioregulators. Composed of just three amino acids, it is studied as a model for how minimal peptide sequences may influence neuronal viability, oxidative balance, and gene expression in cell and animal systems.

A three-letter word in the peptide-bioregulator alphabet. Research on short peptides proposes that sequences such as EDR are small enough to enter cells and even interact with DNA, potentially modulating the expression of specific genes — an epigenetic-style hypothesis that distinguishes this peptide class from receptor-only signaling molecules (Khavinson et al., 2020). Pinealon is frequently examined alongside other tripeptide bioregulators as a tool for probing these proposed mechanisms.

What the research explores. The literature centers on neuronal and protective endpoints:

  • Cell viability and oxidative stress — Pinealon has been reported to increase cell viability by suppressing free radical levels and supporting proliferation in cultured cells (Khavinson et al., 2011).
  • Gene-expression regulation — work proposes mechanisms by which the EDR peptide may influence gene expression and protein synthesis (Khavinson et al., 2020).
  • Developmental neuroprotection — studies report protection of rat offspring in a model of prenatal hyperhomocysteinemia (Arutjunyan et al., 2012).
  • Aging and neurodegeneration models — short tripeptide bioregulators have been examined in an Alzheimer's disease mouse model (Khavinson et al., 2021) and for protecting induced neurons from age-related changes (Kraskovskaya et al., 2024).

These findings come from in vitro and animal research describing biological activity; they do not establish safety or efficacy in humans. Full citations are listed under the Scientific References tab.

Physicochemical profile. CAS 175175-23-2 · Molecular formula C₁₅H₂₆N₆O₈ · Molecular weight 418.40 g/mol · Sequence Glu-Asp-Arg · Appearance: white lyophilized powder · Soluble in water.

Specification & quality. Each individually sealed vial contains 10 mg of Pinealon as a white lyophilized powder at ≥99% purity by HPLC. Every batch is third-party tested, with a Certificate of Analysis (COA) available. Store at −20 °C, protected from light and moisture.

This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.

Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.

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Quality & COA

Certificate of Analysis
Lot-specific COA with every order

Certificate of Analysis — lot-specific COA ships with every order and is available on request.

Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.

HPLC purity
≥99% (HPLC)
Method
HPLC + MS
Endotoxin
Reported
[02]

Data Sheet

CAS number175175-23-2
Molecular formulaC₁₅H₂₆N₆O₈
Molecular weight418.40
SequenceGlu-Asp-Arg
Purity≥99% (HPLC)
Physical formWhite lyophilized powder
Quantity10mg/vial
SolubilitySoluble in water
StorageStore at -20°C, protect from light
Shelf life24 months from manufacture date
OriginEU · Slovakia
ClassificationResearch use only
[03]

Scientific References

01 Mendzheritsky AM, Karantysh GV, Ryzhak GA et al.. [Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia]. Adv Gerontol. 2015. PMID: 28509493. PubMed 02 Mendzheritskiĭ AM, Karantysh GV, Ryzhak GA et al.. [Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon]. Adv Gerontol. 2014. PMID: 25051764. PubMed 03 Arutjunyan A, Kozina L, Stvolinskiy S et al.. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012. PMID: 22567179. PubMed 04 Khavinson V, Ribakova Y, Kulebiakin K et al.. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011. PMID: 21978084. doi:10.1089/rej.2011.1172. PubMed 05 Rahman OF, Lee SJ, Seeds WA. Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. J Am Acad Orthop Surg Glob Res Rev. 2026. PMID: 41490200. doi:10.5435/JAAOSGlobal-D-25-00236. PubMed 06 Ilina AR, Popovich IG, Ryzhak GA et al.. [Prospects for use of short peptides in pharmacotherapeutic correction of Alzheimer's disease.]. Adv Gerontol. 2024. PMID: 38944767. PubMed 07 Bel'skaya LV, Gundyrev IA, Solomatin DV. The Role of Amino Acids in the Diagnosis, Risk Assessment, and Treatment of Breast Cancer: A Review. Curr Issues Mol Biol. 2023. PMID: 37754258. doi:10.3390/cimb45090474. PubMed 08 Khavinson V, Linkova N, Kozhevnikova E et al.. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease. Molecules. 2020. PMID: 33396470. doi:10.3390/molecules26010159. PubMed 09 Ulloa-Aguirre A, Reiter E, Bousfield G et al.. Constitutive activity in gonadotropin receptors. Adv Pharmacol. 2014. PMID: 24931192. doi:10.1016/B978-0-12-417197-8.00002-X. PubMed 10 Umnov RS, Lin'kova NS, Khavinson VKh. [Neuroprotective effects of peptides bioregulators in people of various age]. Adv Gerontol. 2013. PMID: 24738258. PubMed 11 Kraskovskaya N, Linkova N, Sakhenberg E et al.. Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes. Int J Mol Sci. 2024. PMID: 39518916. doi:10.3390/ijms252111363. PubMed 12 Zhu X, Cai L, Liu J et al.. Effect of seabuckthorn seed protein and its arginine-enriched peptides on combating memory impairment in mice. Int J Biol Macromol. 2023. PMID: 36706884. doi:10.1016/j.ijbiomac.2023.123409. PubMed 13 Kumar A, Alom SE, Ahari D et al.. Role of Charged Amino Acids in Sullying the Fluorescence of Tryptophan or Conjugated Dansyl Probe in Monomeric Proteins. Biochemistry. 2022. PMID: 35107253. doi:10.1021/acs.biochem.1c00753. PubMed 14 Khavinson V, Ilina A, Kraskovskaya N et al.. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel). 2021. PMID: 34071923. doi:10.3390/ph14060515. PubMed 15 Nagachinta S, Becker G, Dammicco S et al.. Radiolabelling of lipid-based nanocarriers with fluorine-18 for in vivo tracking by PET. Colloids Surf B Biointerfaces. 2020. PMID: 31982792. doi:10.1016/j.colsurfb.2020.110793. PubMed

References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.

[05]

FAQ

Pinealon is a synthetic short peptide bioregulator with the sequence Glu-Asp-Arg (the EDR tripeptide), studied in neuroprotection and cellular-aging research. It belongs to the family of short "peptide bioregulators" investigated for effects reaching the genome in research models. Condor Research supplies it as a 10 mg lyophilized vial at ≥99% HPLC purity, for in-vitro laboratory use only.

Both are short synthetic peptide bioregulators, but they differ in sequence and research framing. Pinealon is the tripeptide Glu-Asp-Arg (EDR), emphasized in neuroprotection research, while Epitalon is the tetrapeptide Ala-Glu-Asp-Gly (AEDG), modelled on the pineal peptide complex and studied in cellular-aging research. Condor Research offers each as a separate ≥99% HPLC, research-use-only reference compound.

Pinealon (Glu-Asp-Arg) is a tripeptide bioregulator studied mainly for neuroprotective mechanisms, whereas Epitalon (Ala-Glu-Asp-Gly) is a tetrapeptide associated with the pineal complex and longevity research. They share the short-peptide-bioregulator class but differ by one residue in length and by research emphasis. Both are supplied as separate ≥99% HPLC, research-use-only reference materials, each with a batch COA.

Pinealon is a Glu-Asp-Arg tripeptide bioregulator studied in neuroprotection and aging research, while P21 (P021) is a synthetic BDNF-mimetic neurotrophic tetrapeptide used in neurodegeneration research. Both carry neuroprotective framing but derive from different concepts — peptide bioregulation versus neurotrophic-factor mimicry. Condor Research supplies each as a distinct ≥99% HPLC, research-use-only reference compound.

Pinealon (Glu-Asp-Arg) is a short peptide bioregulator studied in neuroprotection and cellular-aging contexts, whereas DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide investigated in sleep and neuromodulation research. They address different research questions through unrelated mechanisms. Both are offered as separate ≥99% HPLC, research-use-only reference materials for in-vitro laboratory study.

Pinealon (EDR tripeptide) is selected when a research model is oriented toward neuroprotective mechanisms, while Epitalon (AEDG tetrapeptide) is more associated with cellular-aging and telomere-related research. The choice depends on which short-peptide-bioregulator framing fits your in-vitro study. Both remain research-use-only reference materials with no human or veterinary application.

Yes. The tripeptide sequence Glu-Asp-Arg (CAS 175175-23-2) is verified for each lot by an independent third-party laboratory using HPLC for purity and mass spectrometry for identity. Results are documented on the batch-specific Certificate of Analysis, which can be requested before ordering at info@condorresearch.com.

Yes. Pinealon is supplied strictly for laboratory research use only (in vitro). It is not a medicine, food, supplement, cosmetic, or medical device, and is not for human or veterinary use, administration, or consumption. Condor Research provides no dosing, protocols, or human-use guidance. Purchase is limited to qualified professionals and institutions aged 18 or over.

Yes. Each Pinealon lot is tested by an independent third-party laboratory by HPLC for identity and purity, with mass spectrometry confirmation, and ships against a batch-specific Certificate of Analysis verifying ≥99% purity. To request the COA for the current lot before ordering, contact info@condorresearch.com.

For analytical laboratory preparation only, Pinealon is water-soluble and can be reconstituted with a sterile aqueous diluent; the chosen volume sets the working concentration. Store the sealed lyophilized vial at -20°C, protected from light, with a 24-month shelf life from manufacture. This is laboratory handling information, not guidance for any human or animal use.

[06]

Reviews

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4.7
48 verified reviews
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Apr 2026
High purity, clear labelling

Lyophilised cake was uniform and dissolved fully. Would appreciate a digital COA portal, but the PDF on request worked fine.

Dr. A. Bianchi · University · IT Verified purchase
Mar 2026
Trustworthy supplier

Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.

K. Wójcik · Research group · PL Verified purchase
Mar 2026
Reference-grade consistency

Reconstitution was clean with no visible particulates. The lot-specific COA matched the assay we ran in-house — purity is exactly as stated.

Dr. M. Hartmann · Research lab · DE Verified purchase
Feb 2026
COA matched our own HPLC

We verify every incoming compound by HPLC; this batch came back within tolerance of the certificate. Dispatch from the EU warehouse was quick.

L. Fischer · University group · AT Verified purchase

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