Lyophilised · ≥99% (HPLC) ·
Supplied lyophilised. Reconstitution typically uses bacteriostatic water.
Sermorelin is a synthetic 29-amino-acid peptide corresponding to the biologically active N-terminal fragment of endogenous growth hormone-releasing hormone (GHRH 1-29), the shortest fragment retaining full receptor-binding activity at the GHRH receptor. CAS 86168-78-7; molecular weight 3357.93 g/mol; molecular formula C149H246N44O42S; supplied lyophilised at ≥99% purity by HPLC. Studied extensively in models of somatotroph function, GH secretion, and neuroendocrine signalling. For laboratory research use only; not for human or veterinary use.
Representing the minimal active core of a much larger hormone, Sermorelin is a synthetic 29-amino-acid peptide corresponding to GRF(1-29) — the N-terminal fragment that carries the full biological activity of human growth-hormone-releasing hormone (GHRH). For decades it has served as a foundational reference compound for studying the GHRH receptor and the growth-hormone axis.
The shortest sequence that still speaks the hormone's language. GHRH is a 44-residue peptide, yet researchers found that its first 29 amino acids retain essentially complete potency at the GHRH receptor. This made GRF(1-29) — Sermorelin — an elegant, economical probe of growth-hormone secretion, and a long-standing scaffold for peptide-chemistry research (Argente et al., 1996; Prakash et al., 1999).
What the research explores. The peptide underpins multiple lines of endocrine and chemical investigation:
These findings derive from in vitro, animal, and clinical research and are presented strictly in that investigational frame, with no claim of human benefit. Full citations are listed under the Scientific References tab.
Physicochemical profile. CAS 86168-78-7 · Molecular formula C₁₄₉H₂₄₆N₄₄O₄₂S · Molecular weight 3357.9 · Sequence Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂ · Appearance: white lyophilized powder · Solubility: soluble in water.
Specification & quality. Each individually sealed vial contains 5 mg of Sermorelin as a white lyophilized powder of ≥99% purity by HPLC. Every batch is third-party tested, with a Certificate of Analysis (COA) available. Store at −20 °C, protected from light and moisture. Shelf life: 24 months from the manufacture date.
This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.
Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.
Certificate of Analysis — lot-specific COA ships with every order and is available on request.
Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.
References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.
Sermorelin is a synthetic 29-amino-acid peptide corresponding to GRF(1-29), the N-terminal fragment that carries the full biological activity of human growth-hormone-releasing hormone (GHRH). It represents the minimal active core of the larger hormone. Condor Research supplies it as a 5 mg vial, third-party tested to ≥99% purity by HPLC, strictly for in-vitro research use.
Both are 29-residue GRF(1-29) analogues, but Sermorelin is the bare native sequence, while CJC-1295 no DAC is "Modified" GRF (1-29): it carries amino-acid substitutions (including D-Ala at position 2) that resist enzymatic breakdown, giving greater stability. Sermorelin is the shorter-lived parent sequence; the modified version is engineered for durability. Both are Research Use Only peptides.
Sermorelin is exactly GRF(1-29) — the unaltered 29-residue N-terminal fragment that retains GHRH's full activity. Modified GRF (1-29), the basis of CJC-1295 no DAC, keeps that same length but adds stabilizing substitutions to resist degradation. So Sermorelin is the native template and the modified form its enzyme-resistant counterpart. Both are in-vitro research materials.
Length and stabilization differ. Sermorelin is the minimal 29-residue GRF(1-29) with no added protection. Tesamorelin is a longer 44-residue GHRH analogue stabilized by an N-terminal trans-3-hexenoyl cap, engineered for greater metabolic stability. Both target the GHRH-receptor pathway as research peptides. Each is supplied strictly for in-vitro laboratory use.
Sermorelin is the native GRF(1-29) sequence, cleared rapidly and short-acting. CJC-1295 DAC adds a Drug Affinity Complex that binds serum albumin, greatly extending its half-life in research models. So they sit at opposite ends of the duration spectrum among GHRH analogues. Both are supplied as Research Use Only reference peptides, with no use protocols provided.
They act on different receptors. Sermorelin is a GHRH-receptor analogue (GRF 1-29), while Ipamorelin is a selective ghrelin-receptor (GHS-R) agonist. Because they engage complementary pathways, GHRH analogues and ghrelin-receptor peptides are often studied side by side in growth-hormone-secretagogue research. Both are offered strictly as in-vitro reference materials.
Each lot is tested by an independent third-party laboratory, with identity and purity confirmed by HPLC and mass spec, and ships with a batch-specific Certificate of Analysis certifying ≥99% purity. The listed sequence and molecular weight (3357.9) correspond to native GRF(1-29) Sermorelin. To request the current lot COA, email info@condorresearch.com.
Sermorelin is a water-soluble lyophilized powder, dissolved in a compatible aqueous diluent for in-vitro preparation, with volume chosen to reach the target analytical concentration from the 5 mg vial. Store the sealed vial at -20°C, protected from light (24-month shelf life). This is analytical preparation only; no human or veterinary dosing guidance is provided.
No — Sermorelin is supplied strictly as a Research Use Only (in vitro) reference material: not a medicine, supplement or medical device, and not for human or veterinary administration or consumption. Sales are restricted to professionals and institutions aged 18+. Buyers are responsible for confirming the legality of import in their own jurisdiction.
Third order with Condor. Batch-to-batch variation is minimal, which matters for our longitudinal work. The mono-labelled vials are easy to track.
No marketing fluff — just characterised material with paperwork. The data sheet and CAS matched our records precisely.
Lyophilised cake was uniform and dissolved fully. Would appreciate a digital COA portal, but the PDF on request worked fine.
Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.
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