Metabolic Research Compounds

Metabolic research compounds are reference materials studied in preclinical models of energy metabolism — NNMT inhibition, ERR agonism, AMPK activation and related signalling used in exercise-mimetic research. This category groups the small molecules and peptide fragments most investigated across those pathways so researchers can compare mechanism, format and documentation in one place. Every item is supplied strictly as Research Use Only (RUO) material with a batch Certificate of Analysis; nothing here is intended for human or veterinary use.
Mechanisms investigated
Metabolic-pathway research converges on a small set of enzymatic and receptor targets, and these compounds map onto different ones — they are not interchangeable:

NNMT inhibition (5-Amino-1MQ): studied as a small-molecule inhibitor of nicotinamide N-methyltransferase, an enzyme implicated in cellular NAD⁺/SAM metabolism.
ERR agonism (SLU-PP-332): investigated as a synthetic pan-ERR (estrogen-related receptor) agonist studied for its effects on mitochondrial gene expression and oxidative metabolism, a mechanism central to exercise-mimetic research.
Monoamine reuptake modulation (Tesofensine): a small molecule originally studied in central-nervous-system research, of interest for its monoaminergic mechanism.
Selective estrogen receptor modulation (Enclomiphene): studied for its action at the hypothalamic-pituitary-gonadal axis.
AMPK activation (AICAR): a well-characterised AMP-activated protein kinase agonist used extensively in cellular energy-sensing research.
Lipolytic-fragment signalling (AOD-9604): a modified fragment of human growth hormone (hGH 176-191) studied in isolated metabolic-signalling models.

Comparison
CompoundClassPathway / targetResearch focusFormat
5-Amino-1MQSmall moleculeNNMT inhibitionNAD⁺ / SAM metabolismVial
5-Amino-1MQ CapsulesSmall moleculeNNMT inhibitionNAD⁺ / SAM metabolismCapsules
SLU-PP-332Small moleculePan-ERR agonismMitochondrial gene expressionVial
SLU-PP-332 CapsulesSmall moleculePan-ERR agonismMitochondrial gene expressionCapsules
Tesofensine CapsulesSmall moleculeMonoamine reuptakeCNS / monoaminergic signallingCapsules
Enclomiphene CapsulesSmall moleculeEstrogen receptor (SERM)HPG-axis signallingCapsules
AICARSmall moleculeAMPK activationCellular energy sensingVial
AOD-9604Peptide fragmenthGH fragment (176-191) signallingLipolytic-pathway signallingVial
AOD-9604 CapsulesPeptide fragmenthGH fragment (176-191) signallingLipolytic-pathway signallingCapsules
GLP-3 (Reta)PeptideIncretin receptorMetabolic signalling researchVial

Comparison

What pathways do metabolic research compounds target?

This category groups compounds studied across distinct metabolic-signalling nodes: NNMT inhibition (5-Amino-1MQ), pan-ERR agonism (SLU-PP-332), AMPK activation (AICAR), monoamine reuptake (Tesofensine), estrogen-receptor modulation (Enclomiphene) and hGH-fragment signalling (AOD-9604). See our exercise mimetics overview for how these mechanisms relate.

Is SLU-PP-332 the same mechanism as 5-Amino-1MQ?

No. SLU-PP-332 is a synthetic pan-ERR agonist studied for effects on mitochondrial gene expression, while 5-Amino-1MQ is an NNMT inhibitor studied in NAD⁺/SAM metabolism research. They are structurally and mechanistically distinct compounds grouped here because both are used in exercise-mimetic research models. See our 5-Amino-1MQ vs SLU-PP-332 comparison.

Are 5-Amino-1MQ and SLU-PP-332 legal to purchase for research in Europe?

Legal and regulatory status varies by compound and by EU member state. Both are supplied strictly as Research Use Only material, not for human or veterinary use. See our per-compound legal-status guides for 5-Amino-1MQ and Tesofensine.

Is AOD-9604 a peptide or a small molecule, and how does it differ from the other compounds in this category?

AOD-9604 is a peptide fragment (a modified fragment of human growth hormone, hGH 176-191), unlike the small molecules also listed here (5-Amino-1MQ, SLU-PP-332, Tesofensine, Enclomiphene, AICAR). It is studied in isolated lipolytic-pathway signalling models. See our AOD-9604 research guide.

Do you provide a Certificate of Analysis for every compound in this category?

Yes. Every compound ships as research-use-only material with a batch-specific COA covering identity and purity by HPLC and mass spectrometry.