Research use only · EU-warehoused · COA on every batch · HPLC ≥99% · Shipment 2–5 days
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Semax

Semax

Lyophilised · ≥99% (HPLC) ·

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Supplied lyophilised. Reconstitution typically uses bacteriostatic water.

How to reconstitute Semax — stock calculator
Independently third-party tested · COA on every batch · 48h EU dispatch
[01]

Overview

Semax is a synthetic heptapeptide analogue of the ACTH(4-10) fragment, proline-modified for enzymatic stability, and a landmark of Russian neuropeptide research studied in neuroprotection, BDNF-signalling and cognition models. CAS 80714-61-0; molecular formula C39H54N10O10S; sequence Met-Glu-His-Phe-Pro-Gly-Pro; supplied lyophilised at ≥99% by HPLC. For laboratory research use only.

Developed from a fragment of a naturally occurring hormone, Semax is a synthetic heptapeptide analogue of the ACTH(4-10) sequence, stabilised by a C-terminal Pro-Gly-Pro extension that resists rapid enzymatic breakdown. It is one of the most studied peptides in the neuropeptide and neuroprotection literature, particularly within Russian and broader experimental research on cognition and brain injury.

A stabilised fragment of ACTH. Semax was engineered by modifying the N-terminal region of the melanocortin ACTH(4-10) fragment and adding a proline-containing tail, a design that confers metabolic stability while retaining centrally active, non-hormonal properties (Glazova et al., 2005). This structural strategy underpins the peptide's enduring use as a research tool for probing melanocortin- and neurotrophin-related signalling.

What the research explores. Across animal and in-vitro systems, Semax has been investigated along several intersecting themes:

  • Neuroprotection & ischemic-brain models — studied for effects on brain gene-expression profiles after experimental cerebral ischemia (Filippenkov et al., 2025; Dergunova et al., 2021).
  • Neurotransmitter & neurotrophic signalling — examined for influence on monoaminergic systems and BDNF-related pathways with reported nootropic properties (Eremin et al., 2005).
  • Copper interaction & amyloid research — explored as a copper-chelating peptide affecting copper-induced amyloid-β aggregation (Sciacca et al., 2022; Tomasello et al., 2025).

The activity described here is drawn from in-vitro and animal studies; it characterises biological behaviour in experimental models and does not establish efficacy or safety in humans. Full citations are listed under the Scientific References tab.

Physicochemical profile. CAS No. 80714-61-0 · Molecular formula C37H51N9O10S · Molecular weight 813.93 g/mol · Sequence Met-Glu-His-Phe-Pro-Gly-Pro · Appearance: white lyophilized powder · Solubility: soluble in water.

Specification & quality. Each individually sealed vial contains 10 mg of Semax as a white lyophilized powder at ≥99% purity by HPLC. Every batch is third-party tested, and a Certificate of Analysis (COA) is available. Store at −20 °C, protected from light and moisture; shelf life 24 months from the manufacture date.

This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.

Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.

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Quality & COA

Certificate of Analysis
Lot-specific COA with every order

Certificate of Analysis — lot-specific COA ships with every order and is available on request.

Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.

HPLC purity
≥99% (HPLC)
Method
HPLC + MS
Endotoxin
Reported
[02]

Data Sheet

CAS number80714-61-0
Molecular formulaC37H51N9O10S
Molecular weight813.93
SequenceMet-Glu-His-Phe-Pro-Gly-Pro
Purity≥99% (HPLC)
Physical formWhite lyophilized powder
Quantity10mg/vial
SolubilitySoluble in water
StorageStore at -20°C, protect from light
ReconstitutionReconstitute with bacteriostatic water or sterile saline.
Shelf life24 months from manufacture date
OriginEU · Slovakia
ClassificationResearch use only
[03]

Scientific References

01 Liapina LA, Pastorova VE, Obergan TIu, Samonina GE, Ashmarin IP, Miasoedov NF. [Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application]. Izv Akad Nauk Ser Biol. 2006(2):193-203. PMID: 16634437. PubMed 02 Eremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005;30(12):1493-500. PMID: 16362768. doi:10.1007/s11064-005-8826-8. PubMed 03 Glazova NIu, Sebentsova EA, Levitskaia NG, Andreeva LA, Alfeeva LIu, Kamenskiĭ AA, et al. [Effect of modification of the N-terminal region of molecule on the expression of neotropic effect of semax analogues]. Izv Akad Nauk Ser Biol. 2005(4):460-6. PMID: 16212268. PubMed 04 Liu R, Chen Y, Huang H, Li X, Lv J, Jiang L, et al. Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. Br J Pharmacol. 2025;182(22):5489-5516. PMID: 40692165. doi:10.1111/bph.70122. PubMed 05 Radchenko AI, Kuzubova EV, Apostol AA, Mitkevich VA, Andreeva LA, Limborska SA, et al. The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease. Acta Naturae. 2025;17(4):110-120. PMID: 41479572. doi:10.32607/actanaturae.27808. PubMed 06 Kolbaev SN, Sharonova IN, Skrebitsky VG. The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons. Bull Exp Biol Med. 2025;179(4):416-420. PMID: 41171324. doi:10.1007/s10517-025-06501-z. PubMed 07 Filippenkov IB, Shpetko YY, Ales DA, Stavchansky VV, Denisova AE, Yuzhakov VV, et al. Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage. Int J Mol Sci. 2025;26(13). PMID: 40650034. doi:10.3390/ijms26136256. PubMed 08 Tomasello MF, Di Rosa MC, Naletova I, Sciacca MFM, Giuffrida A, Maccarrone G, et al. Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing. Bioinorg Chem Appl. 2025;2025:4226220. PMID: 40496623. doi:10.1155/bca/4226220. PubMed 09 Filippenkov IB, Shpetko YY, Stavchansky VV, Denisova AE, Gubsky LV, Andreeva LA, et al. ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke. Biomedicines. 2024;12(12). PMID: 39767736. doi:10.3390/biomedicines12122830. PubMed 10 Inozemtseva LS, Yatsenko KA, Glazova NY, Kamensky AA, Myasoedov NF, Levitskaya NG, et al. Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress. Eur J Pharmacol. 2024;984:177068. PMID: 39442746. doi:10.1016/j.ejphar.2024.177068. PubMed 11 Asadullah A, Bajamal AH, Parenrengi MA, Turchan A, Utomo B, Sudiana IK, et al. Effect of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury models (male Sprague Dawley rats). F1000Res. 2023;12:194. PMID: 41179234. doi:10.12688/f1000research.127413.2. PubMed 12 Azzam M, Fahmi A, Utomo B, Faris M, Parenrengi MA, Sudiana IK, et al. The Effect of ACTH(4-10) PRO8-GLY9-PRO10 Administration on the Expression of IL-6 and IL-8 in Sprague Dawley Mice with Spinal Cord Injury. J Neurosci Rural Pract. 2022;13(3):370-375. PMID: 35946003. doi:10.1055/s-0042-1744468. PubMed 13 Sciacca MFM, Naletova I, Giuffrida ML, Attanasio F. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chem Neurosci. 2022;13(4):486-496. PMID: 35080861. doi:10.1021/acschemneuro.1c00707. PubMed 14 Sudarkina OY, Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, Sevan'kaeva LE, et al. Brain Protein Expression Profile Confirms the Protective Effect of the ACTH((4-7))PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion. Int J Mol Sci. 2021;22(12). PMID: 34201112. doi:10.3390/ijms22126179. PubMed 15 Dergunova LV, Dmitrieva VG, Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, et al. [The Peptide Drug ACTH(4-7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain]. Mol Biol (Mosk). 2021;55(3):402-411. PMID: 34097675. doi:10.31857/S0026898421010043. PubMed

References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.

[05]

FAQ

Semax is a synthetic heptapeptide analogue of the ACTH(4-10) sequence, supplied strictly as a research-use-only reference material. Its sequence (Met-Glu-His-Phe-Pro-Gly-Pro) carries a C-terminal Pro-Gly-Pro extension that resists rapid enzymatic breakdown. Condor Research offers it as a 10 mg lyophilized vial at ≥99% HPLC purity for in-vitro laboratory study only.

Semax and Selank are different synthetic heptapeptides from distinct origins. Semax (Met-Glu-His-Phe-Pro-Gly-Pro) derives from the ACTH(4-10) fragment and is studied as a neuropeptide/nootropic research model. Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derives from the immune peptide tuftsin and is investigated in anxiolytic-focused research. Both are sold as separate ≥99% HPLC, research-use-only reference compounds.

That depends on your experimental design. Separate 10 mg vials of Semax and Selank let you control each compound's concentration independently, while the co-formulated Semax + Selank blend (10 mg + 10 mg) supplies both peptides in one vial. All formats are research-use-only reference materials. For pricing comparison, contact info@condorresearch.com.

Semax is engineered from the ACTH(4-10) fragment of adrenocorticotropic hormone, stabilized by a Pro-Gly-Pro tail; Selank is engineered from tuftsin, an immune-derived tetrapeptide. The two share a heptapeptide length but originate from unrelated parent molecules, which is why they are studied as distinct neuropeptide research tools rather than interchangeable analogues.

Semax is a single, chemically defined synthetic heptapeptide (≥99% HPLC), whereas Cerebrolysin is a defined biological peptide mixture rather than one molecule. Researchers select Semax when a single, sequence-verified reference compound is needed, and Cerebrolysin when a complex peptide preparation is the study subject. Both are supplied as research-use-only materials.

Yes. Semax is supplied strictly for laboratory research use only (in vitro). It is not a medicine, food, supplement, cosmetic, or medical device, and is not for human or veterinary use, administration, or consumption. Condor Research provides no human-use guidance, dosing, or protocols. Purchase is limited to qualified professionals and institutions aged 18 or over.

For analytical laboratory preparation only, Semax is water-soluble and can be reconstituted with a sterile aqueous diluent; the chosen volume sets the working concentration. Store the sealed lyophilized vial at -20°C, protected from light, with a 24-month shelf life from manufacture. This is laboratory handling information, not guidance for any human or animal use.

Yes. Each Semax lot is tested by an independent third-party laboratory by HPLC for identity and purity, with mass spectrometry confirmation, and ships against a batch-specific Certificate of Analysis (COA) verifying ≥99% purity. To request the COA for the current lot before ordering, contact info@condorresearch.com.

Each Semax vial contains 10 mg of lyophilized peptide at ≥99% HPLC purity, supplied as a research-use-only reference material. The stated mass is an analytical reference quantity, not a dose. Vial fill and identity are verified by independent third-party testing and documented on the lot's Certificate of Analysis.

Stability of a reconstituted Semax solution depends on the diluent, temperature, and sterility of your laboratory preparation, so an exact window cannot be guaranteed for every setup. As a reference reagent, the sealed lyophilized vial is most stable stored at -20°C, protected from light. Treat any prepared solution as you would a sensitive research peptide.

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Reviews

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4.7
68 verified reviews
5
78%
4
16%
3
4%
2
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Apr 2026
Impeccable packaging

Cold-chain handling was respected end to end. Vials arrived sealed, labelled and intact. Documentation is the most thorough I've seen from an EU supplier.

Dr. S. Novak · Private lab · CZ Verified purchase
Mar 2026
Reliable, well documented

Solubility and stability were as described. Knocked one star only because express shipping options are limited, but quality is not in question.

P. Andersson · Research institute · SE Verified purchase
Mar 2026
Reproducible across batches

Third order with Condor. Batch-to-batch variation is minimal, which matters for our longitudinal work. The mono-labelled vials are easy to track.

Dr. R. Costa · Academic lab · PT Verified purchase
Feb 2026
Exactly what research needs

No marketing fluff — just characterised material with paperwork. The data sheet and CAS matched our records precisely.

J. Meijer · Biotech R&D · NL Verified purchase

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