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Ipamorelin

Ipamorelin

Lyophilised · ≥99% (HPLC) ·

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Supplied lyophilised. Reconstitution typically uses bacteriostatic water.

How to reconstitute Ipamorelin — stock calculator
Independently third-party tested · COA on every batch · 48h EU dispatch
[01]

Overview

Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) and selective ghrelin receptor (GHS-R1a) agonist studied for its ability to stimulate pulsatile GH release without significantly affecting cortisol, prolactin or ACTH levels in preclinical models. Sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂; CAS 170851-70-4; molecular weight 711.87 g/mol; supplied lyophilised at ≥99% purity by HPLC. For laboratory research use only; not for human or veterinary use.

Introduced as the first of its kind, Ipamorelin is a synthetic pentapeptide that was characterised as the prototype selective growth-hormone secretagogue — a molecule designed to stimulate growth-hormone release through the ghrelin receptor (GHS-R1a) while leaving other pituitary hormones largely untouched. That selectivity has made it one of the most studied reference compounds in growth-hormone-axis research.

The first selective secretagogue. When Ipamorelin was first described, it stood out from earlier growth-hormone-releasing peptides precisely because it raised growth hormone with minimal accompanying release of ACTH or cortisol (Raun et al., 1998). Parallel pharmacokinetic work positioned it among a new generation of peptidyl secretagogues with well-defined profiles (Johansen et al., 1998), and later structural studies used it as the template for designing still more potent hybrids (Hansen et al., 2001).

What the research explores. Across animal, in-vitro, and limited proof-of-concept systems, Ipamorelin has been investigated along several lines:

  • Growth-hormone-axis & skeletal signalling — studied as a selective GH secretagogue and for effects in glucocorticoid-challenged bone models (Raun et al., 1998; Andersen et al., 2001).
  • Gastrointestinal motility — examined as a ghrelin mimetic in rodent post-operative ileus and dysmotility paradigms (Greenwood-Van et al., 2012; Beck et al., 2014).
  • Endocrine & metabolic interactions — explored for its influence on insulin release and the hypothalamic-pituitary axis in animal models (Adeghate et al., 2004; Gouda et al., 2024).

The activity described here is drawn from animal, in-vitro, and early proof-of-concept studies; it characterises biological behaviour in experimental models and does not establish efficacy or safety in humans. Full citations are listed under the Scientific References tab.

Physicochemical profile. CAS No. 170851-70-4 · Molecular formula C38H49N9O5 · Molecular weight 711.85 g/mol · Sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 · Appearance: white lyophilized powder · Solubility: soluble in water.

Specification & quality. Each individually sealed vial contains 10 mg of Ipamorelin as a white lyophilized powder at ≥99% purity by HPLC. Every batch is third-party tested, and a Certificate of Analysis (COA) is available. Store at −20 °C, protected from light and moisture; shelf life 24 months from the manufacture date.

This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.

Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.

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Quality & COA

Certificate of Analysis
Lot-specific COA with every order

Certificate of Analysis — lot-specific COA ships with every order and is available on request.

Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.

HPLC purity
≥99% (HPLC)
Method
HPLC + MS
Endotoxin
Reported
[02]

Data Sheet

CAS number170851-70-4
Molecular formulaC38H49N9O5
Molecular weight711.85
SequenceAib-His-D-2-Nal-D-Phe-Lys-NH2
Purity≥99% (HPLC)
Physical formWhite lyophilized powder
Quantity10mg/vial
SolubilitySoluble in water
StorageStore at -20°C, protect from light
ReconstitutionReconstitute with bacteriostatic water or sterile saline.
Shelf life24 months from manufacture date
OriginEU · Slovakia
ClassificationResearch use only
[03]

Scientific References

01 Johansen PB, Hansen KT, Andersen JV, Johansen NL Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorption. Xenobiotica; the fate of foreign compounds in biological systems. 1998;28(11):1083-92. PMID: 9879640. doi:10.1080/004982598238976. PubMed 02 Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M et al. Ipamorelin, the first selective growth hormone secretagogue. European journal of endocrinology. 1998;139(5):552-61. PMID: 9849822. doi:10.1530/eje.0.1390552. PubMed 03 Lu Z, Ngan MP, Liu JYH, Yang L, Tu L, Chan SW et al. The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism. Physiology & behavior. 2024;284:114644. PMID: 39043357. doi:10.1016/j.physbeh.2024.114644. PubMed 04 Gouda M, Ganesh CB The influence of ghrelin agonist ipamorelin acetate on the hypothalamic-pituitary-testicular axis in a cichlid fish, Oreochromis mossambicus. Animal reproduction science. 2024;268:107550. PMID: 38996787. doi:10.1016/j.anireprosci.2024.107550. PubMed 05 Semenistaya E, Zvereva I, Thomas A, Thevis M, Krotov G, Rodchenkov G Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin. Drug testing and analysis. 2015;7(10):919-25. PMID: 25869809. doi:10.1002/dta.1787. PubMed 06 Beck DE, Sweeney WB, McCarter MD, Ipamorelin 201 Study Group Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. International journal of colorectal disease. 2014;29(12):1527-34. PMID: 25331030. doi:10.1007/s00384-014-2030-8. PubMed 07 Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. Journal of experimental pharmacology. 2012;4:149-55. PMID: 27186127. doi:10.2147/JEP.S35396. PubMed 08 Venkova K, Mann W, Nelson R, Greenwood-Van Meerveld B Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus. The Journal of pharmacology and experimental therapeutics. 2009;329(3):1110-6. PMID: 19289567. doi:10.1124/jpet.108.149211. PubMed 09 Adeghate E, Ponery AS Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats. Neuro endocrinology letters. 2004;25(6):403-6. PMID: 15665799. PubMed 10 Jiménez-Reina L, Cañete R, de la Torre MJ, Bernal G Influence of chronic treatment with the growth hormone secretagogue Ipamorelin, in young female rats: somatotroph response in vitro. Histology and histopathology. 2002;17(3):707-14. PMID: 12168778. doi:10.14670/HH-17.707. PubMed 11 Andersen NB, Malmlöf K, Johansen PB, Andreassen TT, Ørtoft G, Oxlund H The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 2001;11(5):266-72. PMID: 11735244. doi:10.1054/ghir.2001.0239. PubMed 12 Hansen TK, Ankersen M, Raun K, Hansen BS Highly potent growth hormone secretagogues: hybrids of NN703 and ipamorelin. Bioorganic & medicinal chemistry letters. 2001;11(14):1915-8. PMID: 11459660. doi:10.1016/s0960-894x(01)00345-6. PubMed 13 Svensson J, Lall S, Dickson SL, Bengtsson BA, Rømer J, Ahnfelt-Rønne I et al. The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats. The Journal of endocrinology. 2000;165(3):569-77. PMID: 10828840. doi:10.1677/joe.0.1650569. PubMed 14 Gobburu JV, Agersø H, Jusko WJ, Ynddal L Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharmaceutical research. 1999;16(9):1412-6. PMID: 10496658. doi:10.1023/a:1018955126402. PubMed 15 Johansen PB, Nowak J, Skjaerbaek C, Flyvbjerg A, Andreassen TT, Wilken M et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 1999;9(2):106-13. PMID: 10373343. doi:10.1054/ghir.1999.9998. PubMed

References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.

[05]

FAQ

Ipamorelin is a synthetic pentapeptide characterized as the prototype selective growth-hormone secretagogue, acting through the ghrelin receptor (GHS-R). It is widely used in endocrine-signaling research. Condor supplies it strictly as a Research Use Only reference compound for in vitro and animal studies, not for human or veterinary use.

Ipamorelin is a selective ghrelin-receptor (GHS-R) agonist, a pentapeptide that stimulates growth-hormone release through that receptor. CJC-1295 is a GHRH-analogue acting on the GHRH receptor. They engage different receptors and pathways, which is why they are often studied together as complementary secretagogues. Both are supplied for research use only.

Ipamorelin is a selective ghrelin-receptor (GHS-R) agonist, while Sermorelin is a GHRH-analogue corresponding to GRF(1-29) that acts on the GHRH receptor. They stimulate growth-hormone-related signaling through two different receptors, so researchers select them to probe distinct mechanisms or to study together. Both are supplied strictly as research-use-only reference compounds.

Choose standalone Ipamorelin (10 mg) to study the selective ghrelin-receptor agonist in isolation. Choose the CJC-1295 no DAC + Ipamorelin blend (5 mg each) to investigate ghrelin-receptor and GHRH-analogue signaling together in a fixed co-formulated ratio. Both are supplied as Research Use Only reference material for in vitro and animal studies.

Because Ipamorelin (a ghrelin-receptor agonist) and GHRH-analogues like CJC-1295 act on different receptors, combining them lets researchers study two complementary secretagogue pathways at once. Used alone, each isolates a single mechanism. This complementary rationale underlies the CJC-1295 no DAC + Ipamorelin blend. For research use only, in vitro and animal models.

Yes. Condor Research supplies Ipamorelin strictly as a Research Use Only (in vitro) reference compound to professionals and institutions, not as a medicine, supplement or product for human or veterinary use. Buyers are responsible for confirming import legality in their own country. Questions: info@condorresearch.com.

This Ipamorelin has the molecular formula C38H49N9O5 and a molecular weight of 711.85 (CAS 170851-70-4). Its pentapeptide sequence is Aib-His-D-2-Nal-D-Phe-Lys-NH2. Identity and purity (>=99%) are confirmed by HPLC with mass spectrometry on each batch, and the data are documented in the lot-specific Certificate of Analysis.

Yes. Every Ipamorelin batch is tested by an independent third-party laboratory by HPLC for identity and purity (>=99%), with mass spectrometry confirmation, and ships with a lot-specific Certificate of Analysis. To request the COA for a specific lot before ordering, contact info@condorresearch.com.

For laboratory preparation, Ipamorelin is reconstituted in water; for example, adding 10 mL of bacteriostatic water to the 10 mg vial gives a 1 mg/mL solution, scaled for other concentrations. Store the sealed vial at -20C, protected from light; shelf life is 24 months. For research preparation only, not human use.

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Reviews

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4.7
68 verified reviews
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Apr 2026
High purity, clear labelling

Lyophilised cake was uniform and dissolved fully. Would appreciate a digital COA portal, but the PDF on request worked fine.

Dr. A. Bianchi · University · IT Verified purchase
Mar 2026
Trustworthy supplier

Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.

K. Wójcik · Research group · PL Verified purchase
Mar 2026
Reference-grade consistency

Reconstitution was clean with no visible particulates. The lot-specific COA matched the assay we ran in-house — purity is exactly as stated.

Dr. M. Hartmann · Research lab · DE Verified purchase
Feb 2026
COA matched our own HPLC

We verify every incoming compound by HPLC; this batch came back within tolerance of the certificate. Dispatch from the EU warehouse was quick.

L. Fischer · University group · AT Verified purchase

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