Research use only · EU-warehoused · COA on every batch · HPLC ≥99% · Shipment 2–5 days
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DSIP

DSIP

Lyophilised · ≥99% (HPLC) ·

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Supplied lyophilised. Reconstitution typically uses bacteriostatic water.

How to reconstitute DSIP — stock calculator
Independently third-party tested · COA on every batch · 48h EU dispatch
[01]

Overview

DSIP (Delta Sleep-Inducing Peptide) is a synthetic nonapeptide originally isolated from rabbit brain venous blood, studied in sleep-cycle modulation, stress-response attenuation, and neuroendocrine signalling models. Sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu; CAS 62568-57-4; molecular weight 848.8 g/mol; supplied lyophilised at ≥99% purity by HPLC. For laboratory research use only; not for human or veterinary use.

First isolated in the 1970s from the cerebral venous blood of sleeping rabbits, DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide whose biology has fascinated — and puzzled — neuroscientists for half a century. Despite its evocative name, its precise mechanism remains incompletely understood, which is exactly what makes it an enduring subject of experimental investigation into sleep, stress and neuroprotection.

A peptide named for a riddle it has yet to fully explain. DSIP was identified through its apparent ability to promote delta-wave (slow-wave) electroencephalographic activity in animal models. In the decades since, researchers have repeatedly returned to it as an open question in neurochemistry, with one influential review aptly describing it as a "still unresolved riddle" (Kovalzon et al., 2006). Its small, well-defined sequence makes it a tractable probe for dissecting endogenous regulatory peptide signalling.

What the research explores. The literature on DSIP spans several neuroscience and biochemistry themes, all within cellular and animal systems:

  • Sleep and neurochemistry — foundational reviews have surveyed its proposed role in slow-wave activity and the questions that remain about its action (Kovalzon et al., 2006).
  • Anticonvulsant signalling — it has been studied alongside neuropeptide Y as a candidate endogenous anticonvulsant in experimental models (Stanojlović et al., 2008).
  • Antioxidant gene regulation — work has examined its effect on the expression of antioxidant enzyme genes in animal tissue (Kutilin et al., 2014).
  • Memory and neuroprotection — a phosphorylated DSIP variant has been investigated for spatial-memory and p-CREB endpoints in rodent models (Roy et al., 2018).

These observations are drawn entirely from in‑vitro and animal research and provide no basis for conclusions in humans. Full citations are listed under the Scientific References tab.

Physicochemical profile. CAS 62568-57-4 · Molecular formula C35H48N10O15 · Molecular weight 848.82 g/mol · Sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu · Appearance white lyophilized powder · Soluble in water.

Specification & quality. Each individually sealed vial contains 10 mg of DSIP at ≥99% purity by HPLC. Every batch is third-party tested, with a Certificate of Analysis (COA) available. Store at −20 °C, protected from light and moisture.

This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.

Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.

[04]

Quality & COA

Certificate of Analysis
Lot-specific COA with every order

Certificate of Analysis — lot-specific COA ships with every order and is available on request.

Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.

HPLC purity
≥99% (HPLC)
Method
HPLC + MS
Endotoxin
Reported
[02]

Data Sheet

CAS number62568-57-4
Molecular formulaC35H48N10O15
Molecular weight848.82
SequenceTrp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Purity≥99% (HPLC)
Physical formWhite lyophilized powder
Quantity10mg/vial
SolubilitySoluble in water
StorageStore at -20°C, protect from light
ReconstitutionReconstitute with bacteriostatic water or sterile saline.
Shelf life24 months from manufacture date
OriginEU · Slovakia
ClassificationResearch use only
[03]

Scientific References

01 Gimble JM, Ptitsyn AA, Goh BC, Hebert T, Yu G, Wu X et al. Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper: potential links between circadian mechanisms and obesity?. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2009;10 Suppl 2:46-51. PMID: 19849801. doi:10.1111/j.1467-789X.2009.00661.x. PubMed 02 Stanojlović O, Hrncić D, Radosavljević T [Endogenous anticonvulsants: neuropeptide Y and delta sleep inducing peptide]. Medicinski pregled. 2008;61(5-6):252-5. PMID: 19102071. doi:10.2298/mpns0806252s. PubMed 03 Kovalzon VM, Strekalova TV Delta sleep-inducing peptide (DSIP): a still unresolved riddle. Journal of neurochemistry. 2006;97(2):303-9. PMID: 16539679. doi:10.1111/j.1471-4159.2006.03693.x. PubMed 04 Pollard BJ, Pomfrett CJ Delta sleep-inducing peptide. European journal of anaesthesiology. 2001;18(7):419-22. PMID: 11437870. doi:10.1046/j.1365-2346.2001.00917.x. PubMed 05 Shandra AA, Godlevskiĭ LS, Vast'ianov RS, Zaporozhchenko MB, Ibragim M, Brusentsov AI et al. [A rotational syndrome induced by administration of the delta sleep-inducing peptide into the reticular portion of the rat substantia nigra]. Fiziologicheskii zhurnal imeni I.M. Sechenova. 1996;82(10-11):69-72. PMID: 9162398. PubMed 06 Nekrasov AN, Mikhaleva II Cyclo(-GLY-DSIP), A cyclic analog of the delta-sleep-inducing peptide: computer simulation of spatial structure involving NMR data. Biochemistry and molecular biology international. 1996;38(4):739-45. PMID: 8728103. PubMed 07 Mu X, Qu L, Yin L, Wang L, Liu X, Liu D Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models. Frontiers in pharmacology. 2024;15:1439536. PMID: 39444618. doi:10.3389/fphar.2024.1439536. PubMed 08 Karlo J, Vijay A, Phaneeswar MS, Singh SP Sensing the Bactericidal and Bacteriostatic Antimicrobial Mode of Action Using Raman Deuterium Stable Isotope Probing (DSIP) in Escherichia coli. ACS omega. 2024;9(22):23753-23760. PMID: 38854576. doi:10.1021/acsomega.4c01666. PubMed 09 Tukhovskaya EA, Ismailova AM, Shaykhutdinova ER, Slashcheva GA, Prudchenko IA, Mikhaleva II et al. Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke. Molecules (Basel, Switzerland). 2021;26(17). PMID: 34500605. doi:10.3390/molecules26175173. PubMed 10 Tukhovskaya EA, Shaykhutdinova ER, Ismailova AM, Slashcheva GA, Prudchenko IA, Mikhaleva II et al. DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion. Biomedicines. 2021;9(4). PMID: 33918965. doi:10.3390/biomedicines9040407. PubMed 11 Roy K, Chauhan G, Kumari P, Wadhwa M, Alam S, Ray K et al. Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude. Life sciences. 2018;209:282-290. PMID: 30107169. doi:10.1016/j.lfs.2018.08.026. PubMed 12 Zhang XG, Wang WN, Zhang CS, Li K, Ma GD, Li JY Expression and Purification of Delta Sleep-Inducing Peptide Fused with Protein Transduction Domain and Human Serum Albumin in Pichia pastoris. Protein and peptide letters. 2017;24(7):668-675. PMID: 28462721. doi:10.2174/0929866524666170426113022. PubMed 13 Bobyntsev II, Kryukov AA, Belykh AE, Dudka VT Effect of Delta Sleep-Inducing Peptide on Functional State of Hepatocytes in Rats During Restraint Stress. Bulletin of experimental biology and medicine. 2016;160(4):421-4. PMID: 26902351. doi:10.1007/s10517-016-3186-8. PubMed 14 Belykh AE, Bobyntsev II, Kryukov AA, Dudka VT [THE INFLUENCE OF DELTA SLEEP-INDUCING PEPTIDE ON FUNCTIONAL STATE OF RATS HEPATOCYTES IN FOOT-SHOCK STRESS]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2015;101(6):700-7. PMID: 26470489. PubMed 15 Kutilin DS, Bondarenko TI, Kornienko IV, Mikhaleva II Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging. Bulletin of experimental biology and medicine. 2014;157(5):616-9. PMID: 25257425. doi:10.1007/s10517-014-2628-4. PubMed

References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.

[05]

FAQ

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated in the 1970s from the cerebral venous blood of sleeping rabbits. Its sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. Condor Research supplies it as a 10 mg lyophilized vial at ≥99% HPLC purity, strictly as a research-use-only reference material for in-vitro laboratory study.

No. The name reflects the historical research context in which DSIP was first isolated, not a claimed effect or any approved use. DSIP is supplied strictly as a research-use-only reference compound for in-vitro laboratory study; it is not for human or veterinary use, administration, or consumption. Condor Research makes no therapeutic claims and provides no human-use guidance.

DSIP and Selank are different neuropeptides studied in different contexts. DSIP is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) studied in sleep and neuroregulatory research. Selank is a tuftsin-derived heptapeptide investigated in anxiolytic-focused research. Both are supplied as separate 10 mg vials at ≥99% HPLC purity, for research use only.

DSIP and Epitalon are distinct peptides sometimes grouped under sleep/circadian biology. DSIP is a nine-residue naturally occurring peptide studied in sleep-related neuroregulatory research. Epitalon is the tetrapeptide Ala-Glu-Asp-Gly (AEDG), studied as a reagent in cellular-aging research. They differ in sequence, length, and research focus, and each is a separate ≥99% HPLC, research-use-only reference peptide.

DSIP and Semax are different research neuropeptides. DSIP is a naturally occurring nonapeptide studied in sleep and neuroregulatory research. Semax is a synthetic ACTH(4-10)-derived heptapeptide studied as a nootropic research model. Their sequences, origins, and research applications differ, and each is supplied as a separate 10 mg vial at ≥99% HPLC purity for research use only.

Both are short peptides studied in neuro and circadian-adjacent research, but they differ chemically. DSIP is the naturally occurring nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. Pinealon is the synthetic tripeptide Glu-Asp-Arg, framed around neuroprotective research. Each is a distinct ≥99% HPLC, research-use-only reference peptide, selected according to the in-vitro model under study.

Yes. DSIP is supplied strictly for laboratory research use only (in vitro). It is not a medicine, food, supplement, cosmetic, or medical device, and is not for human or veterinary use, administration, or consumption. Condor Research provides no dosing or protocols. Purchase is restricted to qualified professionals and institutions aged 18 or over.

For analytical laboratory preparation only, DSIP is water-soluble and can be reconstituted with a sterile aqueous diluent; the volume chosen sets the working concentration. Store the sealed lyophilized vial at -20°C, protected from light, with a 24-month shelf life from manufacture. This is laboratory handling information, not guidance for any human or animal use.

Yes. Each DSIP lot is tested by an independent third-party laboratory by HPLC for identity and purity, with mass spectrometry confirmation, and ships against a batch-specific Certificate of Analysis (COA) verifying ≥99% purity. To request the COA for the current lot before ordering, contact info@condorresearch.com.

Each DSIP vial contains 10 mg of lyophilized peptide at ≥99% HPLC purity, supplied as a research-use-only reference material. The stated mass is an analytical reference quantity, not a dose. Vial fill and identity are verified by independent third-party testing and documented on the lot's Certificate of Analysis.

[06]

Reviews

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4.7
36 verified reviews
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Apr 2026
High purity, clear labelling

Lyophilised cake was uniform and dissolved fully. Would appreciate a digital COA portal, but the PDF on request worked fine.

Dr. A. Bianchi · University · IT Verified purchase
Mar 2026
Trustworthy supplier

Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.

K. Wójcik · Research group · PL Verified purchase
Mar 2026
Reference-grade consistency

Reconstitution was clean with no visible particulates. The lot-specific COA matched the assay we ran in-house — purity is exactly as stated.

Dr. M. Hartmann · Research lab · DE Verified purchase
Feb 2026
COA matched our own HPLC

We verify every incoming compound by HPLC; this batch came back within tolerance of the certificate. Dispatch from the EU warehouse was quick.

L. Fischer · University group · AT Verified purchase

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