Research use only · EU-warehoused · COA on every batch · HPLC ≥99% · Shipment 2–5 days
Log in Register
Home/ Catalogue/ Neuropeptides/ Semax + Selank
In stock
Semax + Selank

Semax + Selank

Lyophilised · ≥99% (HPLC) ·

Quantity Volume discounts auto-applied
Custom quantity
1

Supplied lyophilised. Reconstitution typically uses bacteriostatic water.

Independently third-party tested · COA on every batch · 48h EU dispatch
[01]

Overview

Semax + Selank is a research blend combining two synthetic neuropeptides: Semax (CAS 80714-61-0; heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro, ACTH(4–7)-PGP analogue, proline-stabilised) and Selank (CAS 129954-34-3; heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro, tuftsin analogue). Both are lyophilised at ≥99% purity by HPLC. Each compound has been independently studied in neuroprotection, BDNF signalling, anxiolytic and cognitive models. For laboratory research use only; not for human or veterinary use.

Pairing two of the most studied regulatory neuropeptides to emerge from Russian peptide science, Semax + Selank is a research blend of two short, heptapeptide-class molecules investigated for their effects on the nervous system. Semax is a synthetic analogue of the ACTH(4–10) fragment, while Selank is a synthetic derivative of the immunomodulatory peptide tuftsin — supplied together as a combined preparation for comparative and complementary neuropeptide research.

Two peptides, two regulatory lineages. Semax was developed by modifying the N-terminal region of the adrenocorticotropic hormone fragment ACTH(4–10) and adding a Pro-Gly-Pro tail that confers metabolic stability, yielding a peptide studied for nootropic and neurotrophic-like activity. Selank descends from tuftsin, an endogenous tetrapeptide tied to immune signalling, and is examined largely for anxiolytic-like and neuromodulatory properties. Because the two molecules arise from distinct biological lineages — one neurohormonal, one immunoregulatory — combining them offers researchers a single preparation in which to explore overlapping and divergent peptide actions.

What the research explores. Studies in cellular and animal models have addressed several aspects of the two peptides' biology:

  • Neurochemical modulation — Semax has been characterised as an ACTH(4–10) analogue acting on monoaminergic systems in brain models (Eremin et al., 2005).
  • Enzyme interactions — both peptides have been reported to inhibit enkephalin-degrading enzymes (Kost et al., 2001; Zozulya et al., 2001).
  • Receptor and gene-level effects — work examines Semax engagement with the μ-opioid receptor gene Oprm1 and associated signalling (Liu et al., 2025).
  • Behavioural neuroscience — research investigates Selank, as a tuftsin analogue, in models of morphine-withdrawal-associated behaviour (Konstantinopolsky et al., 2022).

These findings derive from in vitro and animal studies in controlled research settings; they characterise the peptides' biology and do not represent evidence of benefit for any non-investigational application. Full citations are listed under the Scientific References tab.

Physicochemical profile. Appearance: white lyophilized powder · Solubility: soluble in water. (Semax and Selank are distinct heptapeptide-class molecules; see the COA for batch-specific identity data.)

Specification & quality. Each individually sealed vial contains 20 mg of total peptide (Semax 10 mg + Selank 10 mg) as a white lyophilized powder, verified at ≥99% purity by HPLC. Every batch is third-party tested, and a Certificate of Analysis (COA) is available. Store at −20 °C, protected from light and moisture.

This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.

Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.

[04]

Quality & COA

Certificate of Analysis
Lot-specific COA with every order

Certificate of Analysis — lot-specific COA ships with every order and is available on request.

Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.

HPLC purity
≥99% (HPLC)
Method
HPLC + MS
Endotoxin
Reported
[02]

Data Sheet

Purity≥99% (HPLC)
Physical formWhite lyophilized powder
Quantity20mg/vial (Semax 10mg + Selank 10mg)
SolubilitySoluble in water
StorageStore at -20°C, protect from light
Shelf life24 months from manufacture date
OriginEU · Slovakia
ClassificationResearch use only
[03]

Scientific References

01 Liapina LA, Pastorova VE, Obergan TIu, Samonina GE, Ashmarin IP, Miasoedov NF. [Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application]. Izv Akad Nauk Ser Biol. 2006(2):193-203. PMID: 16634437. PubMed 02 Eremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005;30(12):1493-500. PMID: 16362768. doi:10.1007/s11064-005-8826-8. PubMed 03 Glazova NIu, Sebentsova EA, Levitskaia NG, Andreeva LA, Alfeeva LIu, Kamenskiĭ AA, et al. [Effect of modification of the N-terminal region of molecule on the expression of neotropic effect of semax analogues]. Izv Akad Nauk Ser Biol. 2005(4):460-6. PMID: 16212268. PubMed 04 Liu R, Chen Y, Huang H, Li X, Lv J, Jiang L, et al. Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. Br J Pharmacol. 2025;182(22):5489-5516. PMID: 40692165. doi:10.1111/bph.70122. PubMed 05 Radchenko AI, Kuzubova EV, Apostol AA, Mitkevich VA, Andreeva LA, Limborska SA, et al. The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease. Acta Naturae. 2025;17(4):110-120. PMID: 41479572. doi:10.32607/actanaturae.27808. PubMed 06 Kolbaev SN, Sharonova IN, Skrebitsky VG. The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons. Bull Exp Biol Med. 2025;179(4):416-420. PMID: 41171324. doi:10.1007/s10517-025-06501-z. PubMed 07 Filippenkov IB, Shpetko YY, Ales DA, Stavchansky VV, Denisova AE, Yuzhakov VV, et al. Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage. Int J Mol Sci. 2025;26(13). PMID: 40650034. doi:10.3390/ijms26136256. PubMed 08 Tomasello MF, Di Rosa MC, Naletova I, Sciacca MFM, Giuffrida A, Maccarrone G, et al. Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing. Bioinorg Chem Appl. 2025;2025:4226220. PMID: 40496623. doi:10.1155/bca/4226220. PubMed 09 Kost NV, Sokolov OIu, Gabaeva MV, Grivennikov IA, Andreeva LA, Miasoedov NF et al. [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]]. Bioorganicheskaia khimiia. 2001;27(3):180-3. PMID: 11443939. doi:10.1023/a:1011373002885. PubMed 10 Zozulya AA, Kost NV, Yu Sokolov O, Gabaeva MV, Grivennikov IA, Andreeva LN et al. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Bulletin of experimental biology and medicine. 2001;131(4):315-7. PMID: 11550013. doi:10.1023/a:1017979514274. PubMed 11 Konstantinopolsky MA, Chernyakova IV, Kolik LG Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. Bulletin of experimental biology and medicine. 2022;173(6):730-733. PMID: 36322304. doi:10.1007/s10517-022-05624-x. PubMed 12 Doyno CR, White CM Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank. Journal of clinical pharmacology. 2021;61 Suppl 2:S114-S128. PMID: 34396551. doi:10.1002/jcph.1922. PubMed 13 Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA, Aleksandrovna BO, Fedorovich MN, Aleksandrovna AL The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress. Current reviews in clinical and experimental pharmacology. 2021;16(2):162-167. PMID: 32621722. doi:10.2174/1574884715666200704152810. PubMed 14 Mukhina AY, Mishina ES, Bobyntsev II, Medvedeva OA, Svishcheva MV, Kalutskii PV et al. Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank. Bulletin of experimental biology and medicine. 2020;169(2):281-285. PMID: 32651826. doi:10.1007/s10517-020-04868-9. PubMed

References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.

[05]

FAQ

Semax + Selank is a research blend co-formulating two short regulatory neuropeptides — Semax and Selank — in a single vial (10 mg of each, 20 mg total). Both are heptapeptide-class molecules studied for effects on the nervous system. The blend is supplied strictly for laboratory research use only (in vitro) and is not for human or veterinary use, administration or consumption.

Both Semax and Selank are short, stabilised regulatory neuropeptides from the same area of peptide science, and co-formulating them lets researchers study the two together in one preparation. The pairing reflects their shared neuropeptide class, not any consumer rationale. The blend is supplied strictly for laboratory research use only (in vitro), with no human or veterinary application and no dosing guidance.

The blend supplies both peptides co-formulated in one vial (10 mg each), whereas buying them separately gives two standalone vials you reconstitute independently. The blend is convenient for studying them together; separate vials let you control each peptide's preparation independently. All are supplied as synthetic peptides for laboratory research use only (in vitro), not for human or veterinary use.

In total peptide content the blend holds 10 mg of Semax plus 10 mg of Selank, matching the amounts in the standalone vials, but it is a single co-formulated vial reconstituted together rather than two separate vials. The practical difference is preparation, not the listed amounts. The blend is supplied strictly for laboratory research use only (in vitro).

Semax + Selank is a blend of two specific, individually defined neuropeptides, while Cerebrolysin is a single defined mixture of many short peptides and amino acids. One combines two known molecules; the other is an inherently multi-component preparation. Both are studied in neuro research and supplied strictly for laboratory research use only (in vitro), not for human or veterinary use.

For blends, the ≥99% HPLC purity criterion applies per component: each peptide is tested individually, with identity by mass spectrometry and purity by HPLC, and results are documented in the per-batch Certificate of Analysis. Manufacturer documentation is not published, to protect supply-chain integrity. To request the COA, contact info@condorresearch.com. Supplied for laboratory research use only.

Each component is tested individually by an independent third-party laboratory, and the per-batch Certificate of Analysis documents identity and ≥99% HPLC purity for each peptide in the 10 mg + 10 mg formulation. For confirmation of the stated amounts on a specific lot, contact info@condorresearch.com. The blend is supplied strictly for laboratory research use only (in vitro).

The blend is listed as soluble in water, so both peptides are reconstituted together with a single aqueous diluent for analytical laboratory preparation; the vial holds 20 mg total (10 mg + 10 mg). Each component's concentration is derived from its mass and the diluent volume. Any reconstitution data is for in-vitro laboratory use only, never for human or animal use.

Yes. Both Semax and Selank are water-soluble, and the blend is listed as soluble in water, so a single aqueous diluent reconstitutes both components together. This makes one diluent sufficient for the co-formulated vial in laboratory preparation. Any reconstitution data is for analytical laboratory use only, not for human or veterinary use. For details, contact info@condorresearch.com.

Store the unopened vial at -20°C, protected from light (24-month shelf life). After reconstitution, handle the solution as a laboratory working stock kept cold. All storage and preparation guidance is for analytical laboratory use only, never for human or veterinary use, administration or consumption. For batch-specific stability details, contact info@condorresearch.com.

[06]

Reviews

Leave a review
Earn 250 points for a verified review (account required).
4.7
33 verified reviews
5
79%
4
15%
3
3%
2
0%
1
3%
Apr 2026
Trustworthy supplier

Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.

K. Wójcik · Research group · PL Verified purchase
Mar 2026
Reference-grade consistency

Reconstitution was clean with no visible particulates. The lot-specific COA matched the assay we ran in-house — purity is exactly as stated.

Dr. M. Hartmann · Research lab · DE Verified purchase
Mar 2026
COA matched our own HPLC

We verify every incoming compound by HPLC; this batch came back within tolerance of the certificate. Dispatch from the EU warehouse was quick.

L. Fischer · University group · AT Verified purchase
Feb 2026
Impeccable packaging

Cold-chain handling was respected end to end. Vials arrived sealed, labelled and intact. Documentation is the most thorough I've seen from an EU supplier.

Dr. S. Novak · Private lab · CZ Verified purchase
Jan 2026
Reliable, well documented

Solubility and stability were as described. Knocked one star only because express shipping options are limited, but quality is not in question.

P. Andersson · Research institute · SE Verified purchase

Related compounds