Lyophilised · ≥99% (HPLC) ·
Supplied lyophilised. Reconstitution typically uses bacteriostatic water.
CJC-1295 (no DAC) is a synthetic 29-amino-acid analogue of growth hormone-releasing hormone (GHRH), engineered without the Drug Affinity Complex (DAC) to preserve the native pulsatile GH-secretion kinetics studied in neuroendocrine research. CAS 863288-34-0; molecular weight 3367.9 g/mol; supplied lyophilised at ≥99% purity by HPLC. For laboratory research use only; not for human or veterinary use.
Engineered to outlast the body's own rapid clearance of growth-hormone-releasing factor, CJC-1295 (no DAC) — also known as Modified GRF (1-29) — is a synthetic 29-amino-acid analogue of the bioactive N-terminal fragment of human growth-hormone-releasing hormone (GHRH). Critically, it is the variant without the Drug Affinity Complex (DAC), making it the lighter, shorter-acting tetrasubstituted peptide that has become a workhorse in endocrine signalling research.
A fragment refined, not reinvented. Native GRF(1-29) carries the full agonist activity of GHRH but is degraded within minutes, primarily by dipeptidyl peptidase IV (DPP-IV) cleaving its exposed N-terminus (Bai et al., 1995). To counter this, researchers introduced four targeted substitutions — most notably D-Ala at position 2 — yielding a backbone markedly more resistant to enzymatic breakdown while preserving receptor recognition. Unlike its DAC-bearing sibling, this form does not bind albumin, so its activity is comparatively transient.
What the research explores. The molecule has served as a probe for the GHRH receptor and the downstream GH/IGF-1 axis across several lines of inquiry:
These findings derive exclusively from in vitro, animal, and early investigational studies; no conclusions regarding human use are supported. Full citations are listed under the Scientific References tab.
Physicochemical profile. CAS 863288-34-0 · Molecular formula C₁₅₂H₂₅₂N₄₄O₄₂ · Molecular weight 3367.9 · Sequence Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂ · Appearance: white lyophilized powder · Solubility: soluble in water.
Specification & quality. Each individually sealed vial contains 10 mg of CJC-1295 (no DAC) as a white lyophilized powder of ≥99% purity by HPLC. Every batch is third-party tested, with a Certificate of Analysis (COA) available. Store at −20 °C, protected from light and moisture. Shelf life: 24 months from the manufacture date.
This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.
Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.
Certificate of Analysis — lot-specific COA ships with every order and is available on request.
Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.
References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.
CJC-1295 (no DAC), also known as Modified GRF (1-29), is a synthetic 29-amino-acid analogue of the bioactive N-terminal fragment of growth-hormone-releasing hormone (GHRH). The "no DAC" version carries no Drug Affinity Complex, so it does not bind albumin and is shorter-acting. Condor Research supplies it as a 10 mg vial, ≥99% HPLC, for in-vitro research only.
The DAC (Drug Affinity Complex) moiety is the difference. CJC-1295 DAC adds a lysine-linked group that binds serum albumin, greatly extending its circulating half-life. CJC-1295 no DAC (Modified GRF 1-29) omits this group, making it a lighter molecule with no albumin binding and a much shorter duration of action. Both are GHRH-analogue research peptides.
Because the DAC group binds covalently to serum albumin, shielding the peptide from rapid enzymatic clearance, which extends its half-life substantially in research models. CJC-1295 no DAC has no such albumin anchor, so it is cleared quickly and acts over a much shorter window. This contrast is studied as a model of half-life extension in vitro.
Both are 29-residue GHRH N-terminal analogues, but CJC-1295 no DAC is the "modified" GRF(1-29): it carries amino-acid substitutions (including D-Ala at position 2) that resist enzymatic breakdown, giving greater stability than Sermorelin, which is the bare native GRF(1-29) sequence. Both are supplied as Research Use Only peptides.
Both are stabilized GHRH analogues but use different strategies. CJC-1295 no DAC (Modified GRF 1-29) is stabilized by amino-acid substitutions on a 29-residue fragment; Tesamorelin is a longer 44-residue analogue stabilized by an N-terminal trans-3-hexenoyl cap. They are distinct research molecules; both are offered strictly for in-vitro laboratory use.
They act on different receptors. CJC-1295 no DAC (Modified GRF 1-29) is a GHRH-receptor analogue, while Ipamorelin is a selective ghrelin-receptor (GHS-R) agonist. Because they target complementary pathways, they are frequently studied together — and Condor Research offers them co-formulated in the CJC-1295 no DAC + Ipamorelin blend. Both are Research Use Only.
Each lot is tested by an independent third-party laboratory, with identity and purity confirmed by HPLC and mass spec, and ships with a batch-specific Certificate of Analysis certifying ≥99% purity. The listed sequence and molecular weight (3367.9) correspond to the no-DAC Modified GRF (1-29) molecule. Request the current lot COA at info@condorresearch.com.
It is a water-soluble lyophilized powder, dissolved in a compatible aqueous diluent for in-vitro preparation, with volume chosen to reach the target analytical concentration from the 10 mg vial. Store the sealed vial at -20°C, protected from light (24-month shelf life). This is analytical preparation only; no human or veterinary dosing guidance is provided.
No — it is supplied strictly as a Research Use Only (in vitro) reference material: not a medicine, supplement or medical device, and not for human or veterinary administration. Sales are limited to professionals and institutions aged 18+, with a professional-capacity declaration at checkout. Buyers are responsible for confirming the legality of import in their own jurisdiction.
Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.
Reconstitution was clean with no visible particulates. The lot-specific COA matched the assay we ran in-house — purity is exactly as stated.
We verify every incoming compound by HPLC; this batch came back within tolerance of the certificate. Dispatch from the EU warehouse was quick.
Cold-chain handling was respected end to end. Vials arrived sealed, labelled and intact. Documentation is the most thorough I've seen from an EU supplier.
Solubility and stability were as described. Knocked one star only because express shipping options are limited, but quality is not in question.
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