A myth-versus-mechanism fact-check on one of wellness’s most abused phrases. The intestinal barrier is real biology; “leaky gut” as a catch-all diagnosis is not — and the one peptide that put the hypothesis to a large human test tells a sobering story.
Larazotide (AT-1001) is an eight-amino-acid peptide designed to tighten the gut’s molecular seams by antagonising the zonulin pathway. It is the only “leaky gut” molecule with a serious clinical dossier — and its largest trial is also the most honest thing about it.
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