Research use only · EU-warehoused · COA on every batch · HPLC ≥99% · Shipment 2–5 days
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GHK-Cu Capsules

GHK-Cu Capsules

Lyophilised · ≥98% (HPLC) ·

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Custom quantity
1

Supplied lyophilised. Reconstitution typically uses bacteriostatic water.

Independently third-party tested · COA on every batch · 48h EU dispatch
[01]

Overview

GHK-Cu (copper tripeptide-1) is a naturally occurring tripeptide-copper complex with sequence Gly-His-Lys coordinated to a Cu²⁺ ion; CAS 89030-95-5; molecular weight 402.92 g/mol; molecular formula C₁₄H₂₃CuN₆O₄⁺. The free tripeptide GHK (CAS 49557-75-7, MW 340.38 g/mol) is the copper-free precursor and is a distinct compound. GHK-Cu is found endogenously in human plasma, saliva, and urine and has been studied in wound healing, collagen synthesis, antioxidant response, and tissue remodelling models. For laboratory research use only; not for human or veterinary use.

It begins as a faint blue powder — the colour itself a fingerprint of the copper ion locked at its core. GHK-Cu is the tripeptide glycyl-L-histidyl-L-lysine bound to copper(II), a naturally occurring matrikine first isolated from human plasma and now one of the most intensively studied copper-peptide complexes in regenerative and skin-biology research. The metal is not an impurity but the active heart of the molecule: the histidine-lysine motif cradles Cu(II) in a defined coordination geometry that governs almost everything the complex does.

A copper carrier with a coordination chemistry of its own. The way GHK grips copper has been resolved by X-ray and solution structural work, which compared the redox behaviour of Cu(II)-GHK against related N-terminal motifs and showed how the binding mode tunes the complex's reactivity (Hureau et al., 2011). Thermodynamic titration studies have since quantified just how tightly the tripeptide competes for the metal, framing GHK-Cu as a controlled copper-delivery scaffold rather than a passive chelate (Trapaidze et al., 2012).

Within the broader peptide literature, GHK-Cu is repeatedly catalogued among the matrix-signalling and regenerative peptides of interest to musculoskeletal, dermatological and gerontology research programmes (Rahman et al., 2026; Mavrych et al., 2026).

What the research explores. Across cell-culture and animal systems, GHK-Cu has been investigated along several converging lines:

  • Wound-repair & tissue remodelling — studied as a copper-tripeptide scaffold for skin-healing and fascia-regeneration endpoints in cell and animal models (Aguilar et al., 2026; Wang et al., 2026).
  • Antioxidant & anti-inflammatory signalling — examined for attenuation of copper- and LPS-induced inflammation in a zebrafish-larvae model (Hu et al., 2026).
  • Ageing & longevity pathways — explored for lifespan and mitochondrial-pathway effects in C. elegans and for behavioural and hippocampal endpoints in aged mice (Wen et al., 2026; Mazzola et al., 2026).

The activity described here is drawn from in-vitro and animal studies; it characterises biological behaviour in experimental models and does not establish efficacy or safety in humans. Full citations are listed under the Scientific References tab.

Physicochemical profile. CAS No. 89030-95-5 · Molecular formula C14H24N6O4·Cu (copper complex) · Molecular weight 401.93 g/mol · Sequence Gly-His-Lys · copper(II) complex · Appearance: Blue lyophilized powder (copper complex) · Solubility: Soluble in water.

Specification & quality. Each bottle contains 60 HPMC (vegan) capsules, each providing 2mg of GHK-Cu at ≥98% (HPLC). Encapsulated — no reconstitution required. Every batch is independently third-party tested, and a Certificate of Analysis (COA) is available. Store at -20°C, protect from light and moisture; shelf life 24 months from the manufacture date. EU warehoused.

This product is intended for laboratory research use only (RUO). It is not a drug, food, cosmetic, or dietary supplement, and is not for human or veterinary use, ingestion, or diagnostic application. Handling is restricted to qualified research professionals operating in an appropriately equipped laboratory.

Supplied for in-vitro laboratory research use only (RUO). Not a drug, food or supplement; not for human or veterinary use.

[04]

Quality & COA

Certificate of Analysis
Lot-specific COA with every order

Certificate of Analysis — lot-specific COA ships with every order and is available on request.

Each lot is tested by an independent third-party laboratory for identity (mass spectrometry) and purity (HPLC). The Certificate of Analysis for your specific batch ships with the order and is available on request — no house data, no exceptions.

HPLC purity
≥98% (HPLC)
Method
HPLC + MS
Endotoxin
Reported
[02]

Data Sheet

CAS number89030-95-5
Molecular formulaC14H24N6O4·Cu (copper complex)
Molecular weight401.93
SequenceGly-His-Lys · copper(II) complex
Purity≥98% (HPLC)
Physical formBlue lyophilized powder (copper complex)
Quantity60 capsules
SolubilitySoluble in water
StorageStore at -20°C, protect from light and moisture
ReconstitutionEncapsulated — no reconstitution required.
Shelf life24 months from manufacture date
Dose per capsule2mg
Capsule materialHPMC (Vegan)
OriginEU · Slovakia
ClassificationResearch use only
[03]

Scientific References

01 Rahman OF, Lee SJ, Seeds WA Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews. 2026;10(1). PMID: 41490200. doi:10.5435/JAAOSGlobal-D-25-00236. PubMed 02 Mayfield CK, Bolia IK, Feingold CL, Lin EH, Liu JN, Rick Hatch GF et al. Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians. The American journal of sports medicine. 2026;54(1):223-229. PMID: 41476424. doi:10.1177/03635465251357593. PubMed 03 Mendias CL, Awan TM Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance. Sports medicine (Auckland, N.Z.). 2026. PMID: 41966639. doi:10.1007/s40279-026-02437-0. PubMed 04 Mavrych V, Shypilova I, Bolgova O Therapeutic peptides in gerontology: mechanisms and applications for healthy aging. Frontiers in aging. 2026;7:1790247. PMID: 42021992. doi:10.3389/fragi.2026.1790247. PubMed 05 Renke G, Chinellato L Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives. International journal of molecular sciences. 2026;27(9). PMID: 42123471. doi:10.3390/ijms27093890. PubMed 06 Arciola CR, Panichi V, Bua G, Costantini S, Bottau G, Ravaioli S et al. Smart Healing for Wound Repair: Emerging Multifunctional Strategies in Personalized Regenerative Medicine and Their Relevance to Orthopedics. Antibiotics (Basel, Switzerland). 2026;15(1). PMID: 41594073. doi:10.3390/antibiotics15010036. PubMed 07 Hu J, Zhang C, Wang F Glycyl-L-histidyl-L-lysine-Cu2(+) (GHK-Cu) Attenuates CuSO(4) or LPS induced-inflammation in Zebrafish larvae model. European journal of pharmacology. 2026;1023:178880. PMID: 41997403. doi:10.1016/j.ejphar.2026.178880. PubMed 08 Mazzola J, Rosenfeld M, Tucker M, Wezeman J, Ladiges W, Liao G Middle-aged mice treated with GHK-Cu peptide administered intraperitoneally or intranasally show behavioral rescue but divergent hippocampal aging programs. Research square. 2026. PMID: 42245779. doi:10.21203/rs.3.rs-9520102/v1. PubMed 09 Wang R, Xu Y, Saiding Q, Ling S, Yu J, Zhuang Y et al. Golgi-targeted copper delivery strategy via enhancing copper-dependent proteins' activity for fascia regeneration. Journal of controlled release : official journal of the Controlled Release Society. 2026;390:114521. PMID: 41371501. doi:10.1016/j.jconrel.2025.114521. PubMed 10 Wen H, Zhao K, Luo X, Pu J, Li Y, Dou Y et al. The GHK-Cu delays aging in Caenorhabditis elegans via coordinated regulation of mitochondrial function and activation of DAF-16/SKN-1 pathways. Biogerontology. 2026;27(3). PMID: 42084774. doi:10.1007/s10522-026-10444-x. PubMed 11 Chen JS, Zhu H, Chai TQ, Yang FQ The Laccase-like Property of GHK-Cu and Its Applications in Colorimetric Sensing of Phenolic Compounds. Biosensors. 2026;16(4). PMID: 42041438. doi:10.3390/bios16040217. PubMed 12 Skurski P, Anusiewicz I Carbonless amino acids and a carbonless GHK peptide. Physical chemistry chemical physics : PCCP. 2026;28(14):8675-8691. PMID: 41859865. doi:10.1039/d6cp00567e. PubMed 13 Aguilar L, Garcia Gabastú E, Schaffner M, Justet C, Santos Mendes LF, Palmeira-Mello MV et al. Copper(II)-Tripeptide Complexes as Potential Skin Healing Agents: Synthesis, Characterization, and Wound Repair Ability. ChemMedChem. 2026;21(8):e202501023. PMID: 42047624. doi:10.1002/cmdc.202501023. PubMed 14 Ye H, Zhen Y, Chen S, Lin Y, Xu X, Yu Y et al. Elastic cationic liposomal nanogels: a novel platform for topical nicotinamide mononucleotide delivery. Journal of liposome research. 2026;36(1):13-24. PMID: 41383026. doi:10.1080/08982104.2025.2584982. PubMed 15 Greco V, Lanza V, Tomasello B, Naletova I, Cairns WRL, Sciuto S et al. Copper Complexes with New Glycyl-l-histidyl-l-lysine-Hyaluronan Conjugates Show Antioxidant Properties and Osteogenic and Angiogenic Synergistic Effects. Bioconjugate chemistry. 2025;36(4):662-675. PMID: 40123442. doi:10.1021/acs.bioconjchem.4c00545. PubMed 16 Hureau C, Eury H, Guillot R, Bijani C, Sayen S, Solari PL et al. X-ray and solution structures of Cu(II) GHK and Cu(II) DAHK complexes: influence on their redox properties. Chemistry (Weinheim an der Bergstrasse, Germany). 2011;17(36):10151-60. PMID: 21780203. doi:10.1002/chem.201100751. PubMed 17 Trapaidze A, Hureau C, Bal W, Winterhalter M, Faller P. Thermodynamic study of Cu2+ binding to the DAHK and GHK peptides by isothermal titration calorimetry (ITC) with the weaker competitor glycine. Journal of biological inorganic chemistry. 2012;17(1):37-47. PMID: 21898044. doi:10.1007/s00775-011-0824-5. PubMed

References are illustrative of the research literature surrounding this compound. All claims relate to in-vitro and animal models only.

[05]

FAQ

GHK-Cu is the tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys) bound to copper(II), forming a defined blue copper-peptide complex. It is studied in cell and animal models for wound-repair, antioxidant and tissue-remodelling endpoints. Condor Research supplies it strictly as a Research Use Only reference compound for in vitro and animal studies, not for human or veterinary use.

The blue colour comes from the copper(II) ion coordinated by the histidine and lysine residues of the tripeptide — the metal is integral to the complex, not a contaminant. Structural studies have resolved exactly how GHK grips copper and how that geometry shapes its redox chemistry (Hureau et al., 2011). The product is therefore presented as a copper complex, and is supplied for laboratory research use only.

Both are copper(II) tripeptide complexes that appear as blue lyophilised powders. GHK-Cu (Gly-His-Lys) is most studied around wound-healing, antioxidant and dermal-remodelling endpoints, while AHK-Cu (Ala-His-Lys) swaps the N-terminal glycine for alanine and is more often examined in hair-follicle and angiogenesis models. They address different research questions despite sharing the His-Lys copper-binding motif. Both are supplied as research-use-only reference compounds.

GHK-Cu is a copper-bound tripeptide studied as a matrikine in skin-repair, antioxidant and remodelling models, where the copper ion is central to its activity. BPC-157 is a 15-residue gastric-derived peptide investigated mainly in soft-tissue and gastrointestinal injury paradigms and carries no metal. They belong to different structural classes and serve distinct experimental questions. Both are supplied strictly for research use only.

GHK-Cu is a copper-peptide complex studied in wound-repair and dermal models, whereas NMN is a small-molecule NAD+ precursor studied in metabolic and mitochondrial pathways. Interestingly, parts of the GHK literature touch ageing biology, with lifespan and mitochondrial-pathway effects reported in C. elegans (Wen et al., 2026) — a different mechanistic angle than NMN's NAD+ route. They are complementary research tools, each supplied for research use only.

Yes. Condor Research supplies GHK-Cu strictly as a Research Use Only reference compound to professionals and institutions, not as a medicine, supplement or product for human or veterinary use. Buyers are responsible for confirming import legality in their own country. Questions: info@condorresearch.com.

The capsule is a pre-weighed solid format that simplifies laboratory handling and inventory of a fixed quantity of the copper-peptide complex, with light- and moisture-sensitive material contained in an HPMC (vegan) shell. It is a measured solid format, not a dose, and does not imply consumption of any kind. For laboratory research use only. Not for human or veterinary use.

No. Unlike lyophilised vials, these are encapsulated — no reconstitution required. Each HPMC (vegan) capsule contains a fixed 2mg quantity of GHK-Cu in solid form for laboratory handling. This format is for research use only and is not intended for ingestion or human use.

Each bottle contains 60 HPMC (vegan) capsules, each providing 2mg of GHK-Cu at ≥98% (HPLC) purity. The capsules are independently third-party tested. The stated quantity refers to a pre-weighed laboratory reference format, not a human dose, and the material is for research use only.

Our GHK-Cu has CAS No. 89030-95-5, molecular formula C14H24N6O4·Cu (copper complex) and a molecular weight of 401.93 g/mol, with the sequence Gly-His-Lys · copper(II) complex. It is supplied as a blue lyophilised powder (copper complex), soluble in water. For laboratory research use only.

Yes. Every GHK-Cu batch is tested by an independent third-party laboratory by HPLC for identity and purity (≥98%), and each lot ships with a lot-specific Certificate of Analysis. To request the COA for your batch, contact info@condorresearch.com. For laboratory research use only. Not for human or veterinary use.

[06]

Reviews

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4.7
64 verified reviews
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Apr 2026
High purity, clear labelling

Lyophilised cake was uniform and dissolved fully. Would appreciate a digital COA portal, but the PDF on request worked fine.

Dr. A. Bianchi · University · IT Verified purchase
Mar 2026
Trustworthy supplier

Identity by MS confirmed in our facility. Communication around storage and handling was precise and professional.

K. Wójcik · Research group · PL Verified purchase
Mar 2026
Reference-grade consistency

Reconstitution was clean with no visible particulates. The lot-specific COA matched the assay we ran in-house — purity is exactly as stated.

Dr. M. Hartmann · Research lab · DE Verified purchase
Feb 2026
COA matched our own HPLC

We verify every incoming compound by HPLC; this batch came back within tolerance of the certificate. Dispatch from the EU warehouse was quick.

L. Fischer · University group · AT Verified purchase

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