Research use only · EU-warehoused · COA on every batch · HPLC ≥99% · Shipment 2–5 days
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Epitalon

Epitalon

Lyophilised · ≥99% (HPLC) ·

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Supplied lyophilised. Reconstitution typically uses bacteriostatic water.

How to reconstitute Epitalon — stock calculator
Independently third-party tested · COA on every batch · 48h EU dispatch
[01]

Overview

Epitalon (AEDG) is a synthetic tetrapeptide modelled on the pineal peptide epithalamin, developed by Khavinson and studied widely in gerontology, telomere and chronobiology research. CAS 307297-39-8; molecular formula C14H22N4O9; molecular weight approximately 390.35 g/mol; sequence Ala-Glu-Asp-Gly; supplied lyophilised at ≥99% by HPLC. For laboratory research use only.

Modelled on a fragment of the naturally occurring pineal peptide complex epithalamin, Epitalon (also written AEDG, after its amino-acid sequence) is a synthetic tetrapeptide that has become a central reagent in the study of cellular aging. Its remarkable brevity — just four residues — combined with reported bioactivity makes it a favourite probe for researchers investigating telomere biology, circadian gene regulation and oxidative balance.

A four-letter peptide drawn from the pineal gland. The pineal gland secretes regulatory peptides thought to influence the body's aging clock. Decades of Russian gerontology research distilled this activity into a short synthetic sequence, Ala-Glu-Asp-Gly, designed to reproduce key actions of the natural extract in a defined, reproducible form. That lineage places Epitalon among the most studied of the so-called peptide bioregulators.

What the research explores. The experimental record on Epitalon spans several molecular themes, in cell-culture and animal systems:

  • Telomere and telomerase biology — work in human cell lines has reported increases in telomere length attributed to telomerase upregulation (Al-Dulaimi et al., 2025).
  • Gene and protein expression — the AEDG peptide has been shown to modulate gene expression and protein synthesis in experimental models (Khavinson et al., 2020).
  • Antioxidant activity — studies have characterized it as an antioxidant tetrapeptide and examined its role in delayed wound-healing models (Gatta et al., 2025).
  • Free-radical processes — the related pineal preparation has been investigated for effects on free-radical oxidation in animals and humans (Anisimov et al., 2001).

Every one of these findings arises from in‑vitro or animal research and carries no implication for human application. Full citations are listed under the Scientific References tab.

Physicochemical profile. CAS 307297-39-8 · Molecular formula C14H22N4O9 · Molecular weight 390.34 g/mol · Sequence Ala-Glu-Asp-Gly · Appearance white lyophilized powder · Soluble in water.

Specification & quality. Each individually sealed vial contains 10 mg of Epitalon at ≥99% purity by HPLC. Every batch is third-party tested, with a Certificate of Analysis (COA) available. Store at −20 °C, protected from light and moisture.

This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.

Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.

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Quality & COA

Certificate of Analysis
Lot-specific COA with every order

Certificate of Analysis — lot-specific COA ships with every order and is available on request.

Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.

HPLC purity
≥99% (HPLC)
Method
HPLC + MS
Endotoxin
Reported
[02]

Data Sheet

CAS number307297-39-8
Molecular formulaC14H22N4O9
Molecular weight390.34
SequenceAla-Glu-Asp-Gly
Purity≥99% (HPLC)
Physical formWhite lyophilized powder
Quantity10mg/vial
SolubilitySoluble in water
StorageStore at -20°C, protect from light
ReconstitutionReconstitute with bacteriostatic water or sterile saline.
Shelf life24 months from manufacture date
OriginEU · Slovakia
ClassificationResearch use only
[03]

Scientific References

01 Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. International journal of molecular sciences. 2025;26(6). PMID: 40141333. doi:10.3390/ijms26062691. PubMed 02 Khavinson VKh, Morozov VG [Geroprotective effect of thymalin and epithalamin]. Advances in gerontology = Uspekhi gerontologii. 2002;10:74-84. PMID: 12577695. PubMed 03 Anisimov VN, Arutjunyan AV, Khavinson VK Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals. Neuro endocrinology letters. 2001;22(1):9-18. PMID: 11335874. PubMed 04 Anisimov VN, Khavinson VKh, Morozov VG Twenty years of study on effects of pineal peptide preparation: epithalamin in experimental gerontology and oncology. Annals of the New York Academy of Sciences. 1994;719:483-93. PMID: 8010617. doi:10.1111/j.1749-6632.1994.tb56853.x. PubMed 05 Anisimov VN, Prokopenko VM, Khavinson VKh [Melatonin and epithalamin inhibit the process of free radical oxidation in rats]. Doklady Akademii nauk. 1995;343(4):557-9. PMID: 7580986. PubMed 06 Al-Dulaimi S, Thomas R, Matta S, Roberts T Correction: Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025;27(1):1. PMID: 41240216. doi:10.1007/s10522-025-10326-8. PubMed 07 Gatta M, Dovizio M, Milillo C, Ruggieri AG, Sallese M, Antonucci I et al. The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy. Stem cell reviews and reports. 2025;21(6):1822-1834. PMID: 40493162. doi:10.1007/s12015-025-10911-x. PubMed 08 Ullah S, Haider Z, Perera CD, Lee SH, Idrees M, Park S et al. Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development. Life sciences. 2025;362:123381. PMID: 39788414. doi:10.1016/j.lfs.2025.123381. PubMed 09 Yue X, Liu SL, Guo JN, Meng TG, Zhang XR, Li HX et al. Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro. Aging. 2022;14(7):3191-3202. PMID: 35413689. doi:10.18632/aging.204007. PubMed 10 Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules (Basel, Switzerland). 2020;25(3). PMID: 32019204. doi:10.3390/molecules25030609. PubMed 11 Ivko OM, Drobintseva AO, Leont'eva DO, Kvetnoy IM, Polyakova VO, Linkova NS [The influence of AEDG and KE peptides on mitochondries stain and L7A ribosomes protein expression during human pineal gland and thymus cell senescence in vitro.]. Advances in gerontology = Uspekhi gerontologii. 2020;33(4):741-747. PMID: 33342107. PubMed 12 Ivko OM, Linkova NS, Ilina AR, Sharova AA, Ryzhak GA [AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.]. Advances in gerontology = Uspekhi gerontologii. 2020;33(3):429-435. PMID: 33280326. PubMed 13 Vanhee C, Moens G, Van Hoeck E, Deconinck E, De Beer JO Identification of the small research tetra peptide Epitalon, assumed to be a potential treatment for cancer, old age and Retinitis Pigmentosa in two illegal pharmaceutical preparations. Drug testing and analysis. 2015;7(3):259-64. PMID: 25535022. doi:10.1002/dta.1771. PubMed 14 Korenevsky AV, Milyutina YP, Bukalyov AV, Baranova YP, Vinogradova IA, Arutjunyan AV [Protective effect of melatonin and epithalon on hypothalamic regulation of reproduction in female rats in its premature aging model and on estrous cycles in senescent animals in various lighting regimes]. Advances in gerontology = Uspekhi gerontologii. 2013;26(2):263-274. PMID: 28976150. PubMed 15 Zamorskii II, Sopova IY, Khavinson VKh Effects of melatonin and epithalamin on the content of protein and lipid peroxidation products in rat cortex and hippocampus under conditions of acute hypoxia. Bulletin of experimental biology and medicine. 2012;154(1):51-3. PMID: 23330089. doi:10.1007/s10517-012-1873-7. PubMed

References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.

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FAQ

Epitalon (also written AEDG, after its Ala-Glu-Asp-Gly sequence) is a synthetic tetrapeptide modelled on a fragment of the naturally occurring pineal peptide complex epithalamin. It has become a central reagent in cellular-aging research. Condor Research supplies it as a 10 mg lyophilized vial at ≥99% HPLC purity, strictly as a research-use-only reference material for in-vitro study.

Epitalon and Pinealon are both short pineal-related synthetic peptides but differ in sequence and research framing. Epitalon is the tetrapeptide Ala-Glu-Asp-Gly (AEDG), studied as a reagent in cellular-aging and longevity research. Pinealon is the tripeptide Glu-Asp-Arg, framed more around neuroprotective research. Both are supplied as separate ≥99% HPLC, research-use-only reference peptides.

The distinction reflects how each peptide is studied, not a claimed effect. Epitalon (AEDG) is widely used as a reference reagent in cellular-aging and longevity research models. Pinealon (Glu-Asp-Arg) appears more often in neuroprotective research contexts. Both are short peptide bioregulators sold as ≥99% HPLC research-use-only materials for in-vitro laboratory work only.

They are different classes of molecule used in longevity research. Epitalon is a synthetic tetrapeptide (AEDG) studied as a peptide reference reagent. NAD+ is a fundamental coenzyme central to cellular energy metabolism, supplied as a high-mass 1000 mg vial. Researchers select between a defined peptide and a metabolic cofactor based on the pathway under study. Both are research-use-only.

Epitalon and DSIP are distinct peptides occasionally grouped under pineal/circadian biology. Epitalon is the tetrapeptide Ala-Glu-Asp-Gly, studied in cellular-aging research. DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide studied in sleep and neuroregulatory research. They differ in sequence, size, and research focus, and each is supplied as a separate ≥99% HPLC, research-use-only reference peptide.

Epitalon is supplied strictly as a research-use-only reference compound for in-vitro laboratory study; it is not a medicine, supplement, or anti-aging product, and is not for human or veterinary use, administration, or consumption. It is used by researchers as a reagent in cellular-aging studies. Condor Research makes no therapeutic or wellness claims and provides no human-use guidance.

Yes. Epitalon is supplied strictly for laboratory research use only (in vitro). It is not a medicine, food, supplement, cosmetic, or medical device, and is not for human or veterinary use, administration, or consumption. Condor Research provides no dosing or protocols. Purchase is restricted to qualified professionals and institutions aged 18 or over.

For analytical laboratory preparation only, Epitalon is water-soluble and can be reconstituted with a sterile aqueous diluent; the volume chosen sets the working concentration. Store the sealed lyophilized vial at -20°C, protected from light, with a 24-month shelf life from manufacture. This is laboratory handling information, not guidance for any human or animal use.

Yes. Each Epitalon lot is tested by an independent third-party laboratory by HPLC for identity and purity, with mass spectrometry confirmation, and ships against a batch-specific Certificate of Analysis (COA) verifying ≥99% purity. To request the COA for the current lot before ordering, contact info@condorresearch.com.

Each Epitalon vial contains 10 mg of lyophilized peptide at ≥99% HPLC purity, supplied as a research-use-only reference material. The stated mass is an analytical reference quantity, not a dose. Vial fill and identity are verified by independent third-party testing and documented on the lot's Certificate of Analysis.

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Reviews

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4.7
78 verified reviews
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Apr 2026
Reference-grade consistency

Reconstitution was clean with no visible particulates. The lot-specific COA matched the assay we ran in-house — purity is exactly as stated.

Dr. M. Hartmann · Research lab · DE Verified purchase
Mar 2026
COA matched our own HPLC

We verify every incoming compound by HPLC; this batch came back within tolerance of the certificate. Dispatch from the EU warehouse was quick.

L. Fischer · University group · AT Verified purchase
Mar 2026
Impeccable packaging

Cold-chain handling was respected end to end. Vials arrived sealed, labelled and intact. Documentation is the most thorough I've seen from an EU supplier.

Dr. S. Novak · Private lab · CZ Verified purchase
Feb 2026
Reliable, well documented

Solubility and stability were as described. Knocked one star only because express shipping options are limited, but quality is not in question.

P. Andersson · Research institute · SE Verified purchase

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