Encapsulated · ≥99% (HPLC) ·
Supplied as encapsulated research material. Laboratory preparation depends on the experimental protocol.
Format: pre-weighed capsules, 60 × 500 mcg. Each HPMC capsule seals the same 500 mcg of solid TB-500 (Ac-LKKTETQ, thymosin β4 residues 17–23), so every unit in the bottle (30 mg in total) is an identical analytical reference quantity. If your work starts from a single quantity in solution, the separate TB-500 (Frag) 2 mg lyophilised vial is the format to use. For laboratory research use only. Not for human or veterinary use.
When a cell needs to move, rebuild a wound edge, or sprout a new vessel, it first has to remodel its own internal scaffolding — and that scaffolding is actin. TB-500 in this product is the synthetic, N-terminally acetylated heptapeptide Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ): residues 17–23 of thymosin β4, the central motif through which that 43-residue protein interacts with actin. It is the same molecule as the TB-500 (Frag) vial, presented here as a pre-weighed solid; it is not the full-length thymosin β4 that Condor Research sells as TB-500 (10 mg vial).
A seven-residue motif drawn from an actin-binding protein. Thymosin β4 is one of the most abundant actin-binding proteins in many cell types, and its expression has been mapped across human organ development (Faa et al., 2024). Peptide-mapping work localises the protein’s pro-migratory and angiogenic activity to the LKKTETQ region, separately from the N-terminal Ac-SDKP sequence (Sosne et al., 2010) — which is why this short motif is used as a probe of actin-linked cell motility.
What the research explores. The heptapeptide’s own literature is small, and most of it used the non-acetylated sequence:
Most organ-level work — cardiac remodelling, corneal repair, kidney disease, graft survival — concerns full-length thymosin β4, the parent protein, not this fragment (Maar et al., 2025; Nguyen et al., 2025; Di et al., 2026; Zhang et al., 2025). Human studies, such as a recombinant thymosin β4 cohort after myocardial infarction, likewise used the full protein (Zhang et al., 2025). In a fibroblast assay, Rahaman et al. (2024) found significant wound-closure activity only for the metabolite Ac-LKKTE, not for the acetylated heptapeptide itself. There are no human data for Ac-LKKTETQ, and nothing here establishes efficacy or safety in humans. Full citations are listed under the Scientific References tab.
Which “TB-500” is which. The name is used in the market for more than one molecule; sequence, mass and CAS number, not the trade name, identify what is in the vial.
| Condor Research product | Molecule | Sequence | Length | MW (g/mol) | CAS |
|---|---|---|---|---|---|
| TB-500 (Frag); TB-500 Capsules; the TB-500 in BPC-157 + TB-500, GLOW, KLOW and BPC-157 Arginate + TB-500 Capsules | Thymosin β4 fragment 17–23, N-acetylated | Ac-LKKTETQ | 7 aa | 889.0 | 885340-08-9 |
| TB-500 (10 mg vial) | Full-length thymosin β4 | Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES | 43 aa | 4963.44 | 77591-33-4 |
| Not listed by Condor Research | Thymosin β4 fragment 1–4 (goralatide) | Ac-SDKP | 4 aa | 487.5 | 120081-14-3 |
Physicochemical profile. CAS No. 885340-08-9 · Molecular formula C38H68N10O14 · Molecular weight 889.0 g/mol · Sequence Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (7 aa; thymosin β4 residues 17–23) · Appearance: White lyophilized powder · Solubility: Soluble in water.
Specification & quality. Each bottle contains 60 HPMC (vegan) capsules, each holding 500mcg of TB-500 (Ac-LKKTETQ) at ≥99% (HPLC). The 500mcg figure is an analytical reference quantity (mass per unit), not a dose; the pre-measured solid format serves gravimetric standardisation and reproducible bench handling and is not optimised, intended or suitable for ingestion. Encapsulated — no reconstitution required. Every batch is independently third-party tested, and a Certificate of Analysis (COA) is available. Store at -20°C, protect from light and moisture; shelf life 24 months from the manufacture date. EU warehoused.
This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.
Quantities are analytical reference quantities (mass per unit), not doses, and the capsule format is not intended for ingestion. Working from one quantity in solution instead? See the TB-500 (Frag) 2 mg lyophilised vial. Both formats carry the fragment Ac-LKKTETQ, not the full-length thymosin β4 of the TB-500 10 mg vial. For laboratory research use only. Not for human or veterinary use.
| Parameter | Specification |
|---|---|
| Format | Hard capsule, solid fill, no liquid phase |
| Content per unit | See the product specification above (Content per unit) |
| Shell | HPMC (hypromellose, plant-derived) |
| Excipient or filler | Not stated in the product record |
| Compound | Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (7 residues; thymosin β4 residues 17–23) |
| CAS number / formula | 885340-08-9 / C38H68N10O14 |
| Purity as listed | ≥99% (HPLC) |
| Reconstitution | None; the capsule is a solid format |
| Storage | −20 °C, protected from light and moisture; 24-month shelf life from manufacture |
| Corresponding vial | TB-500 (Frag) lyophilised vial |
Content per unit is a specification of the material, not a recommendation of any use.
A pre-weighed solid unit is characterised differently from a bulk vial. In a vial, the analytical question is the composition of one sealed quantity and the behaviour of the reconstituted solution. In a capsule it is also the variation between units. The compendial methods below are the reference procedures a laboratory can apply to this format; this table describes the methods and does not report results.
| Attribute | Reference method | What it establishes for a capsule | Vial counterpart |
|---|---|---|---|
| Uniformity of content between units | Ph. Eur. 2.9.40 Uniformity of dosage units; USP <905> Uniformity of Dosage Units | Spread of individual unit content around the nominal value, by assay of individual units (content uniformity) or by mass variation | Not applicable; one unit per vial |
| Release of the content into a medium | Ph. Eur. 2.9.3 Dissolution test for solid dosage forms; USP <711> Dissolution | Rate and extent to which the fill enters a defined medium under defined apparatus and agitation; shell opening is part of the measurement | Reconstitution behaviour, which is a solubility observation rather than a release profile |
| Identity and purity of the content | HPLC with UV detection; LC-MS for mass identity | Retention behaviour, peak purity and measured molecular mass of the fill, together with related substances | Same methods apply to the lyophilised cake |
| Water content | Karl Fischer titration (Ph. Eur. 2.5.12 Water: semi-micro determination; USP <921> Water Determination) | Residual water in the fill, which bears on the storage stability of a solid peptide | Same method applies to the lyophilised cake |
| Shell and unit integrity | Visual inspection, unit mass and closure check | Intact, correctly closed units of uniform appearance | Seal and cake appearance |
Method. PubMed was searched on 2026-10-18 for the names and sequence of TB-500 (Ac-LKKTETQ) combined with simulated gastric fluid, simulated intestinal fluid, gastric juice, INFOGEST, in vitro digestion, Caco-2, intestinal permeability and oral administration (title and abstract). Records were classified from the abstract by model and by what was reported. Quantities administered were not extracted. The results describe laboratory and animal models and are not a statement about people.
| Model | Records | What was reported | n |
|---|---|---|---|
| Simulated gastric or intestinal fluid; static or dynamic in vitro digestion (INFOGEST-type) | 0 | No study found | — |
| Caco-2 monolayer or other intestinal permeability model | 0 | No study found | — |
| Animal studies with the oral route stated for Ac-LKKTETQ | 0 | No study found | — |
| Other models: in vitro systems (liver and kidney fractions, serum, enzymes) and rat urine; none gastrointestinal | 3 | TB-500 is cleaved and metabolised in these matrices; Ac-LK and Ac-LKK were quantified in one of them (PMID 38382158). Zvereva et al., 2016, J Proteomics (PMID 27569051); Esposito et al., 2015, J Pept Sci (PMID 25469748); Rahaman et al., 2024, J Chromatogr B Analyt Technol Biomed Life Sci (PMID 38382158) | Not applicable |
| Recombinant human thymosin β4 (a different molecule, 43 residues), oral route in a colitis model | 1 | Different molecule; it does not inform Ac-LKKTETQ. Zhao et al., 2026, Mol Biomed (PMID 42606759) | Not stated in abstract |
Under this query no study reports the stability of Ac-LKKTETQ in simulated gastric or intestinal fluid, in a digestion model, in Caco-2 monolayers or after an oral route in animals. The available in vitro work concerns metabolism in serum, kidney and liver fractions, where the peptide is cleaved and metabolised. That evidence addresses a different compartment from the gut and does not support a conclusion about gastrointestinal stability. The one oral-route study retrieved used the full-length protein, a different molecule.
Reference methods for designing such a study: the INFOGEST static in vitro digestion protocol (Brodkorb et al., 2019, Nat Protoc; PMID 30886367; doi:10.1038/s41596-018-0119-1) and the Caco-2 permeability protocol (Hubatsch et al., 2007, Nat Protoc; PMID 17853866; doi:10.1038/nprot.2007.303). The INFOGEST protocol was developed for food digestion, so its use with a peptide reagent is an adaptation, not a validated standard for this compound.
| Design requirement | Vial (bulk, reconstituted) | Capsule (identical solid units) |
|---|---|---|
| Concentration series or titration in solution | Suited: one quantity is dissolved and diluted to any concentration | Each unit fixes the mass; a series needs several units or a stock prepared from them |
| Cell-culture work needing a sterile stock | Suited: a stock is prepared directly from the vial | Requires the fill to be recovered and dissolved; the shell is a further variable |
| Replicates from identical units | Replicates depend on repeated aliquoting of one solution | Suited: identical units of fixed nominal content |
| Release or digestion models that start from a solid unit | Not representative of a unit format | Suited: the experiment starts from a solid unit with a defined shell |
| Gravimetric standardisation of small quantities | Weighing is repeated by the user | Mass per unit is fixed in advance |
| Stability of the compound as a bulk solid | Lyophilised cake in a sealed vial | Solid in a shell; depends on the shell and closure |
Search date for this block: 2026-10-18. For laboratory research use only. Not for human or veterinary use.
Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.
Certificate of Analysis — lot-specific COA ships with every order and is available on request.
Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.
References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.
Choose the capsules when a protocol needs identical, pre-weighed units, 500 mcg each and 30 mg per bottle, for example in replicate or blinded designs. Choose the separate 2 mg lyophilised vial when the work starts from one quantity reconstituted to a chosen concentration. The molecule is the same in both: Ac-LKKTETQ. For laboratory research use only. Not for human or veterinary use.
TB-500 in this product is the synthetic heptapeptide Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ), residues 17–23 of thymosin β-4 with an acetylated N-terminus — the protein's central actin-binding motif. It is the same molecule as the TB-500 (Frag) vial and differs from Condor's TB-500 10 mg vial, which is full-length 43-residue thymosin β-4. Condor Research supplies it strictly as a Research Use Only reference compound for in vitro and animal studies, not for human or veterinary use.
TB-500 here is a 7-residue thymosin β-4 fragment (Ac-LKKTETQ) studied around the actin-binding motif linked to cell motility and angiogenesis assays, whereas BPC-157 is a 15-residue gastric pentadecapeptide studied around cytoprotection and the nitric-oxide system. They sit in different mechanistic classes and address different research questions about tissue dynamics. Both are supplied strictly as research-use-only reference compounds, not for human or veterinary use.
No. Thymosin β-4 is the full 43-residue protein (4963.44 g/mol) and one of the most abundant actin-binding molecules in many cells, with expression mapped across human organ development (Faa et al., 2024). The TB-500 in these capsules is only residues 17–23 (Ac-LKKTETQ, 889.0 g/mol). Short peptides carrying this motif reproduced some of the parent protein's activity in cell and animal models (Philp et al., 2003), but results for the full protein cannot be assumed for the fragment. Both are handled only as research-use-only reference materials, never for human or veterinary use.
TB-500 is studied around actin regulation, cell migration and angiogenesis, while KPV is a melanocortin-derived tripeptide studied chiefly for anti-inflammatory signalling in intestinal and dermal models. They illuminate different stages of the tissue-response question — structural remodelling versus inflammatory tone. Each is offered solely as a Research Use Only reference compound, not for human or veterinary use.
Yes. Condor Research supplies TB-500 strictly as a Research Use Only reference compound to professionals and institutions, not as a medicine, supplement or product for human or veterinary use. Buyers are responsible for confirming import legality in their own country. Questions: info@condorresearch.com.
The capsule is simply a pre-weighed solid format: 500mcg of TB-500 sealed in an HPMC (vegan) shell so each unit holds a precise, handling-ready quantity. This removes weighing steps at the bench and requires no reconstitution. The format is a laboratory convenience only and does not imply or permit human or veterinary consumption — for research use only.
No. The peptide is already encapsulated as a pre-measured solid, so no reconstitution is required for handling. Researchers prepare working solutions according to their own validated experimental protocols. The capsule is a laboratory format only and is not intended for human or veterinary use.
Each bottle contains 60 HPMC (vegan) capsules, each holding 500mcg of TB-500 (Ac-LKKTETQ) at ≥99% (HPLC) purity. The 500mcg figure is an analytical reference quantity (mass per unit), not a dose. Every batch is independently third-party tested and a Certificate of Analysis is available on request. This specification describes a research reference material, not a product for human or veterinary use.
TB-500 (Ac-LKKTETQ) has CAS No. 885340-08-9, molecular formula C38H68N10O14 and a molecular weight of 889.0 g/mol. It is a 7-amino-acid peptide (thymosin β-4 residues 17–23) with an acetylated N-terminus, supplied as a white lyophilized powder, soluble in water. These values are provided for laboratory characterisation and research use only.
Yes. Every TB-500 batch is tested by an independent third-party laboratory by HPLC for identity and purity (≥99%), and each lot ships with a lot-specific Certificate of Analysis. To request the COA for your batch, contact info@condorresearch.com. This documentation supports research use only, not human or veterinary application.
Store at -20°C, protected from light and moisture, to preserve peptide integrity over the stated 24-month shelf life from the manufacture date. Stock is EU warehoused for reliable regional supply. For laboratory research use only. Not for human or veterinary use.
Condor Research supplies TB-500 Capsules directly, dispatched from our EU facility in Slovakia to the EU, EEA, UK and Switzerland. Deliveries to EU destinations clear no third-country customs, and shipping is calculated at checkout. Supplied strictly as a research-use-only reference material — not for human or veterinary use.
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