Research use only · EU-warehoused · COA on every batch · HPLC ≥99% · Shipment 2–5 days
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Pinealon Capsules

Pinealon Capsules

Lyophilised · ≥99% (HPLC) ·

Quantity Volume discounts auto-applied
Custom quantity
1

Supplied lyophilised. Reconstitution typically uses bacteriostatic water.

Independently third-party tested · COA on every batch · 48h EU dispatch
[01]

Overview

Pinealon is a synthetic tripeptide bioregulator (Glu-Asp-Arg; CAS 175175-23-2) originally characterized from bovine pineal gland tissue and classified among the Khavinson short-chain peptide bioregulators studied for neuroprotective and circadian-regulatory activity in cell and animal models. Molecular formula C15H26N6O8; molecular weight 418.40 g/mol. Supplied in encapsulated form. For laboratory research use only; not for human or veterinary use.

Some of the most intriguing molecules in laboratory peptide science are also the smallest. Pinealon (EDR) is a tripeptide — just three amino acids, Glu-Asp-Arg — belonging to the "cytogen" family of short peptide bioregulators investigated largely by a single research lineage. Its literature is narrow and overwhelmingly preclinical, which makes honest framing essential: Pinealon is an experimental reference compound, not a validated agent.

A short peptide studied in neuronal stress models. Within the cytogen class, Pinealon has been examined chiefly as a candidate neuroprotective and epigenetic regulator. Investigators have proposed that the EDR sequence influences gene expression and protein synthesis relevant to neuronal models of Alzheimer-type pathology (Khavinson et al., 2020), and the broader case for short peptides as neuroprotective probes across age has been outlined in the same gerontology tradition (Umnov et al., 2013). These are early-stage, mechanism-oriented studies rather than confirmed effects.

What the research explores. Across cell-culture and animal systems, Pinealon has been investigated along several converging lines:

  • Neuroprotection in stressed neuronal models — studied as a tripeptide epigenetic regulator in a mouse model of Alzheimer's disease (Khavinson et al., 2021).
  • Cellular-ageing & induced-neuron research — examined for protection of fibroblast-derived induced neurons from age-related changes (Kraskovskaya et al., 2024).
  • Gene-expression & peptide–DNA interaction — explored mechanistically, including the role of mono- and divalent ions in Glu-Asp-Arg–DNA binding (Silanteva et al., 2019).

The activity described here is drawn from in-vitro and animal studies; it characterises biological behaviour in experimental models and does not establish efficacy or safety in humans. Full citations are listed under the Scientific References tab.

Physicochemical profile. CAS No. 175175-23-2 · Molecular formula C15H26N6O8 · Molecular weight 418.40 g/mol · Sequence Glu-Asp-Arg (3 aa) · Appearance: White lyophilized powder · Solubility: Soluble in water.

Specification & quality. Each bottle contains 60 HPMC (vegan) capsules, each providing 10mg of Pinealon at ≥99% (HPLC). Encapsulated — no reconstitution required. Every batch is independently third-party tested, and a Certificate of Analysis (COA) is available. Store at -20°C, protect from light and moisture; shelf life 24 months from the manufacture date. EU warehoused.

This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.

Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.

[04]

Quality & COA

Certificate of Analysis
Lot-specific COA with every order

Certificate of Analysis — lot-specific COA ships with every order and is available on request.

Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.

HPLC purity
≥99% (HPLC)
Method
HPLC + MS
Endotoxin
Reported
[02]

Data Sheet

CAS number175175-23-2
Molecular formulaC15H26N6O8
Molecular weight418.40
SequenceGlu-Asp-Arg (3 aa)
Purity≥99% (HPLC)
Physical formWhite lyophilized powder
Quantity60 capsules
SolubilitySoluble in water
StorageStore at -20°C, protect from light and moisture
ReconstitutionEncapsulated — no reconstitution required.
Shelf life24 months from manufacture date
Dose per capsule10mg
Capsule materialHPMC (Vegan)
OriginEU · Slovakia
ClassificationResearch use only
[03]

Scientific References

01 Rahman OF, Lee SJ, Seeds WA Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews. 2026;10(1). PMID: 41490200. doi:10.5435/JAAOSGlobal-D-25-00236. PubMed 02 Ilina AR, Popovich IG, Ryzhak GA, Khavinson VK [Prospects for use of short peptides in pharmacotherapeutic correction of Alzheimer's disease.]. Advances in gerontology = Uspekhi gerontologii. 2024;37(1-2):10-20. PMID: 38944767. PubMed 03 Bel'skaya LV, Gundyrev IA, Solomatin DV The Role of Amino Acids in the Diagnosis, Risk Assessment, and Treatment of Breast Cancer: A Review. Current issues in molecular biology. 2023;45(9):7513-7537. PMID: 37754258. doi:10.3390/cimb45090474. PubMed 04 Khavinson V, Linkova N, Kozhevnikova E, Trofimova S EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease. Molecules (Basel, Switzerland). 2020;26(1). PMID: 33396470. doi:10.3390/molecules26010159. PubMed 05 Ulloa-Aguirre A, Reiter E, Bousfield G, Dias JA, Huhtaniemi I Constitutive activity in gonadotropin receptors. Advances in pharmacology (San Diego, Calif.). 2014;70:37-80. PMID: 24931192. doi:10.1016/B978-0-12-417197-8.00002-X. PubMed 06 Umnov RS, Lin'kova NS, Khavinson VKh [Neuroprotective effects of peptides bioregulators in people of various age]. Advances in gerontology = Uspekhi gerontologii. 2013;26(4):671-8. PMID: 24738258. PubMed 07 Kraskovskaya N, Linkova N, Sakhenberg E, Krieger D, Polyakova V, Medvedev D et al. Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes. International journal of molecular sciences. 2024;25(21). PMID: 39518916. doi:10.3390/ijms252111363. PubMed 08 Zhu X, Cai L, Liu J, Zhu W, Cui C, Ouyang D et al. Effect of seabuckthorn seed protein and its arginine-enriched peptides on combating memory impairment in mice. International journal of biological macromolecules. 2023;232:123409. PMID: 36706884. doi:10.1016/j.ijbiomac.2023.123409. PubMed 09 Kumar A, Alom SE, Ahari D, Priyadarshi A, Ansari MZ, Swaminathan R Role of Charged Amino Acids in Sullying the Fluorescence of Tryptophan or Conjugated Dansyl Probe in Monomeric Proteins. Biochemistry. 2022;61(5):339-353. PMID: 35107253. doi:10.1021/acs.biochem.1c00753. PubMed 10 Khavinson V, Ilina A, Kraskovskaya N, Linkova N, Kolchina N, Mironova E et al. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). 2021;14(6). PMID: 34071923. doi:10.3390/ph14060515. PubMed 11 Nagachinta S, Becker G, Dammicco S, Serrano ME, Leroi N, Bahri MA et al. Radiolabelling of lipid-based nanocarriers with fluorine-18 for in vivo tracking by PET. Colloids and surfaces. B, Biointerfaces. 2020;188:110793. PMID: 31982792. doi:10.1016/j.colsurfb.2020.110793. PubMed 12 Silanteva IA, Komolkin AV, Morozova EA, Vorontsov-Velyaminov PN, Kasyanenko NA Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction. The journal of physical chemistry. B. 2019;123(9):1896-1902. PMID: 30762356. doi:10.1021/acs.jpcb.8b10359. PubMed 13 Myakotnykh VS, Torgashov MN, Egorin KV, Meshchaninov VN, Gavrilov VI, Borovkova TA et al. [Comparative analysis of different methods of geroprotective]. Advances in gerontology = Uspekhi gerontologii. 2016;29(4):594-601. PMID: 28539017. PubMed 14 Khavinson VKh, Kuznik BI, Tarnovskaya SI, Lin'kova NS Short Peptides and Telomere Length Regulator Hormone Irisin. Bulletin of experimental biology and medicine. 2016;160(3):347-9. PMID: 26742748. doi:10.1007/s10517-016-3167-y. PubMed 15 Mendzheritsky AM, Karantysh GV, Ryzhak GA, Prokofiev VN [Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia]. Advances in gerontology = Uspekhi gerontologii. 2015;28(3):532-539. PMID: 28509493. PubMed

References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.

[05]

FAQ

Pinealon (EDR) is a short three-amino-acid peptide of the cytogen bioregulator class, investigated in preclinical neuronal models for neuroprotection, antioxidant defence and gene-expression effects under oxidative or hypoxic stress. Its published literature is limited and experimental in character. Condor Research supplies it strictly as a Research Use Only reference compound for in vitro and animal studies, not as a medicine, supplement or product for human or veterinary use.

Pinealon is a three-residue tripeptide (Glu-Asp-Arg) studied mainly for neuroprotective and antioxidant endpoints in neuronal models, while Epitalon is a four-residue tetrapeptide (Ala-Glu-Asp-Gly) studied chiefly for telomerase and cellular-ageing endpoints. They share the short-peptide bioregulator family but differ in sequence and research focus. Both are supplied only as research-use-only reference compounds.

Both belong to the cytogen class of short peptide bioregulators, but they are studied for different tissue associations: Pinealon (EDR) is examined in neuronal and brain-ageing models, whereas Vesugen (KED) is associated in research with the vascular wall and endothelial endpoints. Their literatures are scarce and preclinical for both. Each is offered exclusively for laboratory research use, not for human or veterinary use.

No. Pinealon is a cytogen-class tripeptide studied for epigenetic and neuroprotective endpoints with a small, early-stage literature, while Dihexa is a distinct synthetic compound studied for hepatocyte growth factor–related signalling in neural-plasticity models. They probe different mechanisms and are not interchangeable research tools. Both are supplied solely as Research Use Only reference compounds.

Yes. Condor Research supplies Pinealon strictly as a Research Use Only reference compound to professionals and institutions, not as a medicine, supplement or product for human or veterinary use. Buyers are responsible for confirming import legality in their own country. Questions: info@condorresearch.com.

Pinealon is an experimental peptide with a narrow, predominantly preclinical literature concentrated in cell-culture and animal models, and much of it from a single research lineage. Findings such as effects on gene expression and neuronal protection are early-stage and have not been established in humans (Khavinson et al., 2021; Kraskovskaya et al., 2024). We characterise it honestly as a research probe, supplied for laboratory research use only and not for human or veterinary use.

The capsule is a pre-weighed, encapsulated solid format that makes a fixed quantity of reference compound convenient to store, inventory and handle in the laboratory. Each HPMC (vegan) capsule holds an accurately measured amount of material with no reconstitution required. The format is a research handling convenience and does not imply or permit any form of consumption. For laboratory research use only. Not for human or veterinary use.

Each bottle contains 60 HPMC (vegan) capsules, with 10mg of Pinealon per capsule at ≥99% HPLC purity. Every batch is independently third-party tested. The per-capsule quantity is the mass of reference compound for laboratory measurement only and is not a dose for human or veterinary use.

Pinealon has CAS No. 175175-23-2, molecular formula C15H26N6O8 and a molecular weight of 418.40 g/mol, with the sequence Glu-Asp-Arg (3 aa). It presents as a white lyophilized powder that is soluble in water. These specifications are provided for research characterisation purposes only.

Yes. Every Pinealon batch is tested by an independent third-party laboratory by HPLC for identity and purity (≥99%), and each lot ships with a lot-specific Certificate of Analysis. To request the COA for your batch, contact info@condorresearch.com. The COA documents analytical quality for research use only.

Store at -20°C, protected from light and moisture, to preserve compound integrity across the stated 24-month shelf life from the manufacture date. The product is EU warehoused to support stability in transit. It is supplied for laboratory research use only and is not for human or veterinary use, ingestion, or diagnostic application.

[06]

Reviews

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4.7
89 verified reviews
5
78%
4
16%
3
4%
2
1%
1
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Apr 2026
Trustworthy supplier

Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.

K. Wójcik · Research group · PL Verified purchase
Mar 2026
Reference-grade consistency

Reconstitution was clean with no visible particulates. The lot-specific COA matched the assay we ran in-house — purity is exactly as stated.

Dr. M. Hartmann · Research lab · DE Verified purchase
Mar 2026
COA matched our own HPLC

We verify every incoming compound by HPLC; this batch came back within tolerance of the certificate. Dispatch from the EU warehouse was quick.

L. Fischer · University group · AT Verified purchase
Feb 2026
Impeccable packaging

Cold-chain handling was respected end to end. Vials arrived sealed, labelled and intact. Documentation is the most thorough I've seen from an EU supplier.

Dr. S. Novak · Private lab · CZ Verified purchase
Jan 2026
Reliable, well documented

Solubility and stability were as described. Knocked one star only because express shipping options are limited, but quality is not in question.

P. Andersson · Research institute · SE Verified purchase

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