Plain-spoken notes on the compounds we supply — what the literature shows, how to read a COA, and the protocols that protect your data. Cited, never hyped.
Metabolic & longevity
Tesofensine (NS2330) is a small-molecule triple monoamine reuptake inhibitor that produced some of the largest weight-loss figures of the pre-GLP-1 era in human obesity…
Metabolic & longevity
A synthetic pan-agonist of the estrogen-related receptors, studied as an “exercise mimetic” that switches on the oxidative-metabolism programme a workout normally triggers. Here is…
Metabolic & longevity
NMN is a direct precursor of NAD+, the metabolic coenzyme that fades with age. It is the molecule the anti-ageing field bet on to…
Metabolic & longevity
Two synthetic peptides that are almost always studied as a pair: one mimics ghrelin, the other mimics GHRH. A research primer on how each…
Metabolic & longevity
5-Amino-1MQ is a small-molecule inhibitor of the enzyme NNMT, studied in cells and obese mice for its effects on the NAD+ and methylation economy…
Metabolic & longevity
How metabolic research moved from a single receptor to two to three — and what each added hormone receptor changed in the preclinical and…
Metabolic & longevity
A four-letter peptide carries a decades-old case of mistaken identity. A 2026 re-examination argues the famous dose was never Epitalon's at all — and…
Metabolic & longevity
Retatrutide (LY3437943) is a single engineered peptide built to pull three metabolic levers at once. Here is what the science actually shows — and…
Occasional, considered notes on the compounds and the literature. No noise.
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