Lyophilised · ≥98% (HPLC) ·
Supplied lyophilised. Reconstitution typically uses bacteriostatic water.
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a synthetic peptidomimetic derived from angiotensin IV, designed for metabolic stability and blood-brain barrier penetration, and studied for its potent HGF/c-Met signalling activity in cognitive and neuroprotective research models. CAS 1401708-83-5; molecular formula C27H44N4O5; molecular weight 504.7 g/mol. Supplied encapsulated at HPLC ≥99% purity. For laboratory research use only; not for human or veterinary use.
Engineered from a fragment of the brain's own angiotensin system and rebuilt for metabolic stability, Dihexa (PNB-0408) is a small peptidomimetic that has become a touchstone in synaptogenesis research. Rather than acting as a classical neurotransmitter, it is studied for its ability to engage the hepatocyte growth factor (HGF) / c-Met system — a signalling axis tied to the formation of new synaptic connections in laboratory models.
A peptidomimetic built from angiotensin IV. Dihexa belongs to a lineage of angiotensin-IV-derived analogs developed specifically to survive metabolic breakdown while retaining procognitive activity in experimental systems (McCoy et al., 2013). Its defining mechanistic claim is that the procognitive and synaptogenic effects of this analog class depend on activation of the HGF/c-Met system rather than on direct angiotensin-receptor signalling (Benoist et al., 2014).
Because it is a modified dipeptide rather than a standard peptide sequence, Dihexa has been positioned in drug-discovery reviews as a small-molecule angiotensin-IV analog of interest for neurodegeneration models (Wright et al., 2015).
What the research explores. Across cell-culture and animal systems, Dihexa has been investigated along several converging lines:
The activity described here is drawn from in-vitro and animal studies; it characterises biological behaviour in experimental models and does not establish efficacy or safety in humans. Full citations are listed under the Scientific References tab.
Physicochemical profile. CAS No. 1401708-83-5 · Molecular formula C27H44N4O5 · Molecular weight 504.67 g/mol · Appearance: White to off-white powder · Solubility: Soluble in DMSO.
Specification & quality. Each bottle contains 60 HPMC (vegan) capsules, each providing 5mg of Dihexa at ≥98% (HPLC). Encapsulated — no reconstitution required. Every batch is independently third-party tested, and a Certificate of Analysis (COA) is available. Store at room temperature, protect from light and moisture; shelf life 24 months from the manufacture date. EU warehoused.
This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.
Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.
Certificate of Analysis — lot-specific COA ships with every order and is available on request.
Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.
References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.
Dihexa (PNB-0408) is a metabolically stabilised, angiotensin-IV-derived peptidomimetic studied in cell and rodent models for procognitive and synaptogenic activity linked to the HGF/c-Met system (Benoist et al., 2014). Condor Research supplies it strictly as a Research Use Only reference compound for in vitro and animal studies, not as a medicine or supplement for human or veterinary use.
Many research nootropics act on neurotransmitter or receptor systems, whereas Dihexa is studied as an HGF/c-Met–dependent synaptogenic agent, with its procognitive effects reported to require activation of that growth-factor pathway (Benoist et al., 2014). This makes it a tool for distinct research questions about synapse formation rather than neurotransmission. Both classes are supplied only as research-use-only reference compounds.
Dihexa emerged from a program designed to produce metabolically stabilised angiotensin-IV analogs that retain procognitive activity in experimental models (McCoy et al., 2013). Its stability and small-molecule character distinguish it within that analog family for neurodegeneration research (Wright et al., 2015). All such analogs are offered strictly for laboratory research, never for human or veterinary use.
Hepatocyte growth factor (HGF) is a large native protein, while Dihexa is a small peptidomimetic studied as an HGF mimetic that engages the c-Met receptor, for example protecting lateral-line hair cells in a model system (Uribe et al., 2015). Researchers use the small molecule when a stable, defined reagent is preferred over the full protein. Each is supplied for research use only, not for human or veterinary use.
Semax is an ACTH-derived peptide studied largely through BDNF-related pathways, whereas Dihexa is an angiotensin-IV-derived peptidomimetic whose synaptogenic activity is tied to HGF/c-Met signalling (Benoist et al., 2014). They represent different molecular classes addressing different research questions. Both are provided strictly as research-use-only reference compounds.
Yes. Condor Research supplies Dihexa strictly as a Research Use Only reference compound to professionals and institutions, not as a medicine, supplement or product for human or veterinary use. Buyers are responsible for confirming import legality in their own country. Questions: info@condorresearch.com.
The capsule is a pre-weighed solid format that makes a fixed 5mg quantity of Dihexa powder easy to store and handle in the laboratory, using HPMC (vegan) shells. It is not a dose for consumption and does not imply ingestion. The capsule format is provided strictly for research use only; not for human or veterinary use.
No. Each capsule already contains pre-weighed solid Dihexa powder, so no reconstitution is required for laboratory handling. For in vitro work, researchers may dissolve the contents in an appropriate solvent such as DMSO. This product is for research use only and not for human or veterinary use.
Each bottle contains 60 HPMC (vegan) capsules, with each capsule providing 5mg of Dihexa at ≥98% (HPLC) purity. Every batch is independently third-party tested. The capsules are a pre-measured solid format for laboratory research use only, not a dose for human or veterinary use.
Dihexa has the molecular formula C27H44N4O5, a molecular weight of 504.67 g/mol, and CAS number 1401708-83-5. It presents as a white to off-white powder, soluble in DMSO. It is supplied strictly as a research-use-only reference compound.
Yes. Every Dihexa batch is tested by an independent third-party laboratory by HPLC for identity and purity (≥98%), and ships with a lot-specific Certificate of Analysis. To request the COA for a particular lot, contact info@condorresearch.com. For laboratory research use only. Not for human or veterinary use.
Reconstitution was clean with no visible particulates. The lot-specific COA matched the assay we ran in-house — purity is exactly as stated.
We verify every incoming compound by HPLC; this batch came back within tolerance of the certificate. Dispatch from the EU warehouse was quick.
Cold-chain handling was respected end to end. Vials arrived sealed, labelled and intact. Documentation is the most thorough I've seen from an EU supplier.
Solubility and stability were as described. Knocked one star only because express shipping options are limited, but quality is not in question.
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