Lyophilised · ≥99% (HPLC) ·
Supplied lyophilised. Reconstitution typically uses bacteriostatic water.
Melanotan II is a synthetic cyclic lactam heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH) and a potent melanocortin agonist studied for its interactions with MC1R, MC3R, MC4R, and MC5R receptors in models of pigmentation, energy homeostasis, and sexual function. CAS 121062-08-6; sequence Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂; molecular weight 1024.2 g/mol; supplied lyophilised at ≥99% purity by HPLC. For laboratory research use only; not for human or veterinary use.
Engineered as a stabilized, cyclized analogue of the body's own α-melanocyte-stimulating hormone (α-MSH), Melanotan II is a synthetic cyclic heptapeptide and a non-selective agonist of the melanocortin receptor family. Its compact ring structure and the substitution of unnatural amino acids make it markedly more resistant to enzymatic breakdown than the native hormone, which is why it has become a recurring tool molecule in melanocortin-system research.
A peptide redesigned from a natural signalling hormone. The melanocortin peptides orchestrate an unusually broad set of physiological signals, from pigmentation to energy balance and central nervous activity. Because the natural α-MSH sequence is rapidly degraded, researchers in the 1980s and 1990s set out to lock its active core into a constrained cyclic scaffold. The result, Melanotan II, retains affinity across several melanocortin receptor subtypes (notably MC1R, MC3R and MC4R), giving experimentalists a single probe with which to interrogate this signalling axis in laboratory models.
What the research explores. Published work using Melanotan II spans several distinct domains, almost all in cellular or animal systems:
These findings derive exclusively from in‑vitro and animal investigations; no human efficacy or safety conclusions should be drawn from them. Full citations are listed under the Scientific References tab.
Physicochemical profile. CAS 121062-08-6 · Molecular formula C50H69N15O9 · Molecular weight 1024.18 g/mol · Sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 · Appearance white lyophilized powder · Soluble in water.
Specification & quality. Each individually sealed vial contains 10 mg of Melanotan II at ≥99% purity by HPLC. Every batch is third-party tested, with a Certificate of Analysis (COA) available. Store at −20 °C, protected from light and moisture.
This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.
Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.
Certificate of Analysis — lot-specific COA ships with every order and is available on request.
Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.
References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.
Melanotan II is a synthetic cyclic heptapeptide and a non-selective agonist of the melanocortin receptor family, engineered as a stabilized, cyclized analogue of α-melanocyte-stimulating hormone (α-MSH). Condor Research supplies it as a 10 mg lyophilized vial at ≥99% HPLC purity, strictly as a research-use-only reference material for in-vitro laboratory study.
Melanotan I (afamelanotide) is a linear tridecapeptide, while Melanotan II is a shorter, cyclized heptapeptide. Melanotan I is more receptor-selective within the melanocortin family, whereas Melanotan II acts non-selectively across multiple melanocortin receptors. Both are supplied as separate ≥99% HPLC, research-use-only reference peptides for melanocortin and pigmentation studies.
Both are cyclic heptapeptides from the same melanocortin family, but they differ at the C-terminus: Melanotan II is the amide (-NH2) form and a broad non-selective melanocortin agonist, while PT-141 (bremelanotide) is the carboxylic-acid (-OH) form and a more focused melanocortin-receptor research analogue. Each is sold as a distinct ≥99% HPLC, research-use-only compound.
The structural difference drives the distinction. Melanotan II's C-terminal amide and cyclic core give it broad agonist activity across the melanocortin receptor subtypes, making it a non-selective research tool. PT-141, the acid-terminated metabolite-derived analogue, engages the family more narrowly. Researchers choose between them based on whether broad or focused melanocortin activity suits the in-vitro model.
Both trace back to α-MSH, but they are very different molecules. Melanotan II is a cyclic heptapeptide acting as a broad melanocortin receptor agonist, studied in pigmentation research. KPV is the short tripeptide (Lys-Pro-Val) from the α-MSH C-terminus, investigated for tissue and immune-related research without the receptor-agonist pigmentation profile. Both are ≥99% HPLC research-use-only reference peptides.
Melanotan II is supplied strictly for laboratory research use only (in vitro) — not a medicine, supplement, or cosmetic, and not for human or veterinary use, administration, or consumption. Import legality varies by country and is the buyer's responsibility to verify; Condor Research screens orders and ships only to permitted destinations. For destination-specific questions, contact info@condorresearch.com.
Condor Research ships from its EU warehouse via Packeta, DPD, and DHL Express across Europe, with truthful research-material customs declarations and tracking. Whether a specific destination is available depends on export screening and local import rules, which the buyer is responsible for verifying. To confirm shipping to your country, contact info@condorresearch.com before ordering.
Yes. Every Melanotan II lot is tested by an independent third-party laboratory using HPLC for identity and purity, with mass spectrometry confirmation, and ships against a batch-specific Certificate of Analysis (COA) documenting ≥99% purity. To receive the COA for the current lot before ordering, contact info@condorresearch.com.
For analytical laboratory preparation only, Melanotan II is water-soluble and can be reconstituted with a sterile aqueous diluent; the volume chosen determines the working concentration. Store the sealed lyophilized vial at -20°C, protected from light, with a 24-month shelf life from manufacture. This is laboratory handling information, not guidance for any human or animal use.
Orders ship in standard neutral outer packaging, with the vial sealed at laboratory grade. Customs paperwork must, by policy, describe the contents truthfully as research material at correct value; Condor Research does not mislabel or undervalue shipments, including on request. For specific packaging questions, contact info@condorresearch.com.
Lyophilised cake was uniform and dissolved fully. Would appreciate a digital COA portal, but the PDF on request worked fine.
Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.
Reconstitution was clean with no visible particulates. The lot-specific COA matched the assay we ran in-house — purity is exactly as stated.
We verify every incoming compound by HPLC; this batch came back within tolerance of the certificate. Dispatch from the EU warehouse was quick.
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