Lyophilised · ≥99% (HPLC) ·
Supplied lyophilised. Reconstitution typically uses bacteriostatic water.
Hidden inside a large repair protein is a tiny fragment that the body cleaves out and uses on its own. TB-500 (Frag) is the synthetic acetylated tetrapeptide Ac-Ser-Asp-Lys-Pro (Ac-SDKP, also called goralatide), a naturally occurring fragment released from thymosin β4. Rather than the full thymosin β4 molecule, this listing is the short Ac-SDKP sequence itself — one of the most studied antifibrotic and anti-inflammatory peptide fragments in the literature.
A fragment with a life of its own. Ac-SDKP is generated endogenously from thymosin β4 through the action of prolyl oligopeptidase and is regulated within the renin-angiotensin system, where angiotensin-converting enzyme (ACE) is a primary route of its degradation (Kassem et al., 2019). Because ACE inhibition raises Ac-SDKP levels, the peptide sits at an intersection of cardiovascular and tissue-remodeling biology, making it a focused tool for fibrosis research distinct from full-length thymosin β4.
What the research explores. The literature concentrates on anti-fibrotic and anti-inflammatory endpoints:
These findings derive from in vitro and animal research describing biological activity; they do not establish safety or efficacy in humans. Full citations are listed under the Scientific References tab.
Physicochemical profile. CAS 120081-14-3 · Molecular formula C₂₀H₃₃N₅O₉ · Molecular weight 487.5 g/mol · Sequence Ac-Ser-Asp-Lys-Pro · Appearance: white lyophilized powder · Soluble in water.
Specification & quality. Each individually sealed vial contains 2 mg of TB-500 (Frag) — Ac-SDKP — as a white lyophilized powder at ≥99% purity by HPLC. Every batch is third-party tested, with a Certificate of Analysis (COA) available. Store at −20 °C, protected from light and moisture.
This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.
Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.
Certificate of Analysis — lot-specific COA ships with every order and is available on request.
Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.
References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.
TB-500 (Frag) is the synthetic tetrapeptide Ac-Ser-Asp-Lys-Pro (Ac-SDKP, also known as goralatide), a small fragment that the body cleaves from a larger thymosin β4 precursor and that acts on its own in research models. Condor Research supplies it as a 2 mg lyophilized vial at ≥99% HPLC purity, strictly for in-vitro laboratory research use only.
They are different molecules. TB-500 (Frag) is the four-residue Ac-SDKP (goralatide) tetrapeptide, whereas the standard TB-500 product is the much larger 43-residue actin-binding fragment derived from thymosin β4. The Frag isolates one short, naturally cleaved sequence rather than the full peptide. Condor Research offers each as a separate ≥99% HPLC, research-use-only reference compound, each with its own COA.
TB-500 (Frag) is the small Ac-SDKP tetrapeptide and is offered as a 2 mg vial, while the larger 43-residue TB-500 is supplied at 10 mg; the masses are analytical reference quantities for two distinct molecules, not doses. To compare value per mg or for current pricing, contact info@condorresearch.com. Both are ≥99% HPLC research-use-only materials.
TB-500 (Frag) isolates the single Ac-Ser-Asp-Lys-Pro (goralatide) sequence, a defined cleavage product, whereas full-length TB-500 is the 43-residue actin-binding fragment with broader structural features. Researchers choose the Frag to study that one short motif specifically. Both are supplied as separate ≥99% HPLC, research-use-only reference compounds; selection depends on your in-vitro research question.
TB-500 (Frag) is the Ac-SDKP tetrapeptide derived from thymosin β4 biology, while BPC-157 is a 15-residue gastric pentadecapeptide studied for cytoprotective mechanisms. They are both short peptides in regenerative research but have unrelated sequences and pathways. Condor Research offers each as a distinct ≥99% HPLC, research-use-only reference compound; the choice depends on your experimental target.
TB-500 (Frag) is selected when the focus is specifically the Ac-SDKP (goralatide) tetrapeptide as an isolated, naturally cleaved sequence, rather than the broader 43-residue thymosin β4 fragment. Researchers studying that short motif on its own choose the Frag. Both remain research-use-only reference materials with no human or veterinary application.
Yes. The acetylated tetrapeptide Ac-Ser-Asp-Lys-Pro (CAS 120081-14-3) is verified for each lot by an independent third-party laboratory using HPLC for purity and mass spectrometry for identity, confirming both the sequence and N-terminal acetylation. Results are documented on the batch-specific Certificate of Analysis, available on request at info@condorresearch.com.
Yes. TB-500 (Frag) is supplied strictly for laboratory research use only (in vitro). It is not a medicine, food, supplement, cosmetic, or medical device, and is not for human or veterinary use, administration, or consumption. Condor Research provides no dosing, protocols, or human-use guidance. Purchase is limited to qualified professionals and institutions aged 18 or over.
Yes. Each TB-500 (Frag) lot is tested by an independent third-party laboratory by HPLC for identity and purity, with mass spectrometry confirmation, and ships against a batch-specific Certificate of Analysis verifying ≥99% purity. To request the COA for the current lot before ordering, contact info@condorresearch.com.
For analytical laboratory preparation only, TB-500 (Frag) is water-soluble and can be reconstituted with a sterile aqueous diluent; with a 2 mg vial the chosen volume sets the working concentration. Store the sealed lyophilized vial at -20°C, protected from light, with a 24-month shelf life. This is laboratory handling information, not guidance for any human or animal use.
Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.
Reconstitution was clean with no visible particulates. The lot-specific COA matched the assay we ran in-house — purity is exactly as stated.
We verify every incoming compound by HPLC; this batch came back within tolerance of the certificate. Dispatch from the EU warehouse was quick.
Cold-chain handling was respected end to end. Vials arrived sealed, labelled and intact. Documentation is the most thorough I've seen from an EU supplier.
Solubility and stability were as described. Knocked one star only because express shipping options are limited, but quality is not in question.
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