Question 1

What is J-147?

Accepted Answer

J-147 is a curcumin-derived experimental compound from an Alzheimer's drug-discovery program, studied in cell and animal models for neuroprotection, mitochondrial bioenergetics and memory endpoints, with mitochondrial ATP synthase identified as a target (Kepchia et al., 2021). Condor Research supplies it strictly as a Research Use Only reference compound for in vitro and animal studies, not as a medicine or supplement for human or veterinary use.

Question 2

J-147 vs Methylene Blue — both touch mitochondrial biology, how do they differ?

Accepted Answer

Both are studied as mitochondrially active small molecules, but by different mechanisms: J-147 is reported to engage mitochondrial ATP synthase as a target (Kepchia et al., 2021), whereas methylene blue is studied as an electron-cycling redox compound supporting cytochrome-c-oxidase activity. They are therefore used to probe distinct aspects of bioenergetics in research. Both are supplied only as research-use-only reference compounds.

Question 3

J-147 vs curcumin — why move from the natural compound?

Accepted Answer

J-147 was derived from curcumin and refined through phenotypic screening to obtain a distinct, more defined molecule for neurodegeneration research, with its own identified mitochondrial mechanism (Kepchia et al., 2021). Researchers use it when a stable, single-entity reference compound is preferred over a natural polyphenol mixture. Each is offered strictly for laboratory research, never for human or veterinary use.

Question 4

J-147 vs other Alzheimer's drug candidates in research — what is distinctive?

Accepted Answer

Many Alzheimer's candidates target amyloid or tau, whereas J-147 is characterised among geroprotective candidates acting through bioenergetics and the oxytosis/ferroptosis cell-death pathway (Sanchez et al., 2025). This positions it for research questions about cellular energy and oxidative cell death rather than protein aggregation. All such compounds are research-use-only reference materials.

Question 5

What does the research say about J-147 and neuroinflammation?

Accepted Answer

In model systems, J-147 has been examined for modulation of microglial polarisation via CAMKK2/AMPK signalling, framed as an anti-neuroinflammatory mechanism (He et al., 2025). These are findings in experimental systems and do not establish any effect in humans. The compound is supplied for laboratory research use only.

Question 6

Is J-147 legal to buy for research?

Accepted Answer

Yes. Condor Research supplies J-147 strictly as a Research Use Only reference compound to professionals and institutions, not as a medicine, supplement or product for human or veterinary use. Buyers are responsible for confirming import legality in their own country. Questions: info@condorresearch.com.

Question 7

Why is J-147 supplied in capsules for research?

Accepted Answer

The capsule is a pre-weighed solid format that makes a fixed 10mg quantity of J-147 powder easy to store and handle in the laboratory, using HPMC (vegan) shells. It is not a dose for consumption and does not imply ingestion. The capsule format is provided strictly for research use only; not for human or veterinary use.

Question 8

Do these J-147 capsules need reconstitution?

Accepted Answer

No. Each capsule already contains pre-weighed solid J-147 powder, so no reconstitution is required for laboratory handling. For in vitro work, researchers may dissolve the contents in an appropriate solvent such as DMSO. This product is for research use only and not for human or veterinary use.

Question 9

How many capsules per bottle and what is the dose per capsule?

Accepted Answer

Each bottle contains 60 HPMC (vegan) capsules, with each capsule providing 10mg of J-147 at ≥98% (HPLC) purity. Every batch is independently third-party tested. The capsules are a pre-measured solid format for laboratory research use only, not a dose for human or veterinary use.

Question 10

What is the molecular formula and weight of your J-147?

Accepted Answer

J-147 has the molecular formula C18H17F3N2O2, a molecular weight of 350.33 g/mol, and CAS number 1146963-51-0. It presents as an off-white to pale powder, soluble in DMSO. It is supplied strictly as a research-use-only reference compound.

Question 11

Can I see the batch COA confirming J-147 purity?

Accepted Answer

Yes. Every J-147 batch is tested by an independent third-party laboratory by HPLC for identity and purity (≥98%), and ships with a lot-specific Certificate of Analysis. To request the COA for a particular lot, contact info@condorresearch.com. For laboratory research use only. Not for human or veterinary use.

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