Lyophilised · ≥99% (HPLC) ·
Supplied lyophilised. Reconstitution typically uses bacteriostatic water.
Growth hormone is released in pulses, and researchers have long sought signals that extend those pulses without erasing their rhythm. CJC-1295 DAC is a synthetic analog of growth hormone-releasing hormone (GHRH) built on the modified GRF(1-29) sequence and fitted with a Drug Affinity Complex (DAC) — a maleimidopropionyl group that binds covalently to circulating serum albumin. This albumin-binding feature is what sets the DAC version apart, dramatically extending its circulating half-life relative to non-DAC GHRH analogs and making it a key tool for studying sustained GH/IGF-1 axis stimulation.
An albumin anchor for a short-lived hormone. Native GHRH is cleared within minutes. By bioconjugating the GRF(1-29) peptide to albumin via the DAC linker, CJC-1295 DAC resists degradation and remains available far longer, the foundational principle demonstrated when hGRF(1-29)-albumin bioconjugates were shown to activate the GRF receptor (Jetté et al., 2005). This long-acting design lets researchers examine prolonged versus pulsatile GHRH signaling.
What the research explores. The literature characterizes the compound's endocrine pharmacology:
These findings derive from animal models, analytical chemistry, and early clinical research describing biological activity; they do not establish human safety or efficacy. Full citations are listed under the Scientific References tab.
Physicochemical profile. CAS 446262-90-4 · Molecular formula C₁₆₅H₂₆₉N₄₇O₄₆ · Molecular weight 3647.2 g/mol · Sequence: modified GRF(1-29) with a Lys-linked maleimidopropionyl Drug Affinity Complex (albumin-binding) · Appearance: white lyophilized powder · Soluble in water.
Specification & quality. Each individually sealed vial contains 10 mg of CJC-1295 DAC as a white lyophilized powder at ≥99% purity by HPLC. Every batch is third-party tested, with a Certificate of Analysis (COA) available. Store at −20 °C, protected from light and moisture.
This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.
Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.
Certificate of Analysis — lot-specific COA ships with every order and is available on request.
Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.
References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.
CJC-1295 DAC is a synthetic long-acting analogue of growth-hormone-releasing factor: the Modified GRF (1-29) sequence joined to a Drug Affinity Complex (DAC), a maleimidopropionyl group that binds circulating albumin to greatly extend its duration in research models. Condor Research supplies it as a 10 mg lyophilized vial at ≥99% HPLC purity, for in-vitro laboratory use only.
The difference is the Drug Affinity Complex. CJC-1295 DAC carries an albumin-binding DAC moiety that markedly extends its half-life, while CJC-1295 no DAC (Modified GRF 1-29) lacks it and is much shorter-acting. The DAC version is also heavier (MW ~3647 vs ~3368). Condor Research offers each as a separate ≥99% HPLC, research-use-only reference compound.
Yes. The DAC version binds albumin to provide sustained, long-acting GHRH-analogue activity in research models, whereas the no-DAC version (Modified GRF 1-29) is short-acting and clears quickly. Researchers studying prolonged signalling pick the DAC form; those needing pulsatile, short-lived exposure choose no-DAC. Both are research-use-only reference compounds, supplied at ≥99% HPLC purity with batch COAs.
The added mass comes from the Drug Affinity Complex — the lysine-linked maleimidopropionyl group that lets CJC-1295 DAC bind albumin. This roughly 280-dalton addition accounts for the higher molecular weight versus CJC-1295 no DAC (Modified GRF 1-29). The acylated mass is confirmed by mass spectrometry on each lot. Both are research-use-only reference materials.
In research models, the albumin-binding DAC gives CJC-1295 DAC a long, sustained profile rather than the short, pulsatile exposure characteristic of CJC-1295 no DAC (Modified GRF 1-29). Researchers studying preserved pulsatility typically favor the no-DAC form. This describes in-vitro research pharmacology only; Condor Research provides no human-use guidance, dosing, or protocols.
CJC-1295 DAC is engineered for a long, sustained profile through albumin binding, whereas Sermorelin is the bare GRF(1-29) fragment with a very short half-life. Both are GHRH analogues, but the DAC moiety makes CJC-1295 DAC far longer-acting in research models. Condor Research supplies each as a separate ≥99% HPLC, research-use-only reference compound.
CJC-1295 DAC achieves its extended duration through an albumin-binding Drug Affinity Complex on a Modified GRF (1-29) backbone, while Tesamorelin is a GRF(1-44) analogue stabilized by an N-terminal hexenoyl cap. Both are studied for prolonged GHRH-analogue activity but via different stabilization strategies. Each is offered as a distinct ≥99% HPLC, research-use-only reference compound.
Yes. The Modified GRF (1-29) sequence with its lysine-linked albumin-binding DAC (CAS 446262-90-4) is verified for each lot by an independent third-party laboratory using HPLC for purity and mass spectrometry for identity and acylated mass. It ships against a batch-specific Certificate of Analysis verifying ≥99% purity, available on request at info@condorresearch.com.
Yes. CJC-1295 DAC is supplied strictly for laboratory research use only (in vitro). It is not a medicine, food, supplement, cosmetic, or medical device, and is not for human or veterinary use, administration, or consumption. Condor Research provides no dosing, protocols, or human-use guidance. Purchase is limited to qualified professionals and institutions aged 18 or over.
For analytical laboratory preparation only, CJC-1295 DAC is water-soluble and can be reconstituted with a sterile aqueous diluent; the chosen volume sets the working concentration. Store the sealed lyophilized vial at -20°C, protected from light, with a 24-month shelf life from manufacture. This is laboratory handling information, not guidance for any human or animal use.
Condor Research supplies CJC-1295 DAC directly, dispatched from our EU facility in Slovakia to the EU, EEA, UK and Switzerland. Deliveries to EU destinations clear no third-country customs, and shipping is calculated at checkout. Supplied strictly as a research-use-only reference material — not for human or veterinary use.
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