Research use only · EU-warehoused · COA on every batch · HPLC ≥99% · Shipment 2–5 days
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Kisspeptin-10

Kisspeptin-10

Lyophilised · ≥99% (HPLC) ·

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Custom quantity
1

Supplied lyophilised. Reconstitution typically uses bacteriostatic water.

Independently third-party tested · COA on every batch · 48h EU dispatch
[01]

Overview

Kisspeptin-10 is a synthetic decapeptide corresponding to the C-terminal 10-amino-acid fragment of kisspeptin-54 (metastin), encoded by the KISS1 gene and recognised as the endogenous high-affinity ligand for the GPR54/KISS1R receptor. Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2; CAS 374675-21-5; molecular formula C63H83N17O14; molecular weight 1302.4 g/mol; supplied lyophilised at HPLC ≥99% purity. For laboratory research use only; not for human or veterinary use.

Acting at the very top of the reproductive hormone cascade, Kisspeptin-10 is a synthetic 10-amino-acid peptide — the shortest fully active fragment of the kisspeptin family encoded by the KISS1 gene. As a master upstream signal of the hypothalamic-pituitary-gonadal axis, it has become a pivotal molecule in neuroendocrine research and, increasingly, a probe of vascular and inflammatory biology.

The spark at the start of a cascade. Kisspeptins are the endogenous ligands of the KISS1R receptor and sit upstream of gonadotropin-releasing hormone (GnRH), effectively gating the body's reproductive signalling. Kisspeptin-10 reproduces this activity in a compact, readily synthesised form, which has made it the standard experimental tool for interrogating KISS1R-mediated pathways in both reproductive and non-reproductive tissues.

What the research explores. Beyond its founding role in reproductive neuroendocrinology, the peptide spans a widening range of models:

  • Metabolic regulation — examined in obesity-diabetes models for effects on enteroendocrine cells (Sridhar et al., 2025).
  • Vascular biology — studied for effects on pulmonary arterial hypertension via mitochondrial-function pathways (Huang et al., 2026).
  • Neuroinflammation — investigated for modulation of the NLRP3 inflammasome (Kalkan et al., 2026).
  • Cellular senescence — assessed for protective effects on chondrocytes via SIRT1/p53/p21 signalling (Qiu et al., 2025).

These findings derive exclusively from in vitro and animal research; no conclusions regarding human use are supported. Full citations are listed under the Scientific References tab.

Physicochemical profile. CAS 374675-21-5 · Molecular formula C₆₃H₈₃N₁₇O₁₄ · Molecular weight 1302.4 · Sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ · Appearance: white lyophilized powder · Solubility: soluble in water.

Specification & quality. Each individually sealed vial contains 10 mg of Kisspeptin-10 as a white lyophilized powder of ≥99% purity by HPLC. Every batch is third-party tested, with a Certificate of Analysis (COA) available. Store at −20 °C, protected from light and moisture. Shelf life: 24 months from the manufacture date.

This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.

Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.

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Quality & COA

Certificate of Analysis
Lot-specific COA with every order

Certificate of Analysis — lot-specific COA ships with every order and is available on request.

Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.

HPLC purity
≥99% (HPLC)
Method
HPLC + MS
Endotoxin
Reported
[02]

Data Sheet

CAS number374675-21-5
Molecular formulaC₆₃H₈₃N₁₇O₁₄
Molecular weight1302.4
SequenceTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
Purity≥99% (HPLC)
Physical formWhite lyophilized powder
Quantity10mg/vial
SolubilitySoluble in water
StorageStore at -20°C, protect from light
Shelf life24 months from manufacture date
OriginEU · Slovakia
ClassificationResearch use only
[03]

Scientific References

01 Huang S, Chen Z, Gong W et al.. Kisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmonary artery smooth muscle cells. Neuropeptides. 2026. PMID: 41955717. doi:10.1016/j.npep.2026.102611. PubMed 02 Radwańska P, Olkiewicz M, Piera L et al.. Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures. Pharmacol Rep. 2026. PMID: 42159865. doi:10.1007/s43440-026-00870-6. PubMed 03 Suocheng W, Linglong X, Jingshuang G et al.. Kisspeptin-10 Promotes Hormone Secretion, Ovarian Follicles Development and Fecundity via PI3K/AKT/ERK Signal Pathway in Mice. Mol Reprod Dev. 2026. PMID: 41952615. doi:10.1002/mrd.70093. PubMed 04 Shah H, Mohan AM, Shah R et al.. Integrated transcriptomics and miRNA-mRNA network analysis reveals Kisspeptin-10 mediated regulation of EMT and apoptosis in glioblastoma. Comput Biol Chem. 2026. PMID: 41389577. doi:10.1016/j.compbiolchem.2025.108826. PubMed 05 Szysiak N, Kosior-Korzecka U, Greguła-Kania M et al.. Relationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes. J Vet Res. 2026. PMID: 41953732. doi:10.2478/jvetres-2026-0010. PubMed 06 Kalkan ÖF, Erdem Ş, Erdem M et al.. Dual role of Kisspeptin-10 in modulating neuroinflammation: Downregulation of NLRP3 inflammasome activation and Caspase-1-mediated pyroptosis, and activation of BAG3-dependent aggrephagy in microglial cells. Neuropeptides. 2026. PMID: 41380532. doi:10.1016/j.npep.2025.102580. PubMed 07 Sridhar A, Khan D, Muthukumar R et al.. Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice. Biomolecules. 2025. PMID: 41301510. doi:10.3390/biom15111591. PubMed 08 Li L, Guo Y, Zhao K. Kisspeptin-10 Preserves the Blood-Brain Barrier's Integrity Post-Stroke by Augmenting Claudin-10 Expression. Clin Exp Pharmacol Physiol. 2025. PMID: 41022671. doi:10.1111/1440-1681.70079. PubMed 09 Shah H, Mohan AM, Buch L et al.. Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer. Sci Rep. 2025. PMID: 41062590. doi:10.1038/s41598-025-19140-1. PubMed 10 Li J, Chen J, Lu L et al.. Kisspeptin-10 Improves Gestational Diabetes Mellitus Symptoms in Rats by Suppressing Insulin Resistance in Placental Trophoblast Cells by Activating the Cyclic AMP/Protein Kinase A Pathway. Chem Biol Drug Des. 2025. PMID: 40944385. doi:10.1111/cbdd.70169. PubMed 11 Cheng C, Xiong D, Zheng F et al.. Kisspeptin-10 protects against HIV-1 Tat-induced blood-brain barrier dysfunction and neuroinflammation via RhoA/ROCK pathway: Implications for HAND therapy. Neurotoxicology. 2025. PMID: 40712838. doi:10.1016/j.neuro.2025.07.008. PubMed 12 Szysiak N, Kosior-Korzecka U, Greguła-Kania M et al.. Effect of neurokinin B and dynorphin A on kisspeptin-10 secretion from the anterior pituitary cells of pubescent ewes in vitro. J Vet Res. 2025. PMID: 40552024. doi:10.2478/jvetres-2025-0026. PubMed 13 Qiu J, Chen G, Peng G et al.. Kisspeptin-10 Protects Against TNF-α-Induced Chondrocyte Senescence via the SIRT1/p53/p21 Signaling. J Biochem Mol Toxicol. 2025. PMID: 40400312. doi:10.1002/jbt.70298. PubMed 14 Yu H, Xie M, Liufu X et al.. Kisspeptin-10 Prevents the Development of Cerebral Aneurysms by Reducing the Expression of Egr-1. CNS Neurosci Ther. 2025. PMID: 40384564. doi:10.1111/cns.70413. PubMed 15 Szysiak N, Kosior-Korzecka U, Longo V et al.. Influence of neurokinin B, dynorphin A and kisspeptin-10 on in vitro gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes. J Vet Res. 2025. PMID: 40144066. doi:10.2478/jvetres-2025-0003. PubMed

References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.

[05]

FAQ

Kisspeptin-10 is a synthetic 10-amino-acid peptide (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2), the shortest fully active fragment of the kisspeptin family encoded by the KISS1 gene. It acts at the top of the reproductive hormone cascade in research models. Condor Research supplies it as a 10 mg lyophilized vial at ≥99% HPLC purity, strictly for in-vitro laboratory research.

They act on entirely different receptor systems. Kisspeptin-10 (KISS1-derived decapeptide) signals through the KISS1R/GPR54 receptor at the apex of the gonadotropin axis, while PT-141 (Bremelanotide) is a melanocortin-receptor agonist derived from α-MSH. Both touch reproductive biology in research models but via separate pathways. Each is supplied as a distinct ≥99% HPLC, research-use-only reference compound.

Kisspeptin-10 is a KISS1-gene decapeptide studied at the gonadotropin-releasing axis, whereas Selank is a tuftsin-derived heptapeptide investigated in anxiolytic and immune-modulation research. They share only their short length; their sequences, origins, and research targets are unrelated. Condor Research offers both as separate 10 mg vials at ≥99% HPLC purity for laboratory use only.

Kisspeptin-10 is the active decapeptide fragment of the KISS1 gene product, studied in reproductive-axis signalling research. Semax is a synthetic ACTH(4-10) heptapeptide analogue studied as a nootropic/neuroprotective model. The two address different research questions through unrelated receptor systems and are sold as separate ≥99% HPLC, research-use-only reference materials, each with its own batch COA.

Kisspeptin-10 is selected when the research target is the kisspeptin/KISS1R system at the top of the reproductive hormone cascade — a role no other peptide in the catalog occupies. Neuropeptides such as Semax, Selank, or DSIP address cognition, anxiety, or sleep models instead. The choice depends entirely on your in-vitro research question, not on any human application.

For exact salt form, contact info@condorresearch.com, as it can vary by lot. The C-terminal amidated sequence (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2, CAS 374675-21-5) is confirmed for each batch by an independent third-party laboratory using HPLC for purity and mass spectrometry for identity. Results appear on the lot-specific Certificate of Analysis.

Yes. Kisspeptin-10 is supplied strictly for laboratory research use only (in vitro). It is not a medicine, food, supplement, cosmetic, or medical device, and is not for human or veterinary use, administration, or consumption. Condor Research provides no dosing, protocols, or human-use guidance. Purchase is limited to qualified professionals and institutions aged 18 or over.

Yes. Every Kisspeptin-10 lot is tested by an independent third-party laboratory by HPLC for identity and purity, with mass spectrometry confirmation, and ships against a batch-specific Certificate of Analysis verifying ≥99% purity. To request the COA for the current lot before ordering, contact info@condorresearch.com.

For analytical laboratory preparation only, Kisspeptin-10 is water-soluble and can be reconstituted with a sterile aqueous diluent; the volume you choose sets the working concentration. Store the sealed lyophilized vial at -20°C, protected from light, with a 24-month shelf life from manufacture. This is laboratory handling information, not guidance for any human or animal use.

Stability of a reconstituted Kisspeptin-10 solution depends on the diluent, temperature, and sterility of your laboratory preparation, so no fixed window can be guaranteed for every setup. The sealed lyophilized vial is most stable stored at -20°C, protected from light. Aliquoting to limit freeze-thaw cycles is common practice for sensitive research peptides.

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Reviews

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4.7
22 verified reviews
5
77%
4
18%
3
5%
2
0%
1
0%
Apr 2026
Reference-grade consistency

Reconstitution was clean with no visible particulates. The lot-specific COA matched the assay we ran in-house — purity is exactly as stated.

Dr. M. Hartmann · Research lab · DE Verified purchase
Mar 2026
COA matched our own HPLC

We verify every incoming compound by HPLC; this batch came back within tolerance of the certificate. Dispatch from the EU warehouse was quick.

L. Fischer · University group · AT Verified purchase
Mar 2026
Impeccable packaging

Cold-chain handling was respected end to end. Vials arrived sealed, labelled and intact. Documentation is the most thorough I've seen from an EU supplier.

Dr. S. Novak · Private lab · CZ Verified purchase
Feb 2026
Reliable, well documented

Solubility and stability were as described. Knocked one star only because express shipping options are limited, but quality is not in question.

P. Andersson · Research institute · SE Verified purchase

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