{ "name": "Epitalon Evidence Card: census of the Epitalon and Epithalamin PubMed literature", "creator": "Condor Research", "url": "https://condorresearch.com/research/what-is-epitalon/", "license": "https://creativecommons.org/licenses/by/4.0/", "date_cutoff": "2026-10-17", "version": "1.0-rc", "creator_name": "Condor Research Editorial", "citation": "Condor Research Editorial. Epitalon Evidence Card: a census of the Epitalon and Epithalamin literature. Version 1.0-rc, 2026-10-17. https://condorresearch.com/research/what-is-epitalon/", "declaration_of_interest": "Condor Research sells Epitalon as a research reagent and funded this work.", "changelog": [ { "version": "1.0-rc2", "date": "2026-10-18", "changes": "RUO review wording changes" }, { "version": "1.0-rc", "date": "2026-10-17", "changes": "Key findings box; exact FDA listing of human studies; Brunel telomerase comparisons separated, Fig. 1D label noted; Kiev and Ivko/WHJ correspondences marked inferred; Kiev 2003 treatment years 1992-1994; frequency wording removed from Epithalamin table; randomisation not reported (not not randomised)." }, { "version": "0.95", "date": "2026-10-17", "changes": "14 full texts read (not redistributed). Human tables rebuilt from full text; Ivko 2020 and World Heart J 2021 merged as one cohort; lifespan rebuilt by cohort (2 of 5 mouse cohorts significant on mean; SAM moved from not assessable to n.s.; SAMR-1 last-10% shorter; CBA maximum one animal); melatonin null detailed; Brunel 2025 reclassified to partial, internally inconsistent replication after inspecting corrected figures; Kiev Epithalamin reports flagged as overlapping with inconsistent n and controls; retinal-extract origin story added." }, { "version": "0.9", "date": "2026-10-17", "changes": "First public version: census, authorship concentration with sensitivity, replication categories, blind double coding (n=40), Brunel correction reviewed, PCAC tally as reported pending minutes." } ], "data_dictionary": { "records[].pmid": "PubMed identifier", "records[].year": "publication year (PubMed)", "records[].title": "article title", "records[].journal / journal_abbr": "journal name and ISO abbreviation", "records[].language": "MEDLINE language codes", "records[].pub_types": "MEDLINE publication types", "records[].doi": "DOI from PubMed, if any", "records[].authors": "full author list as in PubMed (surname + initials)", "records[].affiliations": "all affiliation strings", "records[].substance": "epitalon | epithalamin | both | other_pineal_extract | false_positive (manual)", "records[].model": "in_vitro | animal | human | review | chemistry_analytical | in_silico | other (manual)", "records[].note": "classifier note", "records[].group": "origin_group | origin_network | independent (= no authorship link), headline definition", "records[].country / country_source": "country from affiliation or inferred from language (flagged)", "records[].matched": "which census query retrieved the record", "records[].mesh_humans / mesh_animals": "MeSH check tags", "metrics": "aggregate counts per literature", "authorship_sensitivity": "five definitions plus affiliation and funding checks", "double_coding": "blind second-coder sample, agreement and kappa", "key_findings": "replication ledger with categories", "replication_search": "per-finding PubMed queries and unlinked hits", "human_studies_*": "tables shown on the page", "lifespan_cohorts": "rodent lifespan table by cohort, from full text where available", "fulltexts_read": "list of full texts read (texts not included)", "regulatory": "regulatory table with sources and check date", "registries": "raw registry responses", "evidence_card": "card values and comparison with the 2026-09-22 index row" }, "method": { "pubmed_queries": { "epitalon": { "query": "(\"alanyl-glutamyl-aspartyl-glycine\"[nm] OR epitalon[tiab] OR epithalon[tiab] OR epithalone[tiab] OR epitalone[tiab] OR \"Ala-Glu-Asp-Gly\"[tiab] OR AEDG[tiab] OR \"alanyl-glutamyl-aspartyl-glycine\"[tiab])", "count": 174 }, "epithalamin": { "query": "(\"epithalamin\"[nm] OR epithalamin*[tiab] OR epitalamin*[tiab] OR \"pineal peptide preparation\"[tiab] OR \"pineal polypeptide extract\"[tiab])", "count": 107 }, "run_date": "2026-10-17", "union": 256 }, "classification_scheme": { "substance": [ "epitalon", "epithalamin", "both", "other_pineal_extract", "false_positive" ], "model": [ "in_vitro", "animal", "human", "review", "chemistry_analytical", "in_silico", "other" ], "group": { "origin_group": "author normalised to Khavinson V, Anisimov V, Morozov V or Dilman V, or affiliation to the Institute of Bioregulation and Gerontology", "origin_network": "no core author, but at least one author who co-signed a core record", "independent": "neither" } }, "reader": "single reader, title + abstract (MeSH/publication type when no abstract)", "network_size": 284, "network_authors": [ "abramova t", "aleksandrov v", "alimova i", "anisimov s", "antoniuk shcheglova i", "antonucci i", "antonyuk shcheglova i", "artiukhina z", "artyukhina z", "arutiunov v", "arutyunyan a", "ashapkin v", "avolio f", "azarova m", "azarskova m", "bablishvili n", "ballerini p", "barabanova s", "baranov v", "bashurin d", "baturin d", "ben hur h", "bespalov v", "bokheler k", "bokhman i", "bologna g", "bondarenko l", "bondarev i", "brodskii v", "bruno a", "bukaeva i", "bukalev a", "butenko g", "butyugov a", "caputi s", "chaban t", "chalisova n", "chernova a", "davydenko v", "dekster l", "diatlov r", "diatlova a", "dilovarova t", "diomede f", "djeridane y", "dorovskii a", "dovizio m", "dragunova v", "drobintseva a", "dudkov a", "dvalishvili n", "dyakonov m", "dyatlova a", "dzhokhadze t", "efimova o", "egorova v", "ekhvalova t", "esposito j", "fateeva v", "fedoreyeva l", "fomina n", "franceschi c", "franceschi k", "frantsiiants e", "gabaeva m", "gatta m", "giambuzzi g", "glushikhina m", "golubev a", "goncharova n", "gordova l", "grigorev a", "grigorev e", "grigorian r", "grigoryan r", "gromova l", "guarnieri s", "gumen a", "gutop e", "gvazava i", "iakovleva r", "ilin n", "ilina a", "ilina t", "iliukha v", "ilyukha v", "imyanitov e", "ivko o", "izmaylov d", "karpov r", "katanugina a", "kazakova t", "kharchenko p", "khavincon b", "khizhkin e", "khotin m", "kireev i", "klimenko a", "kochnev i", "kolchina n", "kolomijtseva g", "koltsova a", "komarov f", "koncevaya e", "konovalov s", "konovalov y", "konstantinova n", "kopylov a", "kopylova g", "korf h", "korkushko o", "kormilets d", "korneva e", "kossoy g", "kossoy n", "kost n", "kotlova l", "kovalenko r", "kozina l", "kozinets i", "krapivin m", "krasichkov a", "kraskovskaya n", "krasovskaia i", "krieger d", "kudriavtseva t", "kuznetsova e", "kuznik b", "kvetnaya t", "kvetnoy i", "labunets i", "lanuti p", "lapin b", "lapina e", "leonteva d", "lezhava t", "linkova n", "lyzlova l", "lyzlova s", "magdich l", "maksiuk t", "malinin v", "manchini r", "mancini r", "manokhina r", "marchenko v", "marino a", "martinotti s", "martirosyan y", "maryanovich a", "medvedev d", "melnikov a", "merkureva g", "mikhalski a", "mikhalskii s", "mikheev v", "milillo c", "miretskii g", "mironova e", "mitneva m", "mogilev v", "monaselidze j", "mordovin v", "morosov v", "morozov a", "musienko n", "mylnikov s", "nazarova l", "nechaeva n", "nichik t", "nikitina a", "noskin l", "novikova n", "novikova t", "nozdrachev a", "obukhova l", "okulov v", "oleinik t", "oparina t", "orlova a", "orlova o", "ostroumova m", "ovchinnikova k", "parkhomenko e", "pateyuk a", "pavlova n", "pendina a", "penniiainen v", "petrova l", "petrova o", "petrovskaia kaminskaia a", "petukhov m", "pishel i", "pivanovich i", "pliss g", "polyakova v", "popovich i", "popuchiev v", "procopio a", "prokopenko v", "pronyaeva v", "provinciali m", "provintsiali m", "pulcini r", "raikhlin n", "razumovskaya a", "razumovskii m", "razumovsky m", "reiter r", "robuffo i", "rodnichenko a", "romashevskii b", "rosenfeld s", "rozenfeld s", "rubinskii a", "rudskoy a", "ruggieri a", "rybakina e", "ryzhak g", "sakhenberg e", "sallese m", "semchenko a", "semenchenko a", "semenchenko g", "shanin s", "sharkovich z", "sharova a", "sharova n", "shataeva l", "shatilo v", "shchudrova t", "shmalii a", "shtylik a", "shustov s", "shutak t", "sibarov d", "sidorenko i", "simeone p", "simonenkova v", "sinjari b", "slepushkin v", "smirnova e", "smirnova t", "sokolov o", "solovyov a", "sopova i", "stvolinskii s", "svechkina e", "tarnovskaya s", "tendler e", "tikhonov a", "timofeeva n", "togo e", "toniato e", "touitou y", "trofimov a", "trofimova s", "trubiani o", "umnov r", "vanyushin b", "vaskovsky b", "vengerin a", "verbovaia t", "vinogradova i", "vladimirova l", "volkov m", "yakovleva n", "yakutseni p", "yarilin a", "yashin a", "yuzhakov v", "zabezhinski m", "zamorskii i", "zandbank j", "zavarzina n", "zeleniuk v", "zemchikhina v", "zhekalov a", "zimina o", "zoloev g", "zolotarev i", "zubzhitskaya l", "zusman i", "zykova v" ] }, "evidence_card": { "cutoff": "2026-10-17", "index_method": { "query": "(\"Epitalon\" OR \"epithalon\" OR \"AEDG\" OR \"Ala-Glu-Asp-Gly\" OR \"AE-0 peptide\" OR \"alanyl-glutamyl-aspartyl-glycine\")", "total": 174, "humanos": 58, "ensayos_pm_old_syntax": 0, "ensayos_pm": 1 }, "previous_row_2026_09_22": { "cid": "219042", "nombres": [ "Epitalon", "epithalon", "AEDG", "Ala-Glu-Asp-Gly", "AE-0 peptide", "alanyl-glutamyl-aspartyl-glycine", "EX-A13753", "TP1456" ], "descartados": [ "Glycine, L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-" ], "total": 173, "humanos": 57, "ensayos_pm": 0, "ct_total": 0, "ct_intervencion": 0, "confianza": "media", "catalogo": true }, "curated_census": { "epitalon_records": 165, "false_positives_removed": 9, "by_model": { "animal": 80, "in_vitro": 44, "review": 24, "chemistry_analytical": 8, "in_silico": 4, "human": 3, "other": 2 }, "by_group": { "origin_group": 120, "origin_network": 33, "independent": 12 }, "pt_clinical_trial": 1 }, "ct_total": 0, "ct_intervencion": 0, "isrctn": 0, "ctis": 0, "confianza": "alta (censo curado registro a registro)" }, "metrics": { "epitalon": { "n": 165, "by_model": { "animal": 80, "in_vitro": 44, "review": 24, "chemistry_analytical": 8, "in_silico": 4, "human": 3, "other": 2 }, "by_group": { "origin_group": 120, "origin_network": 33, "independent": 12 }, "primary_n": 139, "primary_by_group": { "origin_group": 104, "origin_network": 30, "independent": 5 }, "human_by_group": { "origin_group": 3 }, "by_country": { "Russia": 136, "Ukraine": 5, "Georgia": 4, "null": 3, "Germany": 2, "Israel": 2, "Italy": 2, "China": 2, "United Kingdom": 2, "USA": 2, "France": 1, "Belgium": 1, "South Korea": 1, "Poland": 1, "Saudi Arabia": 1 }, "by_language": { "eng": 108, "rus": 56, "ukr": 1 }, "by_epoch_model": { "1975-1989": {}, "1990-1999": {}, "2000-2009": { "animal": 69, "in_vitro": 19, "review": 5, "chemistry_analytical": 4, "human": 2, "other": 1, "in_silico": 1 }, "2010-2019": { "in_vitro": 13, "animal": 10, "review": 8, "chemistry_analytical": 4, "in_silico": 2 }, "2020-2026": { "in_vitro": 12, "review": 11, "human": 1, "in_silico": 1, "other": 1, "animal": 1 } }, "by_year": { "2000": 6, "2001": 13, "2002": 20, "2003": 14, "2004": 11, "2005": 5, "2006": 10, "2007": 10, "2008": 10, "2009": 2, "2010": 2, "2011": 6, "2012": 4, "2013": 7, "2014": 3, "2015": 6, "2016": 2, "2017": 4, "2018": 1, "2019": 2, "2020": 8, "2021": 2, "2022": 2, "2023": 2, "2024": 2, "2025": 6, "2026": 5 }, "by_year_group": { "2000": { "origin_group": 6 }, "2001": { "origin_group": 13 }, "2002": { "origin_group": 20 }, "2003": { "origin_group": 13, "independent": 1 }, "2004": { "origin_group": 10, "origin_network": 1 }, "2005": { "origin_group": 5 }, "2006": { "origin_network": 6, "origin_group": 4 }, "2007": { "origin_group": 5, "origin_network": 5 }, "2008": { "origin_group": 5, "origin_network": 5 }, "2009": { "origin_group": 1, "origin_network": 1 }, "2010": { "origin_network": 2 }, "2011": { "origin_network": 3, "origin_group": 3 }, "2012": { "origin_group": 3, "origin_network": 1 }, "2013": { "origin_network": 4, "origin_group": 3 }, "2014": { "origin_group": 2, "origin_network": 1 }, "2015": { "origin_group": 4, "independent": 1, "origin_network": 1 }, "2016": { "origin_group": 2 }, "2017": { "origin_group": 3, "origin_network": 1 }, "2018": { "origin_group": 1 }, "2019": { "origin_group": 2 }, "2020": { "origin_group": 7, "origin_network": 1 }, "2021": { "origin_group": 2 }, "2022": { "origin_group": 1, "independent": 1 }, "2023": { "origin_group": 1, "origin_network": 1 }, "2024": { "origin_group": 2 }, "2025": { "independent": 4, "origin_group": 2 }, "2026": { "independent": 5 } }, "top_journals": { "Bull Exp Biol Med": 54, "Adv Gerontol": 34, "Neuro Endocrinol Lett": 8, "Georgian Med News": 7, "Vopr Onkol": 5, "Int J Mol Sci": 4, "Ross Fiziol Zh Im I M Sechenova": 3, "Biogerontology": 3 }, "mesh_humans": 54, "pt_clinical_trial": 1, "pt_rct": 0, "since_2020": 27 }, "epithalamin": { "n": 103, "by_model": { "animal": 50, "human": 22, "review": 19, "in_vitro": 11, "chemistry_analytical": 1 }, "by_group": { "origin_group": 60, "independent": 24, "origin_network": 19 }, "primary_n": 84, "primary_by_group": { "origin_group": 50, "independent": 18, "origin_network": 16 }, "human_by_group": { "origin_group": 13, "independent": 5, "origin_network": 4 }, "by_country": { "Russia": 82, "Ukraine": 14, "null": 5, "Poland": 1, "USA": 1 }, "by_language": { "eng": 33, "rus": 65, "ukr": 5 }, "by_epoch_model": { "1975-1989": { "animal": 12, "human": 4, "review": 1 }, "1990-1999": { "animal": 18, "in_vitro": 5, "review": 4, "human": 3, "chemistry_analytical": 1 }, "2000-2009": { "animal": 17, "human": 14, "review": 7, "in_vitro": 6 }, "2010-2019": { "review": 4, "animal": 3, "human": 1 }, "2020-2026": { "review": 3 } }, "by_year": { "1975": 1, "1977": 1, "1979": 2, "1980": 1, "1982": 2, "1983": 2, "1984": 2, "1985": 2, "1986": 1, "1987": 2, "1988": 1, "1990": 4, "1991": 3, "1992": 2, "1993": 5, "1994": 2, "1995": 2, "1996": 1, "1997": 6, "1998": 3, "1999": 3, "2000": 5, "2001": 5, "2002": 9, "2003": 6, "2004": 8, "2005": 3, "2006": 1, "2007": 6, "2008": 1, "2010": 1, "2011": 3, "2012": 3, "2013": 1, "2020": 1, "2025": 1, "2026": 1 }, "by_year_group": { "1975": { "origin_group": 1 }, "1977": { "origin_group": 1 }, "1979": { "origin_group": 2 }, "1980": { "independent": 1 }, "1982": { "origin_group": 2 }, "1983": { "origin_group": 2 }, "1984": { "origin_group": 1, "origin_network": 1 }, "1985": { "independent": 1, "origin_network": 1 }, "1986": { "origin_group": 1 }, "1987": { "independent": 2 }, "1988": { "origin_group": 1 }, "1990": { "origin_group": 2, "independent": 2 }, "1991": { "independent": 2, "origin_group": 1 }, "1992": { "origin_group": 2 }, "1993": { "independent": 3, "origin_group": 1, "origin_network": 1 }, "1994": { "independent": 1, "origin_group": 1 }, "1995": { "origin_group": 2 }, "1996": { "origin_group": 1 }, "1997": { "origin_group": 5, "independent": 1 }, "1998": { "origin_group": 3 }, "1999": { "independent": 2, "origin_group": 1 }, "2000": { "origin_group": 3, "origin_network": 1, "independent": 1 }, "2001": { "origin_group": 4, "independent": 1 }, "2002": { "origin_group": 6, "independent": 2, "origin_network": 1 }, "2003": { "origin_group": 5, "independent": 1 }, "2004": { "origin_group": 4, "independent": 2, "origin_network": 2 }, "2005": { "origin_network": 2, "origin_group": 1 }, "2006": { "origin_group": 1 }, "2007": { "origin_network": 4, "origin_group": 2 }, "2008": { "origin_network": 1 }, "2010": { "origin_network": 1 }, "2011": { "origin_network": 2, "origin_group": 1 }, "2012": { "origin_group": 2, "origin_network": 1 }, "2013": { "origin_group": 1 }, "2020": { "origin_network": 1 }, "2025": { "independent": 1 }, "2026": { "independent": 1 } }, "top_journals": { "Adv Gerontol": 15, "Bull Exp Biol Med": 11, "Vopr Onkol": 9, "Biull Eksp Biol Med": 9, "Dokl Akad Nauk": 5, "Neuro Endocrinol Lett": 5, "Ann N Y Acad Sci": 3, "Probl Endokrinol (Mosk)": 3 }, "mesh_humans": 43, "pt_clinical_trial": 8, "pt_rct": 6, "since_2020": 3 }, "all_valid": { "n": 247, "by_model": { "animal": 120, "in_vitro": 52, "review": 35, "human": 25, "chemistry_analytical": 9, "in_silico": 4, "other": 2 }, "by_group": { "origin_group": 164, "origin_network": 46, "independent": 37 }, "primary_n": 210, "primary_by_group": { "origin_group": 142, "origin_network": 42, "independent": 26 }, "human_by_group": { "origin_group": 16, "independent": 5, "origin_network": 4 }, "by_country": { "Russia": 199, "Ukraine": 16, "null": 11, "Georgia": 4, "Germany": 2, "Israel": 2, "Italy": 2, "China": 2, "United Kingdom": 2, "USA": 2, "France": 1, "Belgium": 1, "South Korea": 1, "Poland": 1, "Saudi Arabia": 1 }, "by_language": { "eng": 132, "rus": 110, "ukr": 5 }, "by_epoch_model": { "1975-1989": { "animal": 15, "human": 4, "review": 1 }, "1990-1999": { "animal": 18, "in_vitro": 5, "review": 4, "human": 3, "chemistry_analytical": 1 }, "2000-2009": { "animal": 74, "in_vitro": 22, "human": 15, "review": 9, "chemistry_analytical": 4, "other": 1, "in_silico": 1 }, "2010-2019": { "in_vitro": 13, "animal": 12, "review": 9, "chemistry_analytical": 4, "human": 2, "in_silico": 2 }, "2020-2026": { "in_vitro": 12, "review": 12, "human": 1, "in_silico": 1, "other": 1, "animal": 1 } }, "by_year": { "1975": 1, "1977": 1, "1978": 1, "1979": 2, "1980": 2, "1981": 1, "1982": 2, "1983": 2, "1984": 2, "1985": 2, "1986": 1, "1987": 2, "1988": 1, "1990": 4, "1991": 3, "1992": 2, "1993": 5, "1994": 2, "1995": 2, "1996": 1, "1997": 6, "1998": 3, "1999": 3, "2000": 10, "2001": 16, "2002": 24, "2003": 17, "2004": 17, "2005": 7, "2006": 11, "2007": 11, "2008": 11, "2009": 2, "2010": 2, "2011": 8, "2012": 5, "2013": 8, "2014": 3, "2015": 6, "2016": 2, "2017": 5, "2018": 1, "2019": 2, "2020": 9, "2021": 2, "2022": 2, "2023": 2, "2024": 2, "2025": 6, "2026": 5 }, "by_year_group": { "1975": { "origin_group": 1 }, "1977": { "origin_group": 1 }, "1978": { "independent": 1 }, "1979": { "origin_group": 2 }, "1980": { "independent": 2 }, "1981": { "independent": 1 }, "1982": { "origin_group": 2 }, "1983": { "origin_group": 2 }, "1984": { "origin_group": 1, "origin_network": 1 }, "1985": { "independent": 1, "origin_network": 1 }, "1986": { "origin_group": 1 }, "1987": { "independent": 2 }, "1988": { "origin_group": 1 }, "1990": { "origin_group": 2, "independent": 2 }, "1991": { "independent": 2, "origin_group": 1 }, "1992": { "origin_group": 2 }, "1993": { "independent": 3, "origin_group": 1, "origin_network": 1 }, "1994": { "independent": 1, "origin_group": 1 }, "1995": { "origin_group": 2 }, "1996": { "origin_group": 1 }, "1997": { "origin_group": 5, "independent": 1 }, "1998": { "origin_group": 3 }, "1999": { "independent": 2, "origin_group": 1 }, "2000": { "origin_group": 8, "origin_network": 1, "independent": 1 }, "2001": { "origin_group": 15, "independent": 1 }, "2002": { "origin_group": 21, "independent": 2, "origin_network": 1 }, "2003": { "origin_group": 15, "independent": 2 }, "2004": { "origin_group": 12, "origin_network": 3, "independent": 2 }, "2005": { "origin_group": 5, "origin_network": 2 }, "2006": { "origin_network": 6, "origin_group": 5 }, "2007": { "origin_network": 6, "origin_group": 5 }, "2008": { "origin_network": 6, "origin_group": 5 }, "2009": { "origin_group": 1, "origin_network": 1 }, "2010": { "origin_network": 2 }, "2011": { "origin_network": 4, "origin_group": 4 }, "2012": { "origin_group": 4, "origin_network": 1 }, "2013": { "origin_group": 4, "origin_network": 4 }, "2014": { "origin_group": 2, "origin_network": 1 }, "2015": { "origin_group": 4, "independent": 1, "origin_network": 1 }, "2016": { "origin_group": 2 }, "2017": { "origin_group": 4, "origin_network": 1 }, "2018": { "origin_group": 1 }, "2019": { "origin_group": 2 }, "2020": { "origin_group": 7, "origin_network": 2 }, "2021": { "origin_group": 2 }, "2022": { "origin_group": 1, "independent": 1 }, "2023": { "origin_group": 1, "origin_network": 1 }, "2024": { "origin_group": 2 }, "2025": { "independent": 4, "origin_group": 2 }, "2026": { "independent": 5 } }, "top_journals": { "Bull Exp Biol Med": 62, "Adv Gerontol": 40, "Vopr Onkol": 14, "Neuro Endocrinol Lett": 11, "Biull Eksp Biol Med": 9, "Georgian Med News": 7, "Dokl Akad Nauk": 5, "Neurosci Behav Physiol": 4 }, "mesh_humans": 90, "pt_clinical_trial": 9, "pt_rct": 6, "since_2020": 28 } }, "key_findings": [ { "id": "telomere_human_cells", "independent_assessment": { "category": "partial_replication_inconsistent", "records": { "40908429": "Read with the correction (41240216) and corrected figures: telomere elongation in 21NT and BT474 cancer lines (ALT, telomerase not significant) and in the panel attributed to HMEC epithelial cells (axis label names IBR.3); IBR.3 fibroblasts (cell type of the 2003 claim) marked not significant in corrected Fig. 1C although the text reports a significant increase; telomerase significance marks in normal-cell panels refer to the comparison with PC3 positive control, while the text reports a fourfold relative increase over untreated IBR.3, not visually confirmed or refuted by the corrected panels; Fig. 1D legend says HMEC but axis label says IBR.3; hTERT increase significant in IBR.3, not significant in HMEC. Peptide gifted by a commercial research supplier; no analytical identity check reported.", "39788414": "conceptual_support: telomerase activity in bovine cumulus-oocyte complexes and embryos, not human somatic cells" } }, "finding": "Telomerase induction / telomere elongation in cultured human cells", "origin": [ "12937682", "15455129", "31761987" ], "independent": [ "40908429" ], "null": [], "note": "31761987: telomere length rose in 5 of 11 donors and fell in 2 (ex vivo lymphocytes). 40908429 carries a published correction (41240216)." }, { "id": "oocyte", "independent_assessment": { "category": "conceptual_support", "records": { "35413689": "mouse oocytes, post-ovulatory ageing in vitro", "39788414": "bovine oocytes and embryos in vitro" }, "comment": "Two independent studies in different species and protocols; no direct replication of either." }, "finding": "Oocyte and embryo quality in vitro (mouse; bovine, with telomerase activity)", "origin": [], "independent": [ "35413689", "39788414" ], "null": [], "note": "Only line of work opened by groups outside the origin network." }, { "id": "lifespan_rodents", "independent_assessment": { "category": "no_information", "records": {}, "comment": "Independent candidates returned by the lifespan search (reviews, in vitro work, Epithalamin clinical records) contain no lifespan experiment with Epitalon." }, "finding": "Lifespan of mice and rats", "origin": [ "11163623", "14501183", "12459848", "15909815", "18856211", "19110597" ], "independent": [], "null": [ "14501183", "15909815", "18856211", "19110597" ], "note": "Full text (5 mouse cohorts): mean lifespan significantly longer in CBA and HER-2/neu; not significant in SHR, SAMP-1, SAMR-1; SAMR-1 longest-lived 10% significantly shorter; CBA maximum = one animal. Rat publications from abstracts only." }, { "id": "tumours_rodents", "independent_assessment": { "category": "no_information", "records": { "42209466": "tangential: Epitalon used as a tool against therapy-induced senescent lymphoma cells; does not test tumour incidence" } }, "finding": "Spontaneous or induced tumours in rodents", "origin": [ "11710291", "11785104", "12049808", "12101568", "12209581", "12428286", "12964022", "16634527" ], "independent": [], "null": [ "11785104" ], "note": "11785104: no inhibitory effect of Epitalon on bladder tumours. 14501183 (lifespan row) also reports no change in total tumour incidence." }, { "id": "melatonin_pineal", "independent_assessment": { "category": "no_information", "records": {}, "comment": "No independent Epitalon study located. The external-laboratory test (12809170, Paris, with origin co-authors) was null. Independent Russian studies of circadian activity exist for Epithalamin (e.g. 2096196), a different substance." }, "finding": "Melatonin secretion and pineal function", "origin": [ "11524632", "11550036", "15664732", "22816096", "17969590", "33280326", "12809170" ], "independent": [], "null": [ "12809170" ], "note": "12809170 (rat pineal perifusion, Paris laboratory with origin co-authors): no effect on basal or stimulated melatonin secretion." }, { "id": "retina", "independent_assessment": { "category": "no_information", "records": {}, "comment": "40493162 (2025, in vitro retinal pigment epithelium) includes origin-group co-authors." }, "finding": "Retina (hereditary degeneration models, retinal cells, one clinical report)", "origin": [ "12170316", "12910293", "12195242", "12937684", "23667897", "40493162" ], "independent": [], "null": [], "note": "" }, { "id": "dna_binding", "independent_assessment": { "category": "no_information", "records": {} }, "finding": "Proposed mechanism: binding to DNA, gene promoters or histones", "origin": [ "14666197", "15990728", "17152370", "19526107", "22117547", "23484211", "23581987" ], "independent": [], "null": [], "note": "In silico modelling and cell-free biophysics; no independent biochemical test located." } ], "replication_search": { "run_date": "2026-10-17", "base_query": "((\"alanyl-glutamyl-aspartyl-glycine\"[nm] OR epitalon[tiab] OR epithalon[tiab] OR epithalone[tiab] OR epitalone[tiab] OR \"Ala-Glu-Asp-Gly\"[tiab] OR AEDG[tiab] OR \"alanyl-glutamyl-aspartyl-glycine\"[tiab]) OR (\"epithalamin\"[nm] OR epithalamin*[tiab] OR epitalamin*[tiab] OR \"pineal peptide preparation\"[tiab] OR \"pineal polypeptide extract\"[tiab]))", "findings": { "telomere_human_cells": { "topic_terms": "(telomer* OR hTERT OR \"alternative lengthening\")", "hits": 14, "independent_candidates": [ "42884164", "42209466", "42021992", "41240216", "40908429", "40141333", "39788414" ] }, "oocyte": { "topic_terms": "(oocyte* OR embryo* OR blastocyst*)", "hits": 9, "independent_candidates": [ "39788414", "35413689" ] }, "lifespan_rodents": { "topic_terms": "(\"life span\" OR lifespan OR longevity OR survival OR mortality)", "hits": 36, "independent_candidates": [ "42884164", "40908429", "35413689", "15314861", "10532103", "8010616" ] }, "tumours_rodents": { "topic_terms": "(tumor* OR tumour* OR carcinogen* OR cancer OR neoplas*)", "hits": 48, "independent_candidates": [ "42209466", "40908429", "25535022", "11589118", "10532103", "3811311" ] }, "melatonin_pineal": { "topic_terms": "(melatonin OR pineal* OR pinealocyte* OR circadian)", "hits": 132, "independent_candidates": [ "42884164", "41490200", "40141333", "35413689", "15455095", "14571286", "12608033", "12195225", "10820844", "9483319", "8010616", "8312549", "8312548", "8097577", "1660663", "1876268", "2163908", "2096196", "3676467", "3883310", "7256169", "7192059", "7001609", "694396" ] }, "retina": { "topic_terms": "(retina* OR retinal OR \"retinitis pigmentosa\")", "hits": 16, "independent_candidates": [ "42884164", "25535022" ] }, "dna_binding": { "topic_terms": "(DNA OR promoter* OR histone* OR \"gene expression\" OR docking)", "hits": 36, "independent_candidates": [ "42209466", "40908429", "35413689" ] } } }, "authorship_sensitivity": { "A_main": { "definition": "Core = Khavinson, Anisimov, Morozov or Dilman by name, or Institute of Bioregulation and Gerontology affiliation; network = any co-author of a core record, any year (headline definition).", "epitalon_all": { "n": 165, "origin_core": 120, "no_link": 12, "origin_network": 33, "linked_pct": 92.7, "core_pct": 72.7 }, "epitalon_primary": { "n": 139, "origin_core": 104, "origin_network": 30, "no_link": 5, "linked_pct": 96.4, "core_pct": 74.8 }, "epitalon_human": { "n": 3, "origin_core": 3, "linked_pct": 100.0, "core_pct": 100.0 } }, "B_core_names_only": { "definition": "Core by the four names only; affiliation ignored.", "epitalon_all": { "n": 165, "origin_core": 111, "no_link": 12, "origin_network": 42, "linked_pct": 92.7, "core_pct": 67.3 }, "epitalon_primary": { "n": 139, "origin_core": 97, "origin_network": 37, "no_link": 5, "linked_pct": 96.4, "core_pct": 69.8 }, "epitalon_human": { "n": 3, "origin_core": 2, "origin_network": 1, "linked_pct": 100.0, "core_pct": 66.7 } }, "C_temporal_network": { "definition": "Network author counts only if the co-authorship with the core happened in the same year or earlier.", "epitalon_all": { "n": 165, "origin_core": 120, "no_link": 16, "origin_network": 29, "linked_pct": 90.3, "core_pct": 72.7 }, "epitalon_primary": { "n": 139, "origin_core": 104, "origin_network": 26, "no_link": 9, "linked_pct": 93.5, "core_pct": 74.8 }, "epitalon_human": { "n": 3, "origin_core": 3, "linked_pct": 100.0, "core_pct": 100.0 } }, "D_strict_network": { "definition": "Network author must have co-signed at least 2 core records.", "epitalon_all": { "n": 165, "origin_core": 120, "no_link": 12, "origin_network": 33, "linked_pct": 92.7, "core_pct": 72.7 }, "epitalon_primary": { "n": 139, "origin_core": 104, "origin_network": 30, "no_link": 5, "linked_pct": 96.4, "core_pct": 74.8 }, "epitalon_human": { "n": 3, "origin_core": 3, "linked_pct": 100.0, "core_pct": 100.0 } }, "E_core_only_no_network": { "definition": "Lower bound: only core records count as linked.", "epitalon_all": { "n": 165, "origin_core": 120, "no_link": 45, "linked_pct": 72.7, "core_pct": 72.7 }, "epitalon_primary": { "n": 139, "origin_core": 104, "no_link": 35, "linked_pct": 74.8, "core_pct": 74.8 }, "epitalon_human": { "n": 3, "origin_core": 3, "linked_pct": 100.0, "core_pct": 100.0 } }, "F_affiliation_only": { "definition": "Only records with an affiliation field; linked = any affiliation to the Institute of Bioregulation and Gerontology (St Petersburg).", "epitalon_with_affiliation": 129, "of_epitalon_all": 165, "bioregulation_affiliated": 69 }, "G_funding": { "definition": "MEDLINE GrantList and 'Research Support' publication types.", "epitalon_with_grantlist": 3, "grant_agencies": [ "European Union-Next Generation EU-under the National Recovery and Resilience Plan (NRRP)", "Ministry of Science and Higher Education of the Russian Federation", "University of Chieti 60% Funding - Ministry of Education - Italy" ], "epitalon_with_research_support_pt": 30, "verdict": "Funding metadata too sparse to classify dependence by funder." } }, "double_coding": { "n": 40, "sampling": "random, seed 20261017, max(40, 15% of 256)", "coder1": "census classification (scripts/classification.py)", "coder2": "independent second coder blind to coder 1 labels (separate model instance given only title, abstract, publication types and MeSH)", "substance": { "percent_agreement": 87.5, "cohen_kappa": 0.784 }, "model": { "percent_agreement": 100.0, "cohen_kappa": 1.0 }, "disagreements": [ { "pmid": "1660663", "field": "substance", "coder1": "M", "coder2": "X", "coder2_note": "unspecified pineal peptides in rats" }, { "pmid": "6548961", "field": "substance", "coder1": "M", "coder2": "X", "coder2_note": "pineal low-MW polypeptide factor FP in rats" }, { "pmid": "9606558", "field": "substance", "coder1": "M", "coder2": "B", "coder2_note": "natural and synthetic cytomedins in tissue culture" }, { "pmid": "15664732", "field": "substance", "coder1": "B", "coder2": "T", "coder2_note": "epitalon in rhesus monkeys" }, { "pmid": "28948547", "field": "substance", "coder1": "T", "coder2": "FP", "coder2_note": "peptide motif sequence analysis, no epitalon" } ], "coder2_labels": [ { "pmid": "303411", "substance": "M", "model": "hu", "note": "pineal extract given to a patient" }, { "pmid": "1660663", "substance": "X", "model": "an", "note": "unspecified pineal peptides in rats" }, { "pmid": "6548961", "substance": "X", "model": "an", "note": "pineal low-MW polypeptide factor FP in rats" }, { "pmid": "7580986", "substance": "M", "model": "an", "note": "epithalamin in rats" }, { "pmid": "8010617", "substance": "M", "model": "rv", "note": "review of epithalamin" }, { "pmid": "9147629", "substance": "M", "model": "an", "note": "epithalamin in Drosophila" }, { "pmid": "9483319", "substance": "M", "model": "an", "note": "bovine pineal peptide extract in rats (Cattle MeSH)" }, { "pmid": "9490497", "substance": "M", "model": "iv", "note": "epithalamin in organotypic culture" }, { "pmid": "9606558", "substance": "B", "model": "iv", "note": "natural and synthetic cytomedins in tissue culture" }, { "pmid": "11276315", "substance": "T", "model": "an", "note": "epithalon in irradiated rats" }, { "pmid": "12087883", "substance": "M", "model": "hu", "note": "epithalamine in patients" }, { "pmid": "12101568", "substance": "T", "model": "an", "note": "Epitalon in transgenic mice" }, { "pmid": "12170316", "substance": "T", "model": "an", "note": "epithalon in rats" }, { "pmid": "12608033", "substance": "M", "model": "hu", "note": "epithalamine in glaucoma patients" }, { "pmid": "14501183", "substance": "T", "model": "an", "note": "Epitalon in mice" }, { "pmid": "14647006", "substance": "T", "model": "iv", "note": "Epitalon on cultured human lymphocytes" }, { "pmid": "15318714", "substance": "M", "model": "hu", "note": "epithalamine in breast cancer patients" }, { "pmid": "15455093", "substance": "T", "model": "iv", "note": "epithalon in human cell coculture" }, { "pmid": "15501020", "substance": "T", "model": "an", "note": "Epitalon survival in mice" }, { "pmid": "15559508", "substance": "T", "model": "rv", "note": "review of geroprotectors incl. Epitalon" }, { "pmid": "15559640", "substance": "M", "model": "hu", "note": "epithalamine in diabetic retinopathy patients" }, { "pmid": "15664732", "substance": "T", "model": "an", "note": "epitalon in rhesus monkeys" }, { "pmid": "16201149", "substance": "M", "model": "an", "note": "epithalamine in old mice" }, { "pmid": "16224563", "substance": "T", "model": "an", "note": "labeled epithalon in pregnant rabbits" }, { "pmid": "16224591", "substance": "T", "model": "an", "note": "epithalon in rats" }, { "pmid": "16224593", "substance": "M", "model": "an", "note": "epithalamin in old mice" }, { "pmid": "16634527", "substance": "T", "model": "an", "note": "Epitalon in mice" }, { "pmid": "17152724", "substance": "T", "model": "an", "note": "epithalon in rats" }, { "pmid": "18830022", "substance": "T", "model": "iv", "note": "Epithalon in lymphocyte cultures" }, { "pmid": "21510076", "substance": "B", "model": "rv", "note": "review of epithalamin and epitalon" }, { "pmid": "23237594", "substance": "B", "model": "an", "note": "epithalamine and epitalon in rats" }, { "pmid": "23484211", "substance": "T", "model": "is", "note": "molecular modelling of AEDG-DNA" }, { "pmid": "25730989", "substance": "T", "model": "an", "note": "epitalon in rhabdomyolysis mice" }, { "pmid": "28509452", "substance": "T", "model": "rv", "note": "review proposing AEDG role" }, { "pmid": "28948547", "substance": "FP", "model": "is", "note": "peptide motif sequence analysis, no epitalon" }, { "pmid": "32362083", "substance": "T", "model": "rv", "note": "review of short peptides incl. AEDG" }, { "pmid": "33280326", "substance": "T", "model": "hu", "note": "AEDG in people" }, { "pmid": "34998008", "substance": "T", "model": "rv", "note": "review of peptide antioxidant properties incl. AEDG" }, { "pmid": "36979488", "substance": "T", "model": "is", "note": "docking of AEDG to transporters" }, { "pmid": "40908429", "substance": "T", "model": "iv", "note": "Epitalon in human cell lines" } ] }, "human_studies_epitalon": [ { "pmid": "12195242", "year": 2002, "design": "two-arm clinical comparison vs conventional therapy; plus 124 rats", "arms": "162 patients examined; 46 controls; Epitalon arm not sized explicitly", "allocation": "randomisation not reported", "blinding": "not reported", "duration": "10 days; follow-up not reported", "losses": "not reported", "declared_primary_endpoint": "none", "outcomes": "ERG amplitudes, visual acuity, visual fields", "result": "ERG rose; 'positive clinical effect' >90%; 31.5% of controls improved", "funding_interests": "not stated; first author's patents on the tetrapeptide cited", "group": "origin_group", "source": "full text" }, { "pmid": "17969590", "year": 2007, "design": "three arms: Epithalamin, Epitalon, saline placebo; plus monkeys", "arms": "15 / 15 / 10 healthy elderly (60-79); analysed low-melatonin subgroup 12 Epitalon vs 8 placebo", "allocation": "'randomised', method not stated", "blinding": "not stated", "duration": "10 days", "losses": "not reported", "declared_primary_endpoint": "none", "outcomes": "plasma melatonin over 24 h", "result": "03:00 melatonin 20 to 49 pg/ml vs unchanged placebo", "funding_interests": "not stated", "group": "origin_group", "source": "full text (Russian)" }, { "pmid": "33280326", "also": "World Heart J 2021;13(1):189-191 (inferred same cohort; full text of PMID 33280326 not available, file supplied was PMID 33342107)", "year": 2020, "design": "placebo-controlled with normal-melatonin reference group", "arms": "75 night-shift women; 35 reference; 40 low-output split peptide/placebo (arm sizes not given)", "allocation": "'randomly divided', method not stated", "blinding": "not stated", "duration": "20 days", "losses": "not reported", "declared_primary_endpoint": "none", "outcomes": "urinary 6-sulfatoxymelatonin; Clock, Cry2, Csnk1e expression", "result": "6-SMT up 1.7-fold; Cry2/Csnk1e shifted toward reference", "funding_interests": "no conflict declared; test product a commercial preparation from the manufacturer (formulation not described here)", "age_discrepancy": "40-59 (World Heart J) vs 40-50 (FDA reading of Ivko)", "group": "origin_group", "source": "World Heart J full text + FDA briefing" } ], "human_studies_epithalamin_rct": [ { "pmid": "10532103", "population": "100 patients, locally advanced cervical cancer", "design": "RCT; Epithalamin part of multimodal regimen", "outcome": "Survival differences attributed by authors mainly to chemotherapy", "group": "independent" }, { "pmid": "14523363", "arm": "St Petersburg", "population": "94 women 66-94: placebo 22, thymalin 24, Epithalamin 24, both 24 (+ separate group of 20 given both)", "design": "stratification randomisation; described double blind; placebo", "treatment_period": "2 years", "follow_up": "6 years", "outcome": "mortality 81.8% placebo vs 45.8% Epithalamin", "group": "origin_group", "source": "full text" }, { "pmid": "14523363", "arm": "Kiev", "population": "152: placebo 48, thymalin 58, Epithalamin 46", "design": "stratification randomisation; blinding not stated; placebo", "treatment_period": "1992-1994", "follow_up": "8 years", "outcome": "mortality 13.6% vs 8.5% (percentages not whole-number fractions of group sizes)", "group": "origin_group", "source": "full text" }, { "pmid": "15452611", "population": "Healthy elderly", "design": "RCT", "outcome": "Night melatonin rose where low, tended to fall where normal", "group": "origin_group" }, { "pmid": "17426848", "population": "70 coronary patients: Epithalamin 36, saline 34; treated 1992-1995", "design": "described randomised; method/blinding not stated; saline", "follow_up": "12 years", "outcome": "alive 28/36 vs 19/34 (reported as '28% lower' mortality)", "note": "melatonin table matches, to rounding, Epithalamin table of 17969590 (healthy elderly)", "group": "origin_group", "source": "full text" }, { "pmid": "18546838", "population": "Women with coronary disease and hypertension", "design": "RCT", "outcome": "Lower 24-h blood pressure, better lipids", "group": "origin_network" }, { "pmid": "22451889", "population": "79 coronary patients 60-69: Epithalamin 39, basic therapy 40; treated 1992-1995", "design": "'divided at random', method/blinding not stated; no placebo", "follow_up": "15 years", "outcome": "alive 26/39 vs 16/40; Kaplan-Meier, log-rank", "note": "same institute, treatment years and 3-year results as 17426848 with different group sizes and control; correspondence with 17426848 and with the Kiev arm of 14523363 (treated 1992-1994) is INFERRED, not stated by the authors", "group": "origin_group", "source": "full text" } ], "lifespan_cohorts": [ { "pmid": "11163623", "cohort": "female CBA mice", "n_control_treated": "50/50 (60 randomised, 10 killed)", "mean_days": "685/721 significant", "median": "705/732", "last10": "738/842 table; 793 text", "max": "740/1053 (one animal)", "source": "full text" }, { "pmid": "12459848", "cohort": "female HER-2/neu FVB mice", "n_control_treated": "24/24", "mean_days": "289/328 significant", "max": "360/410", "source": "full text" }, { "pmid": "14501183", "cohort": "female SHR mice", "n_control_treated": "50/50 analysed (54 randomised)", "mean_days": "456/455", "median": "512/487", "last10": "709/803 significant", "max": "739/830", "source": "full text" }, { "pmid": "15909815", "cohort": "female SAMP-1 mice", "n_control_treated": "33/30 (saline)", "mean_days": "537/582 n.s.", "median": "582/569", "last10": "693/741 significant", "max": "702/759", "source": "full text (Russian, checked against page image)" }, { "pmid": "15909815", "cohort": "female SAMR-1 mice", "n_control_treated": "33/29 (saline)", "mean_days": "521/546 n.s.", "median": "508/556", "last10": "738/671 significantly shorter", "max": "766/727", "source": "full text (Russian, checked against page image)" }, { "pmid": "18856211", "cohort": "female rats, 3 light regimens", "mean_days": "no change under standard light", "max": "longer under natural/constant light", "source": "abstract" }, { "pmid": "19110597", "cohort": "male rats, 3 light regimens", "mean_days": "virtually unchanged", "other": "slower population ageing rate under natural/constant light", "source": "abstract" } ], "fulltexts_read": [ { "pmid": "12195242", "note": "OCR; numbers checked against page images" }, { "pmid": "14523363" }, { "pmid": "17426848" }, { "pmid": "17969590" }, { "pmid": "22451889" }, { "ref": "World Heart J 2021;13(1):189-191" }, { "pmid": "33280326", "note": "file supplied was a different paper (PMID 33342107); design taken from World Heart J report and FDA briefing" }, { "pmid": "11163623" }, { "pmid": "12459848" }, { "pmid": "14501183" }, { "pmid": "15909815", "note": "Russian OCR; numbers checked against page images" }, { "pmid": "12809170" }, { "pmid": "40908429" }, { "pmid": "41240216", "note": "corrected figures inspected as images" } ], "regulatory": [ { "jurisdiction": "EU centralised", "status": "No current or past authorisation, refusal or current orphan designation located in the Union Register", "source": "https://ec.europa.eu/health/documents/community-register/html/reg_hum_act.htm", "checked": "2026-10-17" }, { "jurisdiction": "EU member states and others", "status": "No approved products in BE, FR, DE, IE, IT, NO, ES, UK, CA, AU; not in Ph. Eur.", "source": "https://www.fda.gov/media/193345/download", "checked": "2026-10-17" }, { "jurisdiction": "EU medicines law", "status": "Directive 2001/83/EC Art. 1(2) definition of medicinal product (presentation / function)", "source": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:02001L0083-20220101", "checked": "2026-10-17" }, { "jurisdiction": "EU clinical trials", "status": "None located (CTIS, EU CTR)", "source": "https://euclinicaltrials.eu/", "checked": "2026-10-17" }, { "jurisdiction": "EU Novel Food", "status": "No entry among 966 catalogue entries; no authorisation located", "source": "https://ec.europa.eu/food/food-feed-portal/screen/novel-food-catalogue/search", "checked": "2026-10-17" }, { "jurisdiction": "WADA", "status": "Not named on 2026 List; S0 covers substances without governmental approval for human therapeutic use; no such approval located", "source": "https://www.wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf", "checked": "2026-10-17" }, { "jurisdiction": "USA approval", "status": "Not approved; no USP monograph", "source": "https://www.fda.gov/media/193345/download", "checked": "2026-10-17" }, { "jurisdiction": "USA compounding 503A", "status": "Formerly category 2, nominations withdrawn; FDA staff recommended against listing (insomnia); PCAC 2026-07-24: 7 in favour, 1 abstention, 4 or 5 against per published tallies, minutes not posted; not in any category on FDA list of 2026-05-14; no later Federal Register action located", "source": [ "https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks", "https://www.fda.gov/media/94155/download", "https://www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026", "https://www.raps.org/resource/fda-advisory-committee-backs-two-more-peptides-rejects-one-for-compounding-list.html", 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"3676467", "year": 1987, "title": "[Changes in the learning ability of epiphysectomized rats].", "journal": "Biulleten' eksperimental'noi biologii i meditsiny", "journal_abbr": "Biull Eksp Biol Med", "language": [ "rus" ], "pub_types": [ "Comparative Study", "English Abstract", "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "animal", "note": "", "group": "independent", "country": "Russia", "country_source": "inferred_language", "matched": "epithalamin", "first_author": "Belozertsev IuA", "n_authors": 2, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/3676467/", "authors": [ "Belozertsev IuA", "Tertyshnik ID" ], "affiliations": [] }, { "pmid": "3811311", "year": 1987, "title": "[Effect of thymalin and epithalamin on the metastasis of experimental tumors irradiated with pulsed laser radiation].", "journal": "Voprosy onkologii", "journal_abbr": "Vopr Onkol", "language": [ "rus" ], "pub_types": [ "Comparative Study", "English Abstract", "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "animal", "note": "", "group": "independent", "country": "Russia", "country_source": "inferred_language", "matched": "epithalamin", "first_author": "Moskalik KG", "n_authors": 1, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/3811311/", "authors": [ "Moskalik KG" ], "affiliations": [] }, { "pmid": "3341127", "year": 1988, "title": "[Effect of tocopherol, phenformin and thymus and pineal polypeptide factors on the transplacental carcinogenic effect of N-nitroso-N-ethylurea in rats].", "journal": "Voprosy onkologii", "journal_abbr": "Vopr Onkol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "inferred_language", "matched": "epithalamin", "first_author": "Bespalov VG", "n_authors": 4, "mesh_humans": false, 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of pineal peptides change the circadian locomotor activity and time-course of forced swimming in rats.", "journal": "Journal of pineal research", "journal_abbr": "J Pineal Res", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1111/j.1600-079x.1990.tb00902.x", "substance": "epithalamin", "model": "animal", "note": "", "group": "independent", "country": null, "country_source": null, "matched": "epithalamin", "first_author": "Arushanian EB", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/2096196/", "authors": [ "Arushanian EB", "Baturin VA", "Ovanesov KB" ], "affiliations": [ "Department of Pharmacology, Medical Institute, Stavropol, U.S.S.R." ] }, { "pmid": "2163908", "year": 1990, "title": "[The effect of epiphyseal peptides on the dynamics of the circadian and minute motor biorhythms in rats].", "journal": "Fiziologicheskii zhurnal SSSR imeni I. M. 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"authors": [ "Egorov VV", "Sorokin EL", "Smoliakova GP" ], "affiliations": [] }, { "pmid": "11087911", "year": 2000, "title": "Effect of epitalon on the lifespan increase in Drosophila melanogaster.", "journal": "Mechanisms of ageing and development", "journal_abbr": "Mech Ageing Dev", "language": [ "eng" ], "pub_types": [ "Comparative Study", "Journal Article" ], "doi": "10.1016/s0047-6374(00)00217-7", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VK", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11087911/", "authors": [ "Khavinson VK", "Izmaylov DM", "Obukhova LK", "Malinin VV" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-West Branch of the Russian Academy of Medical Sciences, 3 Prospect Dynamo, 197110, St. Petersburg, Russia." ] }, { "pmid": "11103316", "year": 2000, "title": "Effect of the Ala-Glu-Asp-Gly peptide on lifespan in Drosophila melanogaster.", "journal": "Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections", "journal_abbr": "Dokl Biol Sci", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11103316/", "authors": [ "Khavinson VKh", "Izmaylov DM", "Obukhova LK", "Malinin VV" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, Northeastern Division, Russian Academy of Medical Sciences, Russia." ] }, { "pmid": "11182832", "year": 2000, "title": "Effect of epithalone on the age-specific changes in the time course of lipid peroxidation in Drosophila melanogaster.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VK", "n_authors": 2, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11182832/", "authors": [ "Khavinson VK", "Myl'nikov SV" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences, Russia. vvm@medport.ru" ] }, { "pmid": "11213728", "year": 2000, "title": "[Effect of cytomedins on development of organotypic culture of various tissues from the internal organs of rats].", "journal": "Tsitologiia", "journal_abbr": "Tsitologiia", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Chalisova NI", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11213728/", "authors": [ "Chalisova NI", "Khavinson VKh", "Davydenko VV", "Dorovskiĭ AA", "Verbovaia TA", "Penniiaĭnen VA" ], "affiliations": [ "Pavlov Institute of Physiology RAS, Institute of Bioregulation and Gerontology RAMS, St. Petersburg." ] }, { "pmid": "11276313", "year": 2000, "title": "Regulating effect of epithalone on gastric endocrine cells in pinealectomized rats.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", 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false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11276315/", "authors": [ "Khavinson VK", "Kvetnoii IM" ], "affiliations": [ "Institute of Bioregulation and Gerontology, North-West Division of the Russian Academy of Medical Sciences, St. Petersburg. ibg@medport.ru" ] }, { "pmid": "11163623", "year": 2001, "title": "Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice.", "journal": "Mechanisms of ageing and development", "journal_abbr": "Mech Ageing Dev", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1016/s0047-6374(00)00184-6", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Anisimov VN", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11163623/", "authors": [ "Anisimov VN", "Khavinson VK", "Mikhalski AI", "Yashin AI" ], "affiliations": [ "Saint Petersburg Institute of Bioregulation and Gerontology, 3, pr. Dynamo, 197110, St. Petersburg, Russia. aging@mail.ru" ] }, { "pmid": "11227856", "year": 2001, "title": "[Effect of pineal peptide on parameters of the biological age and life span in mice].", "journal": "Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova", "journal_abbr": "Ross Fiziol Zh Im I M Sechenova", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Anisimov VN", "n_authors": 10, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11227856/", "authors": [ "Anisimov VN", "Khavinson VKh", "Zavarzina NIu", "Zabezhinskiĭ MA", "Zimina OA", "Popovich IG", "Shtylik AV", "Arutiunian AV", "Oparina TI", "Prokopenko VM" ], "affiliations": [ "Institute of Oncology, 189646, St. Petersburg, Pesochny-2, Russia." ] }, { "pmid": "11329090", "year": 2001, "title": "Reparative effect of epithalon on pineal gland ultrastructure in gamma-irradiated rats.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1017599100641", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VK", "n_authors": 5, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11329090/", "authors": [ "Khavinson VK", "Yakovleva ND", "Popuchiev VV", "Kvetnoi IM", "Manokhina RP" ], "affiliations": [ "Institute of Bioregulation and Gerontology, North-West Division of the Russian Academy of Medical Sciences, St. Petersburg." ] }, { "pmid": "11335874", "year": 2001, "title": "Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals.", "journal": "Neuro endocrinology letters", "journal_abbr": "Neuro Endocrinol Lett", "language": [ "eng" ], "pub_types": [ "Journal Article", "Review" ], "doi": null, "substance": "epithalamin", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Anisimov VN", "n_authors": 3, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11335874/", "authors": [ "Anisimov VN", "Arutjunyan AV", "Khavinson VK" ], "affiliations": [ "Saint-Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. aging@mail.ru" ] }, { "pmid": "11427924", "year": 2001, "title": "Immunohistochemical and morphometric analysis of effects of vilon and epithalon on functional morphology of radiosensitive organs.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1017676104877", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VK", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11427924/", "authors": [ "Khavinson VK", "Yuzhakov VV", "Kvetnoi IM", "Malinin VV", "Popuchiev VV", "Fomina NK" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences, Russian Academy of Medical Sciences, Obninsk." ] }, { "pmid": "11452647", "year": 2001, "title": "[Effect of pineal peptides on neuroendocrine system after pinealectomy].", "journal": "Arkhiv patologii", "journal_abbr": "Arkh Patol", "language": [ "rus" ], "pub_types": [ "Comparative Study", "English Abstract", "Journal Article" ], "doi": null, "substance": "both", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Khavinson VKh", "n_authors": 5, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11452647/", "authors": [ "Khavinson VKh", "Kvetnoĭ IM", "Popuchiev VV", "Iuzhakov VV", "Kotlova LN" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, 119110, St. Petersburg." ] }, { "pmid": "11521426", "year": 2001, "title": "[Effectiveness of bio-regulators in the treatment of diabetic retinopathy].", "journal": "Vestnik oftalmologii", "journal_abbr": "Vestn Oftalmol", "language": [ "rus" ], "pub_types": [ "Comparative Study", "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "human", "note": "104 retinopatía diabética", "group": "origin_group", "country": "Russia", "country_source": "inferred_language", "matched": "epithalamin", "first_author": "Trofimova SV", "n_authors": 2, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/11521426/", "authors": [ "Trofimova SV", "Khavinson VKh" ], "affiliations": [] }, { "pmid": "11524632", "year": 2001, "title": "Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys.", "journal": "Neuro endocrinology letters", "journal_abbr": "Neuro Endocrinol Lett", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "mono", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson V", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11524632/", "authors": [ "Khavinson V", "Goncharova N", "Lapin B" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, 3 Dynamo Prospect, 197110 St. Petersburg, Russia. ibg@medport.ru" ] }, { "pmid": "11550036", "year": 2001, "title": "Regulatory effect of Epithalon on production of melatonin and cortisol in old monkeys.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1017928925177", "substance": "epitalon", "model": "animal", "note": "mono", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Goncharova ND", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11550036/", "authors": [ "Goncharova ND", "Khavinson BK", "Lapin BA" ], "affiliations": [ "Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi. iprim@sochi.net" ] }, { "pmid": "11589118", "year": 2001, "title": "[Physiological and pharmacological characteristics of epiphyseal neuropeptides].", "journal": "Eksperimental'naia i klinicheskaia farmakologiia", "journal_abbr": "Eksp Klin Farmakol", "language": [ "rus" ], "pub_types": [ "Journal Article", "Review" ], "doi": null, "substance": "epithalamin", "model": "review", "note": "", "group": "independent", "country": "Russia", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Arushanian EB", "n_authors": 3, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11589118/", "authors": [ "Arushanian EB", "Arushanian LG", "Simonov IA" ], "affiliations": [ "Pharmacology Department, Stavropol Medical Academy, ul. Mira 310, Stavropol, 355024 Russia." ] }, { "pmid": "11687853", "year": 2001, "title": "Effects of peptides on generation of reactive oxygen species in subcellular fractions of Drosophila melanogaster.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1012588530643", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VK", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11687853/", "authors": [ "Khavinson VK", "Myl'nikov SV", "Oparina TI", "Arutyunyan AV" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences. vvm@medport.ru" ] }, { "pmid": "11710291", "year": 2001, "title": "[Effect of epithalone on growth kinetics and functional morphology of M-1 sarcoma].", "journal": "Voprosy onkologii", "journal_abbr": "Vopr Onkol", "language": [ "rus" ], "pub_types": [ "Comparative Study", "English Abstract", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11710291/", "authors": [ "Khavinson VKh", "Iuzhakov VV", "Kvetnoĭ IM", "Malinin VV" ], "affiliations": [ "Institute of Bioregulation and Gerontology, North-Western Branch of Russian Academy of Medical Sciences, St. Petersburg." ] }, { "pmid": "11713572", "year": 2001, "title": "Tissue-specific effects of peptides.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1013058701974", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VK", "n_authors": 1, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11713572/", "authors": [ "Khavinson VK" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences. ibg@medport.ru" ] }, { "pmid": "11785104", "year": 2001, "title": "[Effect of vilon and epithalone on induction and growth of induced bladder neoplasms in rats].", "journal": "Voprosy onkologii", "journal_abbr": "Vopr Onkol", "language": [ "rus" ], "pub_types": [ "Comparative Study", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Pliss GB", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11785104/", "authors": [ "Pliss GB", "Mel'nikov AS", "Malinin VV", "Khavinson VKh" ], "affiliations": [ "N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg." ] }, { "pmid": "11865335", "year": 2001, "title": "Modulating effects of epithalamin and epithalon on the functional morphology of the spleen in old pinealectomized rats.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1017989113287", "substance": "both", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Khavinson VK", "n_authors": 5, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11865335/", "authors": [ "Khavinson VK", "Konovalov SS", "Yuzhakov VV", "Popuchiev VV", "Kvetnoi IM" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences." ] }, { "pmid": "15926314", "year": 2001, "title": "[Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide livagen].", "journal": "Izvestiia Akademii nauk. Seriia biologicheskaia", "journal_abbr": "Izv Akad Nauk Ser Biol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "in_vitro", "note": "control negativo", "group": "origin_group", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Brodskiĭ VIa", "n_authors": 8, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15926314/", "authors": [ "Brodskiĭ VIa", "Khavinson VKh", "Zolotarev IuA", "Nechaeva NV", "Malinin VV", "Novikova TE", "Gvazava IG", "Fateeva VI" ], "affiliations": [] }, { "pmid": "11928640", "year": 2002, "title": "[Age-related effects in thymocytes differentiation: role of pineal gland peptide factors].", "journal": "Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)", "journal_abbr": "Fiziol Zh (1994)", "language": [ "ukr" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "animal", "note": "", "group": "origin_network", "country": "Ukraine", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Labunets' IF", "n_authors": 1, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/11928640/", "authors": [ "Labunets' IF" ], "affiliations": [ "Institute of Gerontology, AMS of Ukraine." ] }, { "pmid": "12049808", "year": 2002, "title": "Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.", "journal": "Cancer letters", "journal_abbr": "Cancer Lett", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1016/s0304-3835(02)00090-3", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Anisimov VN", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12049808/", "authors": [ "Anisimov VN", "Khavinson VKh", "Popovich IG", "Zabezhinski MA" ], "affiliations": [ "Laboratory of Carcinogenesis and Aging, N.N. Petrov Research Institute of Oncology, 68 Leningradskaya Street, Pesochny-2, 197758, St. Petersburg, Russia. aging@mail.ru" ] }, { "pmid": "12087883", "year": 2002, "title": "[Optimization of cardiovascular function by peptide bio-regulators].", "journal": "Klinicheskaia meditsina", "journal_abbr": "Klin Med (Mosk)", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "human", "note": "cardiovascular", "group": "independent", "country": "Russia", "country_source": "inferred_language", "matched": "epithalamin", "first_author": "Cherkashin VA", "n_authors": 3, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/12087883/", "authors": [ "Cherkashin VA", "Semin GF", "Veretenko AA" ], "affiliations": [] }, { "pmid": "12096440", "year": 2002, "title": "[Aging of the pineal gland].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "both", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Khavinson VKh", "n_authors": 2, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12096440/", "authors": [ "Khavinson VKh", "Golubev AG" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, 3, Dynamo pr., Saint-Petersburg, Russia." ] }, { "pmid": "12096446", "year": 2002, "title": "[Tissue-specific action of peptides in tissue culture of rats of various ages].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Comparative Study", "English Abstract", "Journal Article" ], "doi": null, "substance": "both", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Khavinson VKh", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12096446/", "authors": [ "Khavinson VKh", "Malinin VV", "Chalisova NI", "Grigor'ev EI" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Branch, Russian Academy of Medical Sciences, 3, Dynamo Prospect, 197110 St. Petersburg, Russia." ] }, { "pmid": "12101568", "year": 2002, "title": "[Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice].", "journal": "Voprosy onkologii", "journal_abbr": "Vopr Onkol", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Alimova IN", "n_authors": 9, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12101568/", "authors": [ "Alimova IN", "Bashurin DA", "Popovich IG", "Zabezhinskiĭ MA", "Volkov MA", "Provinciali M", "Franceschi C", "Khavincon BKh", "Anisimov VN" ], "affiliations": [ "N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg." ] }, { "pmid": "12170316", "year": 2002, "title": "Effect of epithalon on age-specific changes in the retina in rats with hereditary pigmentary dystrophy.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1015125031829", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 7, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12170316/", "authors": [ "Khavinson VKh", "Razumovskii MI", "Trofimova SV", "Grigor'yan RA", "Chaban TV", "Oleinik TL", "Razumovskaya AM" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences." ] }, { "pmid": "12195225", "year": 2002, "title": "Aspirin-sensitive asthma due to diffuse neuroendocrine system pathology.", "journal": "Neuro endocrinology letters", "journal_abbr": "Neuro Endocrinol Lett", "language": [ "eng" ], "pub_types": [ "Journal Article", "Review" ], "doi": null, "substance": "epithalamin", "model": "review", "note": "", "group": "independent", "country": "Russia", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Evsyukova HV", "n_authors": 1, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/12195225/", "authors": [ "Evsyukova HV" ], "affiliations": [ "Department of Hospital Therapy, The I.P. Pavlov Medical University, Raevsky st. 7, appt. 7, 194064 St. Petersburg, Russia. ond@aport.ru" ] }, { "pmid": "12195242", "year": 2002, "title": "Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.", "journal": "Neuro endocrinology letters", "journal_abbr": "Neuro Endocrinol Lett", "language": [ "eng" ], "pub_types": [ "Clinical Trial", "Controlled Clinical Trial", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "human", "note": "retinitis pigmentosa + ratas", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson V", "n_authors": 5, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12195242/", "authors": [ "Khavinson V", "Razumovsky M", "Trofimova S", "Grigorian R", "Razumovskaya A" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Branch of the Russian Academy of Medical Sciences, 3 Dynamo Project, 197110 St. Petersburg, Russia. ibg@medport.ru" ] }, { "pmid": "12209581", "year": 2002, "title": "Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.", "journal": "International journal of cancer", "journal_abbr": "Int J Cancer", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1002/ijc.10570", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Anisimov VN", "n_authors": 10, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12209581/", "authors": [ "Anisimov VN", "Khavinson VK", "Provinciali M", "Alimova IN", "Baturin DA", "Popovich IG", "Zabezhinski MA", "Imyanitov EN", "Mancini R", "Franceschi C" ], "affiliations": [ "Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia. aging@mail.ru" ] }, { "pmid": "12360351", "year": 2002, "title": "Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1015899003974", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Rosenfeld SV", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12360351/", "authors": [ "Rosenfeld SV", "Togo EF", "Mikheev VS", "Popovich IG", "Khavinson VKh", "Anisimov VN" ], "affiliations": [ "Department of Medical Biology and Genetics, I. P. Pavlov St. Petersburg State Medical University." ] }, { "pmid": "12360355", "year": 2002, "title": "Effects of epithalon on activities gastrointestinal enzymes in young and old rats.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1015807305791", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 5, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12360355/", "authors": [ "Khavinson VKh", "Malinin VV", "Timofeeva NM", "Egorova VV", "Nikitina AA" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, St. Petersburg. vvm@medport.ru" ] }, { "pmid": "12360356", "year": 2002, "title": "Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1015859322630", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Anisimov SV", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12360356/", "authors": [ "Anisimov SV", "Bokheler KR", "Khavinson VKh", "Anisimov VN" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, St. Petersburg. aging@mail.ru" ] }, { "pmid": "12374906", "year": 2002, "title": "Peptides and Ageing.", "journal": "Neuro endocrinology letters", "journal_abbr": "Neuro Endocrinol Lett", "language": [ "eng" ], "pub_types": [ "Journal Article", "Review" ], "doi": null, "substance": "both", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Khavinson VKh", "n_authors": 1, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12374906/", "authors": [ "Khavinson VKh" ], "affiliations": [ "Saint Petersburg Institute of Bioregulation and Gerontology, 3 Dinamo Pr, Saint Petersburg, 197110, Russia. ibg@medport.ru" ] }, { "pmid": "12420071", "year": 2002, "title": "Effect of Vilon and Epithalon on glucose and glycine absorption in various regions of small intestine in aged rats.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1019878224754", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12420071/", "authors": [ "Khavinson VKh", "Egorova VV", "Timofeeva NM", "Malinin VV", "Gordova LA", "Gromova LV" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-West Department of the Russian Academy of Medical Sciences, St. Petersburg." ] }, { "pmid": "12420072", "year": 2002, "title": "Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1019830308824", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12420072/", "authors": [ "Khavinson VKh", "Rybakina EG", "Malinin VV", "Pivanovich IY", "Shanin SN", "Korneva EA" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences." ] }, { "pmid": "12428286", "year": 2002, "title": "Epithalon inhibits tumor growth and expression of HER-2/neu oncogene in breast tumors in transgenic mice characterized by accelerated aging.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1023/a:1015555023692", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Anisimov VN", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12428286/", "authors": [ "Anisimov VN", "Khavinsov VKh", "Alimova IN", "Provintsiali M", "Manchini R", "Francheski K" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, St. Petersburg. aging@mail.ru" ] }, { "pmid": "12447482", "year": 2002, "title": "In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Comparative Study", "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1023/a:1020210615148", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Kazakova TB", "n_authors": 7, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12447482/", "authors": [ "Kazakova TB", "Barabanova SV", "Khavinson VKh", "Glushikhina MS", "Parkhomenko EP", "Malinin VV", "Korneva EA" ], "affiliations": [ "Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg." ] }, { "pmid": "12459848", "year": 2002, "title": "Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1023/a:1021104819170", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Germany", "country_source": "affiliation", "matched": "epitalon", "first_author": "Anisimov VN", "n_authors": 5, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12459848/", "authors": [ "Anisimov VN", "Khavinson VKh", "Alimova IN", "Semchenko AV", "Yashin AI" ], "affiliations": [ "Max Planck Institute for demographic Research of Society, Rostock, Germany." ] }, { "pmid": "12474803", "year": 2002, "title": "Effects of pineal-gland peptides on the electric activity of pinealocytes in rats.", "journal": "Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections", "journal_abbr": "Dokl Biol Sci", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1019900531675", "substance": "both", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Sibarov DA", "n_authors": 5, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12474803/", "authors": [ "Sibarov DA", "Kovalenko RI", "Nozdrachev AD", "Malinin VV", "Khavinson VKh" ], "affiliations": [ "St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034 Russia." ] }, { "pmid": "12500162", "year": 2002, "title": "Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress.", "journal": "Neuro endocrinology letters", "journal_abbr": "Neuro Endocrinol Lett", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12500162/", "authors": [ "Khavinson VKh", "Korneva EA", "Malinin VV", "Rybakina EG", "Pivanovich IY", "Shanin SN" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Branch of the Russian Academy of Medical Sciences, 12 Acad. Pavlov Street, 197376 St. Petersburg, Russia." ] }, { "pmid": "12500171", "year": 2002, "title": "Epitalon influences pineal secretion in stress-exposed rats in the daytime.", "journal": "Neuro endocrinology letters", "journal_abbr": "Neuro Endocrinol Lett", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "both", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Sibarov DA", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12500171/", "authors": [ "Sibarov DA", "Kovalenko RI", "Malinin VV", "Khavinson VKh" ], "affiliations": [ "Laboratory of Reception Physiology, Acad. I.P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Embankment, 199034 St. Petersburg, Russia. dima@das.stud.pu.ru" ] }, { "pmid": "12577695", "year": 2002, "title": "[Geroprotective effect of thymalin and epithalamin].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article", "Review" ], "doi": null, "substance": "epithalamin", "model": "review", "note": "re-publica cohorte 266", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Khavinson VKh", "n_authors": 2, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12577695/", "authors": [ "Khavinson VKh", "Morozov VG" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, 3, Dynamo Prospect, 197110, St. Petersburg, Russia. khavinson@gerontology.ru" ] }, { "pmid": "12660839", "year": 2002, "title": "Effect of vilon and epithalon on activity of enzymes in epithelial and subepithelial layers in small intestine of old rats.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Comparative Study", "Journal Article" ], "doi": "10.1023/a:1022913228900", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 5, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12660839/", "authors": [ "Khavinson VKh", "Timofeeva NM", "Malinin VV", "Gordova LA", "Nikitina AA" ], "affiliations": [ "Institute of Bioregulation and Gerontology, North-West Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia." ] }, { "pmid": "12608033", "year": 2003, "title": "[Administration of epithalamine in the treatment of unstable glaucoma of different types after normalization of intraocular pressure].", "journal": "Vestnik oftalmologii", "journal_abbr": "Vestn Oftalmol", "language": [ "rus" ], "pub_types": [ "Comparative Study", "English Abstract", "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "human", "note": "28 glaucoma", "group": "independent", "country": "Russia", "country_source": "inferred_language", "matched": "epithalamin", "first_author": "Egorov VV", "n_authors": 3, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12608033/", "authors": [ "Egorov VV", "Sorokin EL", "Smoliakova GP" ], "affiliations": [] }, { "pmid": "12791421", "year": 2003, "title": "The role of pineal gland in breast cancer development.", "journal": "Critical reviews in oncology/hematology", "journal_abbr": "Crit Rev Oncol Hematol", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1016/s1040-8428(03)00021-0", "substance": "both", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Anisimov VN", "n_authors": 1, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12791421/", "authors": [ "Anisimov VN" ], "affiliations": [ "Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Pesochny-2, 197758, St. Petersburg, Russia. aging@mail.ru" ] }, { "pmid": "12809170", "year": 2003, "title": "Effect of a synthetic pineal tetrapeptide (Ala-Glu-Asp-GLy) on melatonin secretion by the pineal gland of young and old rats.", "journal": "Journal of endocrinological investigation", "journal_abbr": "J Endocrinol Invest", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/BF03345159", "substance": "epitalon", "model": "in_vitro", "note": "perifusión pineal rata", "group": "origin_group", "country": "France", "country_source": "affiliation", "matched": "epitalon", "first_author": "Djeridane Y", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12809170/", "authors": [ "Djeridane Y", "Khavinson VKh", "Anisimov VN", "Touitou Y" ], "affiliations": [ "Faculty of Medicine Pitié-Salpêtrière, Medical Biochemistry and Molecular Biology, Paris, France." ] }, { "pmid": "12881997", "year": 2003, "title": "[The study of the role of the water medium in the mechanism of action of peptides in low and ultra low doses].", "journal": "Radiatsionnaia biologiia, radioecologiia", "journal_abbr": "Radiats Biol Radioecol", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "chemistry_analytical", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Grigor'ev EI", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12881997/", "authors": [ "Grigor'ev EI", "Khavinson VKh", "Malinin VV", "Grigor'ev AE", "Kochnev IN", "Kudriavtseva TA" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, 197110 Russia. ibg@medport.ru" ] }, { "pmid": "12910293", "year": 2003, "title": "Retinoprotective effect of Epithalon in campbell rats of various ages.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1024931812822", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 4, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12910293/", "authors": [ "Khavinson VKh", "Razumovsky MI", "Trofimova SV", "Razumovskaya AM" ], "affiliations": [ "St Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences." ] }, { "pmid": "12926216", "year": 2003, "title": "[Effect of epithalamin on free-radical reactions in the formed elements of blood from breast cancer patients].", "journal": "Voprosy onkologii", "journal_abbr": "Vopr Onkol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "in_vitro", "note": "sangre humana", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Sidorenko IuS", "n_authors": 5, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/12926216/", "authors": [ "Sidorenko IuS", "Khavinson VKh", "Vladimirova LIu", "Frantsiiants EM", "Musienko NV" ], "affiliations": [ "Research Institute of Oncology, Rostov-on-Don." ] }, { "pmid": "12937682", "year": 2003, "title": "Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1025493705728", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 3, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12937682/", "authors": [ "Khavinson VKh", "Bondarev IE", "Butyugov AA" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences. ibg@medport.ru" ] }, { "pmid": "12937684", "year": 2003, "title": "Effects of peptides on proliferative activity of retinal and pigmented epithelial cells.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/a:1025497806636", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 4, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12937684/", "authors": [ "Khavinson VKh", "Zemchikhina VN", "Trofimova SV", "Malinin VV" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences, Moscow. ibg4@medport.ru" ] }, { "pmid": "12942748", "year": 2003, "title": "[Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum].", "journal": "Izvestiia Akademii nauk. Seriia biologicheskaia", "journal_abbr": "Izv Akad Nauk Ser Biol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "in_vitro", "note": "suero humano", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Kost NV", "n_authors": 6, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12942748/", "authors": [ "Kost NV", "Sokolov OIu", "Gabaeva MV", "Zolotarev IuA", "Malinin VV", "Khavinson VKh" ], "affiliations": [ "Mental Health Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 34, Moscow, 115522 Russia." ] }, { "pmid": "12964022", "year": 2003, "title": "Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa.", "journal": "International journal of molecular medicine", "journal_abbr": "Int J Mol Med", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Israel", "country_source": "affiliation", "matched": "epitalon", "first_author": "Kossoy G", "n_authors": 9, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/12964022/", "authors": [ "Kossoy G", "Zandbank J", "Tendler E", "Anisimov V", "Khavinson V", "Popovich I", "Zabezhinski M", "Zusman I", "Ben-Hur H" ], "affiliations": [ "Laboratory of Experimental Medicine, Rehovot, Israel." ] }, { "pmid": "14501183", "year": 2003, "title": "Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.", "journal": "Biogerontology", "journal_abbr": "Biogerontology", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1023/a:1025114230714", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Anisimov VN", "n_authors": 9, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/14501183/", "authors": [ "Anisimov VN", "Khavinson VKh", "Popovich IG", "Zabezhinski MA", "Alimova IN", "Rosenfeld SV", "Zavarzina NY", "Semenchenko AV", "Yashin AI" ], "affiliations": [ "Department of Carcinogenesis and Oncogerontology, NN Petrov Research Institute of Oncology, Pesochny-2, St. Petersburg, 197758, Russia. aging@mail.ru" ] }, { "pmid": "14523363", "year": 2003, "title": "Peptides of pineal gland and thymus prolong human life.", "journal": "Neuro endocrinology letters", "journal_abbr": "Neuro Endocrinol Lett", "language": [ "eng" ], "pub_types": [ "Clinical Trial", "Journal Article", "Randomized Controlled Trial" ], "doi": null, "substance": "epithalamin", "model": "human", "note": "266 ancianos 6-8 años", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Khavinson VKh", "n_authors": 2, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/14523363/", "authors": [ "Khavinson VKh", "Morozov VG" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch of the Russian Academy of Medical Sciences, Russia. khavinson@gerontology.ru" ] }, { "pmid": "14571286", "year": 2003, "title": "Gateways to clinical trials.", "journal": "Methods and findings in experimental and clinical pharmacology", "journal_abbr": "Methods Find Exp Clin Pharmacol", "language": [ "eng" ], "pub_types": [ "Bibliography", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "other", "note": "bibliografía", "group": "independent", "country": null, "country_source": null, "matched": "epitalon", "first_author": "Bayés M", "n_authors": 3, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/14571286/", "authors": [ "Bayés M", "Rabasseda X", "Prous JR" ], "affiliations": [ "Prous Science, Barcelona, Spain. mbayes@prous.com" ] }, { "pmid": "14647006", "year": 2003, "title": "Peptide Epitalon activates chromatin at the old age.", "journal": "Neuro endocrinology letters", "journal_abbr": "Neuro Endocrinol Lett", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "in_vitro", "note": "linfocitos humanos", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 7, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/14647006/", "authors": [ "Khavinson VKh", "Lezhava TA", "Monaselidze JR", "Jokhadze TA", "Dvalishvili NA", "Bablishvili NK", "Trofimova SV" ], "affiliations": [ "St Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch of the Russian Academy of Medical Sciences, Russia. khavinson@gerontology.ru" ] }, { "pmid": "14666197", "year": 2003, "title": "Effect of regulatory peptides on gene transcription.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/b:bebm.0000008986.02891.de", "substance": "epitalon", "model": "in_silico", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/14666197/", "authors": [ "Khavinson VKh", "Shataeva LK", "Chernova AA" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences. khavinson@gerontology.ru" ] }, { "pmid": "14743608", "year": 2003, "title": "[Regulating effect of pineal gland peptides on development of T-lymphocytes in CBA aging mice: role of microenvironment of immune system organs and neuroendocrine factors].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "both", "model": "animal", "note": "", "group": "origin_group", "country": "Ukraine", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Labunets IF", "n_authors": 7, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/14743608/", "authors": [ "Labunets IF", "Butenko GM", "Khavinson VKh", "Magdich LV", "Dragunova VA", "Pishel' IN", "Azarskova MV" ], "affiliations": [ "Institute of Gerontology AMS Ukraine 67, Vyshgorodskaya st., Kiev-114, 04114 Ukraine." ] }, { "pmid": "14743609", "year": 2003, "title": "[Peptide correction of age-related pineal disturbances in monkeys].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "both", "model": "animal", "note": "mono", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Goncharova ND", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/14743609/", "authors": [ "Goncharova ND", "Vengerin AA", "Shmaliĭ AV", "Khavinson VKh" ], "affiliations": [ "Institute of Medical Primatology, Russian Academy of Medical Sciences, Veseloye 1, Sochi-Adler, 354376, Russia." ] }, { "pmid": "15085253", "year": 2004, "title": "Effects of short peptides on lymphocyte chromatin in senile subjects.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1023/b:bebm.0000024393.40560.05", "substance": "epitalon", "model": "in_vitro", "note": "linfocitos humanos", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 3, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/15085253/", "authors": [ "Khavinson VKh", "Lezhava TA", "Malinin VV" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences." ] }, { "pmid": "15159690", "year": 2004, "title": "Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.", "journal": "Neuro endocrinology letters", "journal_abbr": "Neuro Endocrinol Lett", "language": [ "eng" ], "pub_types": [ "Comparative Study", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Anisimov SV", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15159690/", "authors": [ "Anisimov SV", "Khavinson VKh", "Anisimov VN" ], "affiliations": [ "Saint-Petersburg Institute of Bioregulation and Gerontology, RAMS, St.-Petersburg, Russia." ] }, { "pmid": "15314861", "year": 2004, "title": "[The use of bioregulator of the cytomedine class--epitalamin--in the treatment of combined craniocerebral trauma].", "journal": "Anesteziologiia i reanimatologiia", "journal_abbr": "Anesteziol Reanimatol", "language": [ "rus" ], "pub_types": [ "Clinical Trial", "Controlled Clinical Trial", "English Abstract", "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "human", "note": "TCE", "group": "independent", "country": "Russia", "country_source": "inferred_language", "matched": "epithalamin", "first_author": "Lebedeva EA", "n_authors": 3, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/15314861/", "authors": [ "Lebedeva EA", "Zavarzina PZh", "Nemkova ZA" ], "affiliations": [] }, { "pmid": "15318714", "year": 2004, "title": "[Optimal conditions for producing immunomodulating effect of epithalamine as component of neoadjuvant chemotherapy using autoplasma and autoblood in patients with locally advanced breast cancer].", "journal": "Voprosy onkologii", "journal_abbr": "Vopr Onkol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "human", "note": "105 cáncer mama", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epithalamin", "first_author": "Zlamnik EIu", "n_authors": 3, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/15318714/", "authors": [ "Zlamnik EIu", "Vladimirova LIu", "Zakora GI" ], "affiliations": [] }, { "pmid": "15452611", "year": 2004, "title": "Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Clinical Trial", "Journal Article", "Randomized Controlled Trial" ], "doi": "10.1023/b:bebm.0000035139.31138.bf", "substance": "epithalamin", "model": "human", "note": "ancianos melatonina", "group": "origin_group", "country": "Ukraine", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Korkushko OV", "n_authors": 4, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15452611/", "authors": [ "Korkushko OV", "Khavinson VKh", "Shatilo VB", "Magdich LV" ], "affiliations": [ "Institute of Gerontology, Academy of Medical Sciences of the Ukraine, Kiev." ] }, { "pmid": "15455093", "year": 2004, "title": "Expression of argyrophilic proteins in the nucleolar organizer regions of human thymocytes and thymic epitheliocytes under conditions of coculturing with vilon and epithalon peptides.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1023/b:bebm.0000042720.40439.16", "substance": "epitalon", "model": "in_vitro", "note": "timocitos humanos", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Raikhlin NT", "n_authors": 10, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/15455093/", "authors": [ "Raikhlin NT", "Bukaeva IA", "Smirnova EA", "Yarilin AA", "Sharova NI", "Mitneva MM", "Khavinson VKh", "Polyakova VO", "Trofimov AV", "Kvetnoi IM" ], "affiliations": [ "N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia." ] }, { "pmid": "15455095", "year": 2004, "title": "Effects of pineal peptides on circadian dynamics of spermatogonia proliferation in albino rats.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/b:bebm.0000042722.66262.de", "substance": "epithalamin", "model": "animal", "note": "", "group": "independent", "country": "Russia", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Arav VI", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15455095/", "authors": [ "Arav VI", "Sych VF", "Zheleznyak EV", "Slesarev SM" ], "affiliations": [ "Department of Common Biology, Ul'yanovsk State University, Russia. bio@ulsu.ru" ] }, { "pmid": "15455129", "year": 2004, "title": "Peptide promotes overcoming of the division limit in human somatic cell.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/b:bebm.0000038164.49947.8c", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 4, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/15455129/", "authors": [ "Khavinson VKh", "Bondarev IE", "Butyugov AA", "Smirnova TD" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and gerontology, North-Western Division of Russian Academy of Medical Sciences." ] }, { "pmid": "15455130", "year": 2004, "title": "Effect of epithalamin on circadian relationship between the endocrine function of the thymus and melatonin-producing function of the pineal gland in elderly people.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/b:bebm.0000038165.09563.b5", "substance": "epithalamin", "model": "human", "note": "ancianos", "group": "origin_group", "country": "Ukraine", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Labunets IF", "n_authors": 6, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/15455130/", "authors": [ "Labunets IF", "Butenko GM", "Magdich LV", "Korkushko OV", "Khavinson VKh", "Shatilo VB" ], "affiliations": [ "Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kiev. admin@geront.kiev.ua" ] }, { "pmid": "15455131", "year": 2004, "title": "Effects of bioactive factors of the pineal gland on thymus function and cell composition of the bone marrow and spleen in mice of different age.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1023/b:bebm.0000038166.54823.06", "substance": "both", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Ukraine", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Labunets IF", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15455131/", "authors": [ "Labunets IF", "Butenko GM", "Khavinson VKh" ], "affiliations": [ "Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kiev. admin@geront.kiev.ua" ] }, { "pmid": "15490729", "year": 2004, "title": "[The pineal gland's peptides factors and the rhythms of functions of the thymus and bone marrow in animals during aging].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "both", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon+epithalamin", "first_author": "Labunets IF", "n_authors": 10, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15490729/", "authors": [ "Labunets IF", "Butenko GM", "Dragunova VA", "Magdich LV", "Kopylova GV", "Rodnichenko AE", "Mikhal'skiĭ SA", "Khavinson VKh", "Azarskova MV", "Maksiuk TV" ], "affiliations": [] }, { "pmid": "15490730", "year": 2004, "title": "[Effect of epitalon on the immunity and hemostasis in hypophysectomized chicken and old hens].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Kuznik BI", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15490730/", "authors": [ "Kuznik BI", "Pateiuk AV", "Khavinson VKh", "Malinin VV" ], "affiliations": [] }, { "pmid": "15501020", "year": 2004, "title": "Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice?", "journal": "Experimental gerontology", "journal_abbr": "Exp Gerontol", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1016/j.exger.2004.08.007", "substance": "epitalon", "model": "animal", "note": "reanálisis", "group": "origin_group", "country": "Germany", "country_source": "affiliation", "matched": "epitalon", "first_author": "Semenchenko GV", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15501020/", "authors": [ "Semenchenko GV", "Anisimov VN", "Yashin AI" ], "affiliations": [ "Max Planck Institute for Demographic Research, Konrad-Zuse-Strasse 1, Rostock D-18057, Germany. semenchenko@demogr.mpg.de" ] }, { "pmid": "15514731", "year": 2004, "title": "Peptide correction of age-related hormonal dysfunction of the pancreas in monkeys.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Comparative Study", "Journal Article" ], "doi": "10.1023/b:bebm.0000046946.25425.f5", "substance": "epitalon", "model": "animal", "note": "mono", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Goncharova ND", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15514731/", "authors": [ "Goncharova ND", "Vengerin AA", "Khavinson VKh", "Lapin BA" ], "affiliations": [ "Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi." ] }, { "pmid": "15559508", "year": 2004, "title": "[The influence of substances revealing geroprotective of spontaneous carcinogenesis in mice].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article", "Review" ], "doi": null, "substance": "epitalon", "model": "review", "note": "", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Popovich IG", "n_authors": 1, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15559508/", "authors": [ "Popovich IG" ], "affiliations": [] }, { "pmid": "15559640", "year": 2004, "title": "[The effect of cytomedines on the hemostatic and antioxidant potential of patients in the early stage of diabetic retinopathy].", "journal": "Eksperimental'naia i klinicheskaia farmakologiia", "journal_abbr": "Eksp Klin Farmakol", "language": [ "rus" ], "pub_types": [ "Evaluation Study", "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "human", "note": "retinopatía diabética", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epithalamin", "first_author": "Gavrilova NA", "n_authors": 5, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/15559640/", "authors": [ "Gavrilova NA", "Fedorova TN", "Trofimova SV", "Pimenov IV", "Lanevskaia NI" ], "affiliations": [] }, { "pmid": "15723138", "year": 2004, "title": "Effect of melatonin and tetrapeptide on gene expression in mouse brain.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't", "Research Support, U.S. Gov't, P.H.S." ], "doi": "10.1007/s10517-005-0082-z", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": null, "country_source": null, "matched": "epitalon", "first_author": "Anisimov SV", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15723138/", "authors": [ "Anisimov SV", "Khavinson VKh", "Anisimov VN" ], "affiliations": [ "Wallenberg Center of Neurology, Lund University, Sweden. aging@mail.ru" ] }, { "pmid": "15664732", "year": 2005, "title": "Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas.", "journal": "Experimental gerontology", "journal_abbr": "Exp Gerontol", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1016/j.exger.2004.10.004", "substance": "both", "model": "animal", "note": "mono", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Goncharova ND", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15664732/", "authors": [ "Goncharova ND", "Vengerin AA", "Khavinson VKh", "Lapin BA" ], "affiliations": [ "Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi-Adler, Veseloye 1, 354376, Russia. iprim@mail.sochi.ru" ] }, { "pmid": "15909815", "year": 2005, "title": "[Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].", "journal": "Voprosy onkologii", "journal_abbr": "Vopr Onkol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Anisimov VN", "n_authors": 7, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15909815/", "authors": [ "Anisimov VN", "Popovich IG", "Zabezhinskiĭ MA", "Rozenfel'd SV", "Khavinson VKh", "Semenchenko AV", "Iashin AI" ], "affiliations": [] }, { "pmid": "15990728", "year": 2005, "title": "DNA double-helix binds regulatory peptides similarly to transcription factors.", "journal": "Neuro endocrinology letters", "journal_abbr": "Neuro Endocrinol Lett", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "chemistry_analytical", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson V", "n_authors": 3, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/15990728/", "authors": [ "Khavinson V", "Shataeva L", "Chernova A" ], "affiliations": [ "St.Petersburg Institute of Bioregulation and Gerontology, North-Western Branch of the Russian Academy of Medical Science, 3, Dynamo Prospect, St-Petersburg, 197110, Russia. khavinson@gerontology.ru" ] }, { "pmid": "16201149", "year": 2005, "title": "[Age-related characteristics of the melatonin-producing epiphyseal function in CBA mice immunized by T-dependent antigen].", "journal": "Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)", "journal_abbr": "Fiziol Zh (1994)", "language": [ "ukr" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "animal", "note": "", "group": "origin_network", "country": "Ukraine", "country_source": "inferred_language", "matched": "epithalamin", "first_author": "Labunets' IF", "n_authors": 1, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/16201149/", "authors": [ "Labunets' IF" ], "affiliations": [] }, { "pmid": "16224563", "year": 2005, "title": "Fluorescent microscopic study of epithalon binding in maternal and fetal rabbit tissues in health and under conditions of placental insufficiency.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng", "rus" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1007/s10517-005-0359-2", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Lapina EA", "n_authors": 11, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/16224563/", "authors": [ "Lapina EA", "Nazarova LA", "Petrova OP", "Sibarov DA", "Zubzhitskaya LB", "Pavlova NG", "Konstantinova NN", "Konovalov YS", "Kvetnoi IM", "Arutyunyan AV", "Grigorev EI" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences. eiisalap@mail.ru" ] }, { "pmid": "16224591", "year": 2005, "title": "Synthesis of IL-2 mRNA in cells of rat hypothalamic structures after injection of short peptides.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Comparative Study", "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1007/s10517-005-0388-x", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Kazakova TB", "n_authors": 7, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/16224591/", "authors": [ "Kazakova TB", "Barabanova SV", "Novikova NS", "Glushikhina MS", "Khavinson VKh", "Malinin VV", "Korneva EA" ], "affiliations": [ "Department of General Pathology and pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Moscow." ] }, { "pmid": "16224593", "year": 2005, "title": "Antigen-induced changes in the endocrine function of the thymus in CBA mice during aging: role of peptide factors released by the pineal gland.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s10517-005-0390-3", "substance": "epithalamin", "model": "animal", "note": "", "group": "origin_network", "country": "Russia", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Labunets IF", "n_authors": 1, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/16224593/", "authors": [ "Labunets IF" ], "affiliations": [ "Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kiev, Moscow. admin@geront.kiev.ua" ] }, { "pmid": "16634527", "year": 2006, "title": "Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.", "journal": "In vivo (Athens, Greece)", "journal_abbr": "In Vivo", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Israel", "country_source": "affiliation", "matched": "epitalon", "first_author": "Kossoy G", "n_authors": 5, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/16634527/", "authors": [ "Kossoy G", "Anisimov VN", "Ben-Hur H", "Kossoy N", "Zusman I" ], "affiliations": [ "Koret School of Veterinary Medicine, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel." ] }, { "pmid": "16705247", "year": 2006, "title": "Anti-aging peptide bioregulators induce reactivation of chromatin.", "journal": "Georgian medical news", "journal_abbr": "Georgian Med News", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "in_vitro", "note": "linfocitos humanos", "group": "origin_network", "country": "Georgia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Lezhava T", "n_authors": 5, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/16705247/", "authors": [ "Lezhava T", "Monaselidze J", "Kadotani T", "Dvalishvili N", "Buadze T" ], "affiliations": [ "Tbilisi State University." ] }, { "pmid": "17002046", "year": 2006, "title": "[Effects of melatonin and epitalone on antioxidant system of rats depends on light conditions].", "journal": "Patologicheskaia fiziologiia i eksperimental'naia terapiia", "journal_abbr": "Patol Fiziol Eksp Ter", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Vinogradova IA", "n_authors": 5, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/17002046/", "authors": [ "Vinogradova IA", "Iliukha VA", "Il'ina TN", "Uzenbaeva LB", "Fedorova AS" ], "affiliations": [] }, { "pmid": "17152351", "year": 2006, "title": "Interleukin-2 concentration in hypothalamic structures of rats receiving peptides during mild stress.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1007/s10517-006-0179-z", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Barabanova SV", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/17152351/", "authors": [ "Barabanova SV", "Artyukhina ZE", "Kazakova TB", "Khavinson VKh", "Malinin VV", "Korneva EA" ], "affiliations": [ "Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg." ] }, { "pmid": "17152370", "year": 2006, "title": "Molecular mechanism of interaction between oligopeptides and double-stranded DNA.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s10517-006-0198-9", "substance": "epitalon", "model": "chemistry_analytical", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 3, "mesh_humans": false, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/17152370/", "authors": [ "Khavinson VKh", "Solovyov AY", "Shataeva LK" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences." ] }, { "pmid": "17152723", "year": 2006, "title": "[Influence of light regimens, melatonin, and epitalon on amylase activity in the pancreas and small intestine in rats of different age].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Svechkina EB", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/17152723/", "authors": [ "Svechkina EB", "Tiutiunnik NN", "Vinogradova IA" ], "affiliations": [] }, { "pmid": "17152724", "year": 2006, "title": "[Effect of age, different light conditions, melatonin, and epitalon on lysosomal proteinase activity in the liver and kidneys of rats].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": 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[] }, { "pmid": "17217245", "year": 2006, "title": "[Intranasal epitalon infusion modulates neuronal activity in the rat neocortex].", "journal": "Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova", "journal_abbr": "Ross Fiziol Zh Im I M Sechenova", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Sibarov DA", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/17217245/", "authors": [ "Sibarov DA", "Vol'nova AB", "Frolov DS", "Nosdrachev AD" ], "affiliations": [] }, { "pmid": "17426848", "year": 2006, "title": "Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng", "rus" ], "pub_types": [ "Journal Article", "Randomized Controlled Trial" ], "doi": "10.1007/s10517-006-0365-z", "substance": "epithalamin", "model": "human", "note": "ECA 12 años", "group": "origin_group", "country": "Ukraine", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Korkushko OV", "n_authors": 4, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/17426848/", "authors": [ "Korkushko OV", "Khavinson VKh", "Shatilo VB", "Antonyuk-Shcheglova IA" ], "affiliations": [ "Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kiev." ] }, { "pmid": "17426849", "year": 2006, "title": "Production of lymphocyte-activating factors by mouse macrophages during aging and under the effect of short peptides.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng", "rus" ], "pub_types": [ "Comparative Study", "Journal Article" ], "doi": "10.1007/s10517-006-0366-y", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Gumen AV", "n_authors": 5, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/17426849/", "authors": [ "Gumen AV", "Kozinets IA", "Shanin SN", "Malinin VV", "Rybakina EG" ], "affiliations": [ "Laboratory of Peptide Pharmacology, St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences." ] }, { "pmid": "17317455", "year": 2007, "title": "Antioxidant properties of geroprotective peptides of the pineal gland.", "journal": "Archives of gerontology and geriatrics", "journal_abbr": "Arch Gerontol Geriatr", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1016/j.archger.2007.01.029", "substance": "both", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Kozina LS", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/17317455/", "authors": [ "Kozina LS", "Arutjunyan AV", "Khavinson VKh" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch of the Russian Academy of Medical Sciences, 197110 St. Petersburg, Russia. lucagramaglia@email.it " ] }, { "pmid": "17461018", "year": 2007, "title": "[Parallel analysis of c-Fos protein and interleukin-2 expression in hypothalamic cells under different influence].", "journal": "Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova", "journal_abbr": "Ross Fiziol Zh Im I M Sechenova", "language": [ "rus" ], "pub_types": [ "Comparative Study", "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Barabanova SV", "n_authors": 8, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/17461018/", "authors": [ "Barabanova SV", "Artiukhina ZE", "Ovchinnikova KT", "Abramova TV", "Kazakova TB", "Khavinson VKh", "Malinin VV", "Korneva EA" ], "affiliations": [] }, { "pmid": "17955380", "year": 2007, "title": "Effects of intranasal administration of epitalon on neuron activity in the rat neocortex.", "journal": "Neuroscience and behavioral physiology", "journal_abbr": "Neurosci Behav Physiol", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1007/s11055-007-0095-3", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_network", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Sibarov DA", "n_authors": 4, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/17955380/", "authors": [ "Sibarov DA", "Vol'nova AB", "Frolov DS", "Nozdrachev AD" ], "affiliations": [ "Reception Physiology Laboratory, I. 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Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St. Petersburg, Russia." ] }, { "pmid": "17969589", "year": 2007, "title": "[Age-related changes of exercise capacity and some biochemical indices of rat muscles under influence of different light conditions and pineal preparations].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Vingradova IA", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/17969589/", "authors": [ "Vingradova IA", "Iliukha VA", "Fedorova AS", "Khizhkin EA", "Unzhakov AR", "Iunash VD" ], "affiliations": [] }, { "pmid": "17969590", "year": 2007, "title": "[Normalizing 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biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s10517-007-0159-y", "substance": "epithalamin", "model": "human", "note": "coronarios", "group": "origin_network", "country": "Ukraine", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Labunets IF", "n_authors": 4, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/18214303/", "authors": [ "Labunets IF", "Butenko GM", "Korkushko OV", "Shatilo VB" ], "affiliations": [ "Institute of Gerontology, Academy of Medical Sciences of the Ukraine, Kiev. admin@geront.kiev.ua" ] }, { "pmid": "18239817", "year": 2007, "title": "Effects of bioactive tetrapeptides on free-radical processes.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng", "rus" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s10517-007-0230-8", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Kozina LS", "n_authors": 1, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/18239817/", "authors": [ "Kozina LS" ], "affiliations": [ "St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences. milarozina@mail.ru" ] }, { "pmid": "18306696", "year": 2007, "title": "[Effect of pineal gland peptides on morphofunctional structure of the pancreas in ageing].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "both", "model": "animal", "note": "", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon+epithalamin", "first_author": "Ryzhak AP", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/18306696/", "authors": [ "Ryzhak AP", "Kostiuchek IN", "Kvetnoĭ IM" ], "affiliations": [] }, { "pmid": "18309632", "year": 2007, "title": "[Circannual rhythms of bone marrow cell composition in animals during aging: the role of pineal factors].", "journal": "Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)", "journal_abbr": "Fiziol Zh (1994)", "language": [ "ukr" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "both", "model": "animal", "note": "", "group": "origin_network", "country": "Ukraine", "country_source": "inferred_language", "matched": "epitalon+epithalamin", "first_author": "Labunets' IF", "n_authors": 1, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/18309632/", "authors": [ "Labunets' IF" ], "affiliations": [] }, { "pmid": "18383712", "year": 2007, "title": "[The effect of pineal peptide preparations on proliferative activity in organotypic culture of the preoptic hypothalamus area].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "both", "model": "in_vitro", "note": "", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon+epithalamin", "first_author": "Miliutina IuP", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/18383712/", "authors": [ "Miliutina IuP", "Kozina LS", "Arutiunian AV", "Chalisova NI", "Lesniak VV", "Morozova PIu" ], "affiliations": [] }, { "pmid": "18856211", "year": 2007, "title": "Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1007/s10517-007-0441-z", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Vinogradova IA", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/18856211/", "authors": [ "Vinogradova IA", "Bukalev AV", "Zabezhinski MA", "Semenchenko AV", "Khavinson VKh", "Anisimov VN" ], "affiliations": [ "Petrozavodsk State University, St Petersburg." ] }, { "pmid": "18264770", "year": 2008, "title": "Comparative analysis of the expression of c-Fos and interleukin-2 proteins in hypothalamus cells during various treatments.", "journal": "Neuroscience and behavioral physiology", "journal_abbr": "Neurosci Behav Physiol", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, 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"epitalon", "model": "animal", "note": "", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Kozina LS", "n_authors": 1, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/18546825/", "authors": [ "Kozina LS" ], "affiliations": [] }, { "pmid": "18546826", "year": 2008, "title": "[Biological activity of regulatory peptides in model experiments in vitro].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Kozina LS", "n_authors": 4, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/18546826/", "authors": [ "Kozina LS", "Arutiunian AV", "Stvolinskiĭ SL", "Khavinson VKh" ], "affiliations": [] }, { "pmid": "18546838", "year": 2008, "title": "[Effect of the pineal gland peptide preparation on the diurnal profile of arterial pressure in middle-aged and elderly women with ischemic heart disease and arterial hypertension].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article", "Randomized Controlled Trial" ], "doi": null, "substance": "epithalamin", "model": "human", "note": "ECA mujeres CI/HTA", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epithalamin", "first_author": "Merkur'eva GA", "n_authors": 2, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/18546838/", "authors": [ "Merkur'eva GA", "Ryzhak GA" ], "affiliations": [] }, { "pmid": "18830022", "year": 2008, "title": "[The effect of heavy metal ions and peptide bioregulators on the expression of chromosome fragile sites in the individuals of different age groups and breast cancer patients].", "journal": "Georgian medical news", "journal_abbr": "Georgian Med News", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article" ], "doi": null, "substance": "epitalon", "model": "in_vitro", "note": "linfocitos humanos", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Dzhokhadze TA", "n_authors": 3, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/18830022/", "authors": [ "Dzhokhadze TA", "Ganozishvili MN", "Lezhava TA" ], "affiliations": [] }, { "pmid": "19024016", "year": 2008, "title": "Effect of tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the structure and function of the thyroid gland in neonatally hypophysectomized chickens.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s10517-008-0033-6", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_network", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Kuznik BI", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/19024016/", "authors": [ "Kuznik BI", "Pateyuk AV", "Rusaeva NS" ], "affiliations": [ "Department of Normal Physiology, Department of Histology, Chita State Medical Academy. bi_kuznik@mail.ru" ] }, { "pmid": "19110597", "year": 2008, "title": "Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Evaluation Study", "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1007/s10517-008-0121-7", 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"doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_network", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Uzenbaeva LB", "n_authors": 5, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/19432172/", "authors": [ "Uzenbaeva LB", "Vinogradova IA", "Golubeva AG", "Niuppieva MG", "Iliukha VA" ], "affiliations": [] }, { "pmid": "19526107", "year": 2008, "title": "Melting of DNA double strand after binding to geroprotective tetrapeptide.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s10517-009-0342-4", "substance": "epitalon", "model": "chemistry_analytical", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 3, "mesh_humans": false, 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Wytsmansstraat14, B-1050, Brussels, Belgium." ] }, { "pmid": "25841380", "year": 2015, "title": "The interaction of amino acids, peptides, and proteins with DNA.", "journal": "International journal of biological macromolecules", "journal_abbr": "Int J Biol Macromol", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1016/j.ijbiomac.2015.03.054", "substance": "epitalon", "model": "chemistry_analytical", "note": "", "group": "origin_network", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Solovyev AY", "n_authors": 5, "mesh_humans": false, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/25841380/", "authors": [ "Solovyev AY", "Tarnovskaya SI", "Chernova IA", "Shataeva LK", "Skorik YA" ], "affiliations": [ "Institute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoy pr. VO 31, St. Petersburg 199004, Russian Federation.", "Institute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoy pr. VO 31, St. Petersburg 199004, Russian Federation; St. Petersburg State Chemical Pharmaceutical Academy, ul. Prof. Popova 14, St. Petersburg 197022, Russian Federation. Electronic address: yury_skorik@mail.ru.", "St. Petersburg State Polytechnical University, Polytekhnicheskaya ul. 29, St. Petersburg 195251, Russian Federation." ] }, { "pmid": "26515176", "year": 2015, "title": "Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s10517-015-3062-y", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Ukraine", "country_source": "affiliation", "matched": "epitalon", "first_author": "Zamorskii II", "n_authors": 5, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/26515176/", "authors": [ "Zamorskii II", "Shchudrova TS", "Lin'kova NS", "Nichik TE", "Khavinson VKh" ], "affiliations": [ "Bukovinian State Medical University, Chernovtsy, Ukraine.", "Bukovinian State Medical University, Chernovtsy, Ukraine. tshchudrova@gmail.com.", "I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russia.", "St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.", "St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. linkova@gerontology.ru.", "St. Petersburg State Polytechnic University, St. Petersburg, Russia.", "St. Petersburg State Polytechnic University, St. Petersburg, Russia. linkova@gerontology.ru." ] }, { "pmid": "26519279", "year": 2015, "title": "Effects of Geroprotectors on Age-Related Changes in Proteolytic Digestive Enzyme Activities at Different Lighting Conditions.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1007/s10517-015-3069-4", "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Morozov AV", "n_authors": 7, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/26519279/", "authors": [ "Morozov AV", "Khizhkin EA", "Svechkina EB", "Vinogradova IA", "Ilyukha VA", "Anisimov VN", "Khavinson VKh" ], "affiliations": [ "Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia.", "Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia. artem.morozow@yandex.ru.", "N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia.", "Petrozavodsk State University, Petrozavodsk, Republic of Karelia.", "St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia." ] }, { "pmid": "26593924", "year": 2015, "title": "An Efficient Data-Gathering Routing Protocol for Underwater Wireless Sensor Networks.", "journal": "Sensors (Basel, Switzerland)", "journal_abbr": "Sensors (Basel)", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.3390/s151129149", "substance": "false_positive", "model": "other", "note": "redes de sensores", "group": null, "country": null, "country_source": null, "matched": "epitalon", "first_author": "Javaid N", "n_authors": 8, "mesh_humans": false, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/26593924/", "authors": [ "Javaid N", "Ilyas N", "Ahmad A", "Alrajeh N", "Qasim U", "Khan ZA", "Liaqat T", "Khan MI" ], "affiliations": [ "COMSATS Institute of Information Technology, Park Road, Islamabad 44000, Pakistan. ashfaqcomsats@gmail.com.", "COMSATS Institute of Information Technology, Park Road, Islamabad 44000, Pakistan. majid_iqbal@comsats.edu.pk.", "COMSATS Institute of Information Technology, Park Road, Islamabad 44000, Pakistan. nadeemjavaidqau@gmail.com.", "COMSATS Institute of Information Technology, Park Road, Islamabad 44000, Pakistan. naveedilyas.ajk@gmail.com.", "Cameron Library, University of Alberta, Edmonton, AB T6G 2J8, Canada. umar.qasim@ualberta.ca.", "College of Applied Medical Sciences, Department of Biomedical Technology, King Saud University, Riyadh 11633, Saudi Arabia. nabil@ksu.edu.sa.", "Institute of Space Technology, Islamabad Highway, Islamabad 44000, Pakistan. tayyaba.bet091@gmail.com.", "Internetworking Program, FE, Dalhousie University, Halifax, NS B3J 4R2, Canada. zahoor.khan@dal.ca." ] }, { "pmid": "27183783", "year": 2015, "title": "[The Role of Cytokines MIC-1/GDF15 in Development of the Old Age Disease].", "journal": "Uspekhi fiziologicheskikh nauk", "journal_abbr": "Usp Fiziol Nauk", "language": [ "rus" ], "pub_types": [ "English Abstract", "Journal Article", "Review" ], "doi": null, "substance": "epitalon", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "inferred_language", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 4, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/27183783/", "authors": [ "Khavinson VKh", "Kuznik BI", "Linkova NS", "Kolchina NV" ], "affiliations": [] }, { "pmid": "28509452", "year": 2015, "title": "[Adhesion molecule JAM-A, its function and mechanism of epigenetic regulation].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Journal Article", "Review" ], "doi": null, "substance": "epitalon", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Kuznik BI", "n_authors": 6, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/28509452/", "authors": [ "Kuznik BI", "Khavinson VK", "Tarnovskaya SI", "Linkova NS", "Kozina LS", "Dyakonov MM" ], "affiliations": [ "Chita State Medical Academy, Chita, 672000, Russian Federation.", "I. I. Mechnikov North-Western State Medical University, Saint-Petersburg, 193015, Russian Federation.", "I. P. Pavlov Institute of Physiology of RAS, Saint-Petersburg, 199034, Russian Federation.", "Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation.", "Saint-Petersburg State Polytechnic University, Saint-Petersburg, 195251, Russian Federation; miayy@yandex.ru." ] }, { "pmid": "26742748", "year": 2016, "title": "Short Peptides and Telomere Length Regulator Hormone Irisin.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s10517-016-3167-y", "substance": "epitalon", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VKh", "n_authors": 4, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/26742748/", "authors": [ "Khavinson VKh", "Kuznik BI", "Tarnovskaya SI", "Lin'kova NS" ], "affiliations": [ "Chita State Medical Academy, Ministry of Health of the Russian Federation, Chita, Russia.", "Russian Academy of Sciences, I. P. Pavlov Institute of Physiology, Moskva, Russia.", "St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.", "St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. linkova@gerontology.ru.", "St. Petersburg State Polytechnological University, St. Petersburg, Russia.", "St. Petersburg State Polytechnological University, St. Petersburg, Russia. linkova@gerontology.ru." ] }, { "pmid": "27259496", "year": 2016, "title": "Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s10517-016-3370-x", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Lin'kova NS", "n_authors": 7, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/27259496/", "authors": [ "Lin'kova NS", "Drobintseva AO", "Orlova OA", "Kuznetsova EP", "Polyakova VO", "Kvetnoy IM", "Khavinson VKh" ], "affiliations": [ "D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia.", "I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russia.", "I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.", "I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. miayy@yandex.ru.", "Peter the Great St. Petersburg Polytechnical University, St. Petersburg, Russia.", "Peter the Great St. Petersburg Polytechnical University, St. Petersburg, Russia. miayy@yandex.ru.", "St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.", "St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. miayy@yandex.ru." ] }, { "pmid": "27339321", "year": 2016, "title": "Characterization of OsLEA1a and its inhibitory effect on the resistance of E. coli to diverse abiotic stresses.", "journal": "International journal of biological macromolecules", "journal_abbr": "Int J Biol Macromol", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1016/j.ijbiomac.2016.06.056", "substance": "false_positive", "model": "other", "note": "proteína vegetal", "group": null, "country": null, "country_source": null, "matched": "epitalon", "first_author": "Hu T", "n_authors": 5, "mesh_humans": false, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/27339321/", "authors": [ "Hu T", "Zhou N", "Fu M", "Qin J", "Huang X" ], "affiliations": [ "Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Bioengineering College of Chongqing University, Chongqing 400030, China.", "Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Bioengineering College of Chongqing University, Chongqing 400030, China; School of Life Science and Engineering, Chongqing Three Gorges University, Chongqing 404100, China. Electronic address: tzhu2002@foxmail.com.", "School of Life Science and Engineering, Chongqing Three Gorges University, Chongqing 404100, China." ] }, { "pmid": "27589750", "year": 2016, "title": "On Reliable and Efficient Data Gathering Based Routing in Underwater Wireless Sensor Networks.", "journal": "Sensors (Basel, Switzerland)", "journal_abbr": "Sensors (Basel)", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.3390/s16091391", "substance": "false_positive", "model": "other", "note": "redes de sensores", "group": null, "country": null, "country_source": null, "matched": "epitalon", "first_author": "Liaqat T", "n_authors": 8, "mesh_humans": false, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/27589750/", "authors": [ "Liaqat T", "Akbar M", "Javaid N", "Qasim U", "Khan ZA", "Javaid Q", "Alghamdi TA", "Niaz IA" ], "affiliations": [ "COMSATS Institute of Information Technology, Park Road, Islamabad 44000, Pakistan. ianiaz@comsats.edu.pk.", "COMSATS Institute of Information Technology, Park Road, Islamabad 44000, Pakistan. mariam.akbar@gmail.com.", "COMSATS Institute of Information Technology, Park Road, Islamabad 44000, Pakistan. nadeemjavaidqau@gmail.com.", "Cameron Library, University of Alberta, Edmonton, AB T6G 2J8, Canada. umar.qasim@ualberta.ca.", "College of CIS, Umm AlQura University, Makkah 11692, Saudi Arabia. ta_ghamdi@hotmail.com.", "Institute of Space Technology, Islamabad 44000, Pakistan. tayyaba.bet091@gmail.com.", "International Islamic University, Islamabad 44000, Pakistan. qaisar@iiu.edu.pk.", "Internetworking Program, FE, Dalhousie University, Halifax, NS B3J 4R2, Canada. zahoor.khan@dal.ca." ] }, { "pmid": "28252435", "year": 2017, "title": "[GENOMIC VARIABILITY IN PATIENTS WITH DUCTAL FORM OF BREAST CANCER AND THE POSSIBILITY OF CORRECTION THE PEPTIDE BIOREGULATOR AND METAL IONS].", "journal": "Georgian medical news", "journal_abbr": "Georgian Med News", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "in_vitro", "note": "linfocitos humanos", "group": "origin_network", "country": "Georgia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Jokhadze T", "n_authors": 6, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/28252435/", "authors": [ "Jokhadze T", "Monaselidze J", "Nemsadze G", "Buadze T", "Gaiozishvili M", "Lezhava T" ], "affiliations": [ "Iv. Javakhishvili Tbilisi State University, Department of Genetics, Tbilisi, Georgia; Department of Physics of Biological Systems. E. Andronikashvili Institute of Physics, Tbilisi, Georgia.", "Iv. Javakhishvili Tbilisi State University, Department of Genetics, Tbilisi, Georgia; Department of Physics of Biological Systems. E. Andronikashvili Institute of Physics, Tbilisi, Georgia; K. Madichi Centre of Oncology, Tbilisi, Georgia." ] }, { "pmid": "28371610", "year": 2017, "title": "Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum.", "journal": "Biochemistry. Biokhimiia", "journal_abbr": "Biochemistry (Mosc)", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1134/S0006297917040149", "substance": "epitalon", "model": "in_vitro", "note": "planta (tabaco)", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Fedoreyeva LI", "n_authors": 7, "mesh_humans": false, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/28371610/", "authors": [ "Fedoreyeva LI", "Dilovarova TA", "Ashapkin VV", "Martirosyan YT", "Khavinson VK", "Kharchenko PN", "Vanyushin BF" ], "affiliations": [ "All-Russia Research Institute of Agricultural Biotechnology, Russian Academy of Sciences, Moscow, 127550, Russia. vanyush@belozersky.msu.ru." ] }, { "pmid": "28849889", "year": 2017, "title": "[Pineamin increased pineal melatonin synthesis in elderly people].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "other_pineal_extract", "model": "human", "note": "Pineamin 55 ancianos", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Trofimova SV", "n_authors": 5, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/28849889/", "authors": [ "Trofimova SV", "Linkova NS", "Klimenko AA", "Kvetnaia TV", "Khavinson VK" ], "affiliations": [ "Group of companies «Geropharm», Degtyarnyj lane, 11B, St. Petersburg, 191144, Russian Federation.", "Pavlov Institute of Physiology of RAS, Makarova emb., St. Petersburg, 6199034, Russian Federation.", "Peter the Great Saint-Petersburg Polytechnic University, 29, Polytechnicheskaya str., St. Petersburg, 195251, Russian Federation.", "Saint-Petersburg Institute of Bioregulation and Gerontology, 3, Dynamo pr., St. Petersburg, 197110, Russian Federation; linkova@gerontology.ru." ] }, { "pmid": "28948547", "year": 2017, "title": "Peptides (Epigenetic Regulators) in the Structure of Rodents with a Long and Short Lifespan.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s10517-017-3876-x", "substance": "epitalon", "model": "in_silico", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VK", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/28948547/", "authors": [ "Khavinson VK", "Kormilets DY", "Mar'yanovich AT" ], "affiliations": [ "I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russia.", "I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russia. atm52@mail.ru.", "S. M. Kirov Military Medical Academy, St. Petersburg, Russia.", "St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia." ] }, { "pmid": "29124531", "year": 2017, "title": "Identification of Peptide AEDG in the Polypeptide Complex of the Pineal Gland.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s10517-017-3922-8", "substance": "epitalon", "model": "chemistry_analytical", "note": "identificación en complejo pineal", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VK", "n_authors": 5, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/29124531/", "authors": [ "Khavinson VK", "Kopylov AT", "Vaskovsky BV", "Ryzhak GA", "Lin'kova NS" ], "affiliations": [ "I. P. Pavlov Institute of Physiology of Russian Academy of Sciences, St. Petersburg, Russia. khavinson@gerontology.ru.", "Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia.", "Research Centre St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.", "Research Centre St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. khavinson@gerontology.ru." ] }, { "pmid": "30607912", "year": 2018, "title": "[The influence of peptides on the morphofunctional state of old rats kidneys.].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "animal", "note": "", "group": "origin_group", "country": "Ukraine", "country_source": "affiliation", "matched": "epitalon", "first_author": "Zamorskii II", "n_authors": 6, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/30607912/", "authors": [ "Zamorskii II", "Shchudrova TS", "Zeleniuk VG", "Linkova NS", "Nichik TE", "Khavinson VK" ], "affiliations": [ "Bukovinian State Medical University, 2, Teatralnaia sq., Chernovtsy, 58002, Ukraine; e-mail: igor.zamorskii@gmail.com.", "I.P.Pavlov Institute of Physiology, RAS, 6, Makarova Emb., St. Petersburg, 199034, Russian Federation.", "Peter the Great Saint Petersburg Polytechnic University, 29, Polytechnicheskaya str., St. Petersburg, 195251, Russian Federation.", "Saint-Petersburg Institute of Bioregulation and Gerontology, 3, pr. Dinamo, St. Petersburg, 197110, Russian Federation; e-mail: khavinson@gerontology.ru." ] }, { "pmid": "30791821", "year": 2019, "title": "Effect of short peptides on neuronal differentiation of stem cells.", "journal": "International journal of immunopathology and pharmacology", "journal_abbr": "Int J Immunopathol Pharmacol", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1177/2058738419828613", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Italy", "country_source": "affiliation", "matched": "epitalon", "first_author": "Caputi S", "n_authors": 8, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/30791821/", "authors": [ "Caputi S", "Trubiani O", "Sinjari B", "Trofimova S", "Diomede F", "Linkova N", "Diatlova A", "Khavinson V" ], "affiliations": [ "1 Laboratory of Stem Cells and Regenerative Medicine, Department of Medical, Oral and Biotechnological Sciences, School of Medicine and Health Sciences, University \"G. d'Annunzio\" Chieti-Pescara, Chieti, Italy.", "2 Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg, Russia.", "3 Department of Medical Physic, Peter the Great St. Petersburg Polytechnic University, Saint Petersburg, Russia.", "4 Group of Peptide Regulation of Ageing, Pavlov Institute of Physiology of RAS, Saint Petersburg, Russia." ] }, { "pmid": "31761987", "year": 2019, "title": "Effect of Peptide AEDG on Telomere Length and Mitotic Index of PHA-Stimulated Human Blood Lymphocytes.", "journal": "Bulletin of experimental biology and medicine", "journal_abbr": "Bull Exp Biol Med", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s10517-019-04664-0", "substance": "epitalon", "model": "in_vitro", "note": "linfocitos humanos n=11", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VK", "n_authors": 10, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/31761987/", "authors": [ "Khavinson VK", "Pendina AA", "Efimova OA", "Tikhonov AV", "Koltsova AS", "Krapivin MI", "Petrovskaia-Kaminskaia AV", "Petrova LI", "Lin'kova NS", "Baranov VS" ], "affiliations": [ "Department of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, Moscow, Russia.", "Department of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, Moscow, Russia. miayy@yandex.ru.", "Department of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia.", "Department of Therapy, Geriatry, and Anti-Aging Medicine, Academy of Postgraduate Education, Federal Research Clinical Center, Federal Medical-Biological Agency of Russia, Moscow, Russia. miayy@yandex.ru." ] }, { "pmid": "31677028", "year": 2020, "title": "Short Peptides Protect Oral Stem Cells from Ageing.", "journal": "Stem cell reviews and reports", "journal_abbr": "Stem Cell Rev Rep", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1007/s12015-019-09921-3", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Sinjari B", "n_authors": 8, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/31677028/", "authors": [ "Sinjari B", "Diomede F", "Khavinson V", "Mironova E", "Linkova N", "Trofimova S", "Trubiani O", "Caputi S" ], "affiliations": [ "Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.", "Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. miayy@yandex.ru.", "Department of Geriatrics, Propaedeutics and Nursing Management, Mechnikov North-Western State Medical University, St. Petersburg, Russia.", "Department of Medical, Oral and Biotechnological Sciences, University \"G. d'Annunzio\" Chieti-Pescara, Chieti, Italy.", "Department of Therapy, Geriatrics, and Anti-Aging Medicine, Academy of Postgraduate Education, Moscow, Russia.", "Department of Therapy, Geriatrics, and Anti-Aging Medicine, Academy of Postgraduate Education, Moscow, Russia. miayy@yandex.ru.", "Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia." ] }, { "pmid": "31808038", "year": 2020, "title": "Peptide Regulation of Cell Differentiation.", "journal": "Stem cell reviews and reports", "journal_abbr": "Stem Cell Rev Rep", "language": [ "eng" ], "pub_types": [ "Journal Article", "Review" ], "doi": "10.1007/s12015-019-09938-8", "substance": "epitalon", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson V", "n_authors": 4, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/31808038/", "authors": [ "Khavinson V", "Linkova N", "Diatlova A", "Trofimova S" ], "affiliations": [ "Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.", "Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. miayy@yandex.ru.", "Department of Geriatrics, Propaedeutics and Nursing Management, Mechnikov North-Western State Medical University, St. Petersburg, Russia.", "Department of Therapy, Geriatrics, and Anti-Aging Medicine, Academy of Postgraduate Education, Moscow, Russia.", "Department of Therapy, Geriatrics, and Anti-Aging Medicine, Academy of Postgraduate Education, Moscow, Russia. miayy@yandex.ru.", "Group of Peptide Regulation of Ageing, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia." ] }, { "pmid": "32019204", "year": 2020, "title": "AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.", "journal": "Molecules (Basel, Switzerland)", "journal_abbr": "Molecules", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.3390/molecules25030609", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson V", "n_authors": 8, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/32019204/", "authors": [ "Khavinson V", "Diomede F", "Mironova E", "Linkova N", "Trofimova S", "Trubiani O", "Caputi S", "Sinjari B" ], "affiliations": [ "Academy of postgraduate education under FSBU FSCC of FMBA of Russia, Volokolamskaya r., 91, 125371 Moscow, Russia.", "Pavlov Institute of Physiology Russian Academy of Sciences, Makarova Emb., 6, 199034 St. Petersburg, Russia.", "Saint Petersburg Institute of Bioregulation and Gerontology, Dynamo Ave., 3, 197110 St. Petersburg, Russia.", "University \"G. d'Annunzio\" Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy." ] }, { "pmid": "32362083", "year": 2020, "title": "[Short peptides: regulation of skin function during aging.].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VK", "n_authors": 5, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/32362083/", "authors": [ "Khavinson VK", "Linkova NS", "Diatlova AS", "Gutop EO", "Orlova OA" ], "affiliations": [ "Academy of Postgraduate Education, 91 Volokolamskoe shosse, Moscow 125371, Russian Federation.", "I.P.Pavlov Institute of Physiology, 6 Makarova emb., St. Petersburg 199034, Russian Federation.", "Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dinamo, St. Petersburg 197110, Russian Federation, e-mail: miayy@yandex.ru." ] }, { "pmid": "32362097", "year": 2020, "title": "[Age features of bioregulatory therapy of dental diseases.].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epithalamin", "model": "review", "note": "", "group": "origin_network", "country": "Russia", "country_source": "affiliation", "matched": "epithalamin", "first_author": "Pinelis IS", "n_authors": 5, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/32362097/", "authors": [ "Pinelis IS", "Pinelis YI", "Kuznik BI", "Iordanishvili AK", "Vasiliev MA" ], "affiliations": [ "Chita State Academy of Medicine, 39A str. Gorky, Chita 672000, Russian Federation, e-mail: pochta@chitgma.ru.", "I.I.Mechnikov North-West State Medical University, 14 bldg. 3 Marshala Kazakova str., St. Petersburg 198302, Russian Federation, e-mail: professoraki@mail.ru.", "S.M. Kirov Military Medical Academy, 6 Acad. Lebedeva str., Saint Petersburg 194044, Russian Federation." ] }, { "pmid": "32987757", "year": 2020, "title": "Peptides: Prospects for Use in the Treatment of COVID-19.", "journal": "Molecules (Basel, Switzerland)", "journal_abbr": "Molecules", "language": [ "eng" ], "pub_types": [ "Journal Article", "Review" ], "doi": "10.3390/molecules25194389", "substance": "epitalon", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson V", "n_authors": 5, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/32987757/", "authors": [ "Khavinson V", "Linkova N", "Dyatlova A", "Kuznik B", "Umnov R" ], "affiliations": [ "Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, 197110 Saint Petersburg, Russia.", "Department of Medical and Biological Disciplines, Belgorod State University, 308015 Belgorod, Russia.", "Department of Therapy, Geriatry, and Anti-Aging Medicine, Academy of Postgraduate Education under FSBU FSCC of FMBA of Russia, 125310 Moscow, Russia.", "Department of the normal physiology, Chita State Medical Academy, 672000 Chita, Russia.", "The Group of Peptide Regulation of Aging, Pavlov Institute of Physiology of RAS, 199034 St. Petersburg, Russia." ] }, { "pmid": "33280326", "year": 2020, "title": "[AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "human", "note": "ECA 40 mujeres trabajo nocturno (versión inglesa Adv Gerontol 2021;11:53-58)", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Ivko OM", "n_authors": 5, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/33280326/", "authors": [ "Ivko OM", "Linkova NS", "Ilina AR", "Sharova AA", "Ryzhak GA" ], "affiliations": [ "Academy of Postgraduate Education, 91 Volokolamskoe shosse, Moscow 125371, Russian Federation.", "Institute of Predictive Medicine, 182 Amathus Ave., Galaxia Sea View, office 3-4, Limassol 3022, Cyprus.", "Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dinamo, St. Petersburg 197110, Russian Federation, e-mail: ibg@gerontology.ru." ] }, { "pmid": "33342107", "year": 2020, "title": "[The influence of AEDG and KE peptides on mitochondries stain and L7A ribosomes protein expression during human pineal gland and thymus cell senescence in vitro.].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Ivko OM", "n_authors": 6, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/33342107/", "authors": [ "Ivko OM", "Drobintseva AO", "Leont'eva DO", "Kvetnoy IM", "Polyakova VO", "Linkova NS" ], "affiliations": [ "Academy of Postgraduate Education, 91 Volokolamskoye shosse, Moscow 125371, Russian Federation.", "Belgorod National Research University, 85 Pobedy str., Belgorod 308009, Russian Federation.", "Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dynamo, St. Petersburg 197110, Russian Federation, e-mail: ibg@gerontology.ru.", "Saint-Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovsky pr., St. Petersburg 191036, Russian Federation.", "Saint-Petersburg State Pediatric Medical University, 2 Litovskaya str., St. Petersburg 194100, Russian Federation.", "Saint-Petersburg State University, 7-9 Universitetskaya nab., St. Petersburg 199034, Russian Federation." ] }, { "pmid": "33526740", "year": 2020, "title": "EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON \"AGED\" HETEROCHROMATIN.", "journal": "Georgian medical news", "journal_abbr": "Georgian Med News", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "in_vitro", "note": "linfocitos humanos", "group": "origin_network", "country": "Georgia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Lezhava T", "n_authors": 6, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/33526740/", "authors": [ "Lezhava T", "Jokhadze T", "Monaselidze J", "Buadze T", "Gaiozishvili M", "Sigua T" ], "affiliations": [ "1Tbilisi State University, Department of Genetics; 2Tbilisi State University, Institute of Genetics; Georgia.", "2Tbilisi State University, Institute of Genetics;3E.Andronikashvili Institute of Physics, Laboratory of Physics, Tbilisi, Georgia." ] }, { "pmid": "33993656", "year": 2021, "title": "[Epigenetic regulation of adaptogenesis by pathology and aging.].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Rubinskii AV", "n_authors": 6, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/33993656/", "authors": [ "Rubinskii AV", "Linkova NS", "Chalisova NI", "Noskin LA", "Marchenko VN", "Khavinson VK" ], "affiliations": [ "Academy of Postgraduate Education under FSBU FSCC of FMBA of Russia, 91 Volocolamskoe shosse, Moscow 125371, Russian Federation.", "B.P.Konstantinov Saint-Petersburg Institute of Nuclear Physic of National Center «Kurchatov Institute », 1 Orlova roshcha, Gatchina, Leningrad region 188300, Russian Federation.", "Belgorod National Research University, 85 Pobedy str., Belgorod 308015, Russian Federation.", "I.P.Pavlov First State Medical Institute, 6-8 Lev Tolstoy str., St. Petersburg 197022, Russian Federation, e-mail: rubinskiyav@1spbgmu.ru.", "I.P.Pavlov Institute of Physiology RAS, 6 Nab. Makarova, St. Petersburg 199034, Russian Federation.", "Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dinamo, St. Petersburg 197110, Russian Federation, e-mail: ibg@gerontology.ru." ] }, { "pmid": "34502859", "year": 2021, "title": "ROBINA: Rotational Orbit-Based Inter-Node Adjustment for Acoustic Routing Path in the Internet of Underwater Things (IoUTs).", "journal": "Sensors (Basel, Switzerland)", "journal_abbr": "Sensors (Basel)", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.3390/s21175968", "substance": "false_positive", "model": "other", "note": "", "group": null, "country": null, "country_source": null, "matched": "epitalon", "first_author": "Draz U", "n_authors": 8, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/34502859/", "authors": [ "Draz U", "Yasin S", "Ali T", "Ali A", "Faheem ZB", "Zhang N", "Jamal MH", "Suh DY" ], "affiliations": [ "College of Electronics and Convergence Engineering, Kyung Hee University, Yongin 446-901, Korea.", "Department of Computer Science, Lahore Campus, CUI, Lahore 54000, Punjab, Pakistan.", "Department of Computer Science, Sahiwal Campus, CUI, Sahiwal 57000, Punjab, Pakistan.", "Department of Computer Science, University of Okara, Okara 56300, Punjab, Pakistan.", "Department of Computer Science, University of Sahiwal, Sahiwal 57000, Punjab, Pakistan.", "Department of Computre Engineering, University of Engineering and Technology, UET, Texila 47080, Punjab, Pakistan.", "Electrical and Computer Engineering, University of Windsor, Windsor, ON N9B 3P4, Canada." ] }, { "pmid": "34998008", "year": 2021, "title": "[Antioxidative properties of geroprotective peptides.].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Kozina LS", "n_authors": 3, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/34998008/", "authors": [ "Kozina LS", "Arutiunov VA", "Arutjanyan AV" ], "affiliations": [ "D.O.Ott Institute of Obstetrics, Gynecology and Reproductology, 3 Mendeleev line, St. Petersburg 199034, Russian Fedration.", "Saint-Petersburg Institute of Bioregulation and Gerontology, 3 Pr. Dynamo, St. Petersburg 197110, Russian Federation, e-mail: milakozina@mail.ru." ] }, { "pmid": "35408963", "year": 2022, "title": "Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.", "journal": "International journal of molecular sciences", "journal_abbr": "Int J Mol Sci", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.3390/ijms23073607", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Avolio F", "n_authors": 16, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/35408963/", "authors": [ "Avolio F", "Martinotti S", "Khavinson VK", "Esposito JE", "Giambuzzi G", "Marino A", "Mironova E", "Pulcini R", "Robuffo I", "Bologna G", "Simeone P", "Lanuti P", "Guarnieri S", "Trofimova S", "Procopio AD", "Toniato E" ], "affiliations": [ "Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, 197110 Saint Petersburg, Russia.", "Department of Clinical and Molecular Sciences, Politecnic University of Marche, 60121 Ancona, Italy.", "Department of Innovative Technology in Medicine and Odontoiatrics, Center of Advanced Studies and Technology University \"G. d'Annunzio\", Chieti-Pescara, 66100 Chieti, Italy.", "Department of Medicine and Aging Sciences, Center of Advanced Studies and Technology University \"G. d'Annunzio\", Chieti-Pescara, 66100 Chieti, Italy.", "Department of Neuroscience, Center of Advanced Studies and Technology, Imaging and Clinical Sciences, University of Chieti, 66100 Chieti, Italy.", "INRCA-IRCCS, Clinic of Laboratory and Precision Medicine, 60121 Ancona, Italy.", "Institute of Molecular Genetics, National Research Council, Section of Chieti, 66100 Chieti, Italy.", "Unicamillus-Saint Unicamillus of Health Science, 00131 Rome, Italy." ] }, { "pmid": "35413689", "year": 2022, "title": "Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro.", "journal": "Aging", "journal_abbr": "Aging (Albany NY)", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.18632/aging.204007", "substance": "epitalon", "model": "in_vitro", "note": "ovocitos ratón", "group": "independent", "country": "China", "country_source": "affiliation", "matched": "epitalon", "first_author": "Yue X", "n_authors": 11, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/35413689/", "authors": [ "Yue X", "Liu SL", "Guo JN", "Meng TG", "Zhang XR", "Li HX", "Song CY", "Wang ZB", "Schatten H", "Sun QY", "Guo XP" ], "affiliations": [ "Department of Biochemistry and Molecular Biology, Basic Medical College, Shanxi Medical University, Taiyuan 030001, Shanxi, China.", "Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA.", "Fertility Preservation Lab, Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou 510320, Guangdong, China.", "Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Reproductive Science Institute, Taiyuan 030032, Shanxi, China.", "State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China." ] }, { "pmid": "35890947", "year": 2022, "title": "A Novel Routing Protocol Based on Elliptical Shaped Movement of Autonomous Underwater Vehicles in Data Gathering Process for Underwater Wireless Sensor Network.", "journal": "Sensors (Basel, Switzerland)", "journal_abbr": "Sensors (Basel)", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.3390/s22145269", "substance": "false_positive", "model": "other", "note": "", "group": null, "country": null, "country_source": null, "matched": "epitalon", "first_author": "Ali G", "n_authors": 9, "mesh_humans": false, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/35890947/", "authors": [ "Ali G", "Ali T", "Hassan IU", "Shaf A", "Irfan M", "Nowakowski G", "Kielkowicz K", "Glowacz A", "Alqhtani SM" ], "affiliations": [ "Department of Automatic Control and Robotics, Faculty of Electrical Engineering, Automatics, Computer Science and Biomedical Engineering, AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Kraków, Poland.", "Department of Computer Science, COMSATS University Islamabad, Sahiwal Campus, Sahiwal 57000, Pakistan.", "Department of Information Systems, College of Computer Science and Information Systems, Najran University, Najran 61441, Saudi Arabia.", "Electrical Engineering Department, College of Engineering, Najran University, Najran 61441, Saudi Arabia.", "Faculty of Electrical and Computer Engineering, Cracow University of Technology, Warszawska 24 Str., 31-155 Cracow, Poland." ] }, { "pmid": "36979488", "year": 2023, "title": "Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters.", "journal": "Biomolecules", "journal_abbr": "Biomolecules", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.3390/biom13030552", "substance": "epitalon", "model": "in_silico", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Khavinson VK", "n_authors": 4, "mesh_humans": false, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/36979488/", "authors": [ "Khavinson VK", "Linkova NS", "Rudskoy AI", "Petukhov MG" ], "affiliations": [ "Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, 197110 Saint Petersburg, Russia.", "Group of Biophysics, Higher Engineering and Technical School, Peter the Great St., Petersburg Polytechnic University, 195251 Saint Petersburg, Russia.", "Group of Peptide Regulation of Aging, Pavlov Institute of Physiology of Russian Academy of Sciences, 199034 Saint Petersburg, Russia.", "Petersburg Nuclear Physics Institute Named after B.P. Konstantinov, NRC \"Kurchatov Institute\", 188300 Gatchina, Russia.", "The Department of Therapy, Geriatrics and Anti-Age Medicine, Academy of Postgraduate Education under of FSBU FSCC of FMBA of Russia, 125371 Moscow, Russia." ] }, { "pmid": "37042594", "year": 2023, "title": "EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON THE \"OLD\" CHROMATIN.", "journal": "Georgian medical news", "journal_abbr": "Georgian Med News", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": null, "substance": "epitalon", "model": "in_vitro", "note": "linfocitos humanos", "group": "origin_network", "country": "Georgia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Lezhava T", "n_authors": 10, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/37042594/", "authors": [ "Lezhava T", "Jokhadze T", "Monaselidze J", "Buadze T", "Gaiozishvili M", "Sigua T", "Khujadze I", "Gogidze K", "Mikaia N", "Chigvinadze N" ], "affiliations": [ "1Department of Genetics, Tbilisi State University, Georgia; 2Institute of Genetics, Tbilisi State University, Georgia.", "3Laboratory of Physics, E. Andronikashvili Institute of Physics, Tbilisi, Georgia." ] }, { "pmid": "38430634", "year": 2024, "title": "A multi-modal approach to investigate Desmodium gangeticum's influence on stress-induced male infertility: In vivo, in vitro, and in silico assessments.", "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie", "journal_abbr": "Biomed Pharmacother", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1016/j.biopha.2024.116358", "substance": "false_positive", "model": "other", "note": "extracto acuoso de D. gangeticum", "group": null, "country": null, "country_source": null, "matched": "epitalon", "first_author": "Alqahtani YS", "n_authors": 10, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/38430634/", "authors": [ "Alqahtani YS", "Chidrawar VR", "Shiromwar S", "Singh S", "Maheshwari R", "Chitme H", "Chilamakuru NB", "Mohite P", "Aljameeli AM", "Khateeb MM" ], "affiliations": [ "AETs St. John Institute of Pharmacy and Research, Palghar, Maharashtra, India.", "Amity Institute of Pharmacy, Amity University, Noida, Uttarpradesh 201303, India.", "Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran 66462, Saudi Arabia.", "Department of Pharmaceutical Chemistry, Raghavendra Institute of Pharmaceutical Education and Research, Anantapur, India.", "Department of Pharmacology, College of Pharmacy, Najran University, Najran 66462, Saudi Arabia.", "Department of Pharmacy Practice, College of Pharmacy, University of Hafar Al-Batin, Saudi Arabia.", "Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), Pulau, Pinang, Malaysia.", "Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Chiang Mai 50200, Thailand.", "School of Pharmacy and Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Deemed-to-university, Green Industrial Park, TSIIC, Jadcherla, Hyderabad 509301, India.", "School of Pharmacy and Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Deemed-to-university, Green Industrial Park, TSIIC, Jadcherla, Hyderabad 509301, India. Electronic address: vijay.chidrawar@nmims.edu." ] }, { "pmid": "39518916", "year": 2024, "title": "Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.", "journal": "International journal of molecular sciences", "journal_abbr": "Int J Mol Sci", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.3390/ijms252111363", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Kraskovskaya N", "n_authors": 9, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/39518916/", "authors": [ "Kraskovskaya N", "Linkova N", "Sakhenberg E", "Krieger D", "Polyakova V", "Medvedev D", "Krasichkov A", "Khotin M", "Ryzhak G" ], "affiliations": [ "Department of Radio Engineering Systems, Saint Petersburg Electrotechnical University 'LETI', 5F Prof. Popova St., St. Petersburg 197376, Russia.", "Institute of Cytology RAS, Tikhoretski Pr., 4, St. Petersburg 194064, Russia.", "St. Petersburg Institute of Bioregulation and Gerontology, 3 Dynamo Ave., St. Petersburg 197110, Russia.", "St. Petersburg Research Institute of Phthisiopulmonology, Ligovskii Pr., 2-4, St. Petersburg 191036, Russia.", "The Department of Social Rehabilitation and Occupational Therapy, St. Petersburg Medical and Social Institute, Kondratievsky St., 72A, St. Petersburg 195271, Russia." ] }, { "pmid": "39742404", "year": 2024, "title": "[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.].", "journal": "Advances in gerontology = Uspekhi gerontologii", "journal_abbr": "Adv Gerontol", "language": [ "rus" ], "pub_types": [ "Journal Article", "Review", "English Abstract" ], "doi": null, "substance": "epitalon", "model": "review", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Ivko OM", "n_authors": 5, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/39742404/", "authors": [ "Ivko OM", "Trofimova SV", "Trofimov AV", "Sharkovich Z", "Mogilev VA" ], "affiliations": [ "Belgorod State National Research University, 85 build. 10 Pobedy str., Belgorod 308015, Russian Federation, e-mail: zlata.sarkovica@gmail.com.", "Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dynamo, St. Petersburg 197110, Russian Federation." ] }, { "pmid": "39788414", "year": 2025, "title": "Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.", "journal": "Life sciences", "journal_abbr": "Life Sci", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1016/j.lfs.2025.123381", "substance": "epitalon", "model": "in_vitro", "note": "ovocitos bovinos", "group": "independent", "country": "South Korea", "country_source": "affiliation", "matched": "epitalon", "first_author": "Ullah S", "n_authors": 7, "mesh_humans": false, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/39788414/", "authors": [ "Ullah S", "Haider Z", "Perera CD", "Lee SH", "Idrees M", "Park S", "Kong IK" ], "affiliations": [ "Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju 52828, Gyeongnam Province, Republic of Korea.", "Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju 52828, Gyeongnam Province, Republic of Korea; Institute of Agriculture and Life Science, Gyeongsang National University, Gyeongnam Province, Republic of Korea. Electronic address: idrees1600@gmail.com.", "Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju 52828, Gyeongnam Province, Republic of Korea; Institute of Agriculture and Life Science, Gyeongsang National University, Gyeongnam Province, Republic of Korea; Division of Animal Science, Gyeongsang National University, Jinju 52828, Republic of Korea; The King Kong Corp. Ltd., Gyeongsang National University, Jinju 52828, Gyeongnam Province, Republic of Korea. Electronic address: ikong7900@gmail.com.", "Institute of Agriculture and Life Science, Gyeongsang National University, Gyeongnam Province, Republic of Korea; Division of Animal Science, Gyeongsang National University, Jinju 52828, Republic of Korea." ] }, { "pmid": "40141333", "year": 2025, "title": "Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.", "journal": "International journal of molecular sciences", "journal_abbr": "Int J Mol Sci", "language": [ "eng" ], "pub_types": [ "Journal Article", "Review" ], "doi": "10.3390/ijms26062691", "substance": "both", "model": "review", "note": "", "group": "independent", "country": "Poland", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Araj SK", "n_authors": 4, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/40141333/", "authors": [ "Araj SK", "Brzezik J", "Mądra-Gackowska K", "Szeleszczuk Ł" ], "affiliations": [ "Department of Geriatrics, Faculty of Health Sciences, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Skłodowskiej Curie 9 Street, 85-094 Bydgoszcz, Poland.", "Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-093 Warsaw, Poland." ] }, { "pmid": "40493162", "year": 2025, "title": "The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.", "journal": "Stem cell reviews and reports", "journal_abbr": "Stem Cell Rev Rep", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1007/s12015-025-10911-x", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Italy", "country_source": "affiliation", "matched": "epitalon", "first_author": "Gatta M", "n_authors": 11, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/40493162/", "authors": [ "Gatta M", "Dovizio M", "Milillo C", "Ruggieri AG", "Sallese M", "Antonucci I", "Trofimov A", "Khavinson V", "Trofimova S", "Bruno A", "Ballerini P" ], "affiliations": [ "Center for Advanced Studies and Technology (CAST), \"G. d'Annunzio\" University of Chieti-Pescara, Chieti, Italy.", "Center for Advanced Studies and Technology (CAST), \"G. d'Annunzio\" University of Chieti-Pescara, Chieti, Italy. a.bruno@unich.it.", "Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg, Russia.", "Department of Cell Biology and Pathology, Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg, Russia.", "Department of Innovative Technologies in Medicine & Dentistry, \"G. d'Annunzio\" University of Chieti-Pescara, Chieti, Italy.", "Department of Innovative Technologies in Medicine & Dentistry, \"G. d'Annunzio\" University of Chieti-Pescara, Chieti, Italy. a.bruno@unich.it.", "Department of Neurosciences, Imaging and Clinical Sciences, \"G. d'Annunzio\" University of Chieti-Pescara, Chieti, Italy." ] }, { "pmid": "40908429", "year": 2025, "title": "Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.", "journal": "Biogerontology", "journal_abbr": "Biogerontology", "language": [ "eng" ], "pub_types": [ "Journal Article", "Research Support, Non-U.S. Gov't" ], "doi": "10.1007/s10522-025-10315-x", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "independent", "country": "United Kingdom", "country_source": "affiliation", "matched": "epitalon", "first_author": "Al-Dulaimi S", "n_authors": 4, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/40908429/", "authors": [ "Al-Dulaimi S", "Thomas R", "Matta S", "Roberts T" ], "affiliations": [ "Centre for Genome Engineering and Maintenance, Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, UK.", "Centre for Genome Engineering and Maintenance, Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, UK. terry.roberts@brunel.ac.uk.", "Respiratory Clinical Research Facility, Royal Brompton Hospital, Fulham Road, London, SW3 6HP, UK." ] }, { "pmid": "41020860", "year": 2025, "title": "The Influence of Short Peptides on Cell Senescence and Neuronal Differentiation.", "journal": "Current issues in molecular biology", "journal_abbr": "Curr Issues Mol Biol", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.3390/cimb47090739", "substance": "epitalon", "model": "in_vitro", "note": "", "group": "origin_group", "country": "Russia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Sakhenberg E", "n_authors": 9, "mesh_humans": false, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/41020860/", "authors": [ "Sakhenberg E", "Linkova N", "Kraskovskaya N", "Krieger D", "Polyakova V", "Medvedev D", "Krasichkov A", "Khotin M", "Ryzhak G" ], "affiliations": [ "Department of Radio Engineering Systems, Electrotechnical University \"LETI\", 5F Prof. Popova St., 197022 St. Petersburg, Russia.", "Institute of Cytology RAS, Tikhoretski Ave., 4, 194064 St. Petersburg, Russia.", "St. Petersburg Institute of Bioregulation and Gerontology, 3 Dynamo Ave., 197110 St. Petersburg, Russia.", "The Department of Hospital Surgery, Belgorod National Research University, 308015 Belgorod, Russia.", "The Department of Social Rehabilitation and Occupational Therapy of the St. Petersburg Medical and Social Institute, Kondratievsky St., 72A, 195271 St. Petersburg, Russia." ] }, { "pmid": "41240216", "year": 2025, "title": "Correction: Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.", "journal": "Biogerontology", "journal_abbr": "Biogerontology", "language": [ "eng" ], "pub_types": [ "Published Erratum" ], "doi": "10.1007/s10522-025-10326-8", "substance": "epitalon", "model": "other", "note": "errata", "group": "independent", "country": "United Kingdom", "country_source": "affiliation", "matched": "epitalon", "first_author": "Al-Dulaimi S", "n_authors": 4, "mesh_humans": false, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/41240216/", "authors": [ "Al-Dulaimi S", "Thomas R", "Matta S", "Roberts T" ], "affiliations": [ "Centre for Genome Engineering and Maintenance, Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, UK.", "Centre for Genome Engineering and Maintenance, Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, UK. terry.roberts@brunel.ac.uk.", "Respiratory Clinical Research Facility, Royal Brompton Hospital, Fulham Road, London, SW3 6HP, UK." ] }, { "pmid": "41490200", "year": 2026, "title": "Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.", "journal": "Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews", "journal_abbr": "J Am Acad Orthop Surg Glob Res Rev", "language": [ "eng" ], "pub_types": [ "Journal Article", "Review" ], "doi": "10.5435/JAAOSGlobal-D-25-00236", "substance": "epitalon", "model": "review", "note": "", "group": "independent", "country": "USA", "country_source": "affiliation", "matched": "epitalon", "first_author": "Rahman OF", "n_authors": 3, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/41490200/", "authors": [ "Rahman OF", "Lee SJ", "Seeds WA" ], "affiliations": [ "From the Pacific Coast Sports Medicine, Los Angeles, CA (Dr. Rahman); Lenox Hill Hospital, New York Orthopedics, New York, NY (Dr. Lee); and the Redox Medical Group, Beverly Hills, CA (Dr. Seeds)." ] }, { "pmid": "42021992", "year": 2026, "title": "Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.", "journal": "Frontiers in aging", "journal_abbr": "Front Aging", "language": [ "eng" ], "pub_types": [ "Journal Article", "Review" ], "doi": "10.3389/fragi.2026.1790247", "substance": "epitalon", "model": "review", "note": "", "group": "independent", "country": "Saudi Arabia", "country_source": "affiliation", "matched": "epitalon", "first_author": "Mavrych V", "n_authors": 3, "mesh_humans": false, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/42021992/", "authors": [ "Mavrych V", "Shypilova I", "Bolgova O" ], "affiliations": [ "College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.", "School of Medicine, St. Matthew's University, George Town, Cayman Islands." ] }, { "pmid": "42209466", "year": 2026, "title": "LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphoma.", "journal": "Cell death & disease", "journal_abbr": "Cell Death Dis", "language": [ "eng" ], "pub_types": [ "Journal Article" ], "doi": "10.1038/s41419-026-08897-6", "substance": "epitalon", "model": "animal", "note": "linfoma, herramienta", "group": "independent", "country": "China", "country_source": "affiliation", "matched": "epitalon", "first_author": "Zhang Y", "n_authors": 12, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/42209466/", "authors": [ "Zhang Y", "Qian S", "Yang Q", "Shi Z", "Dong M", "Wang Z", "Yang Z", "Wu S", "Li Z", "Zhang M", "Zhang X", "Chen Q" ], "affiliations": [ "Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.", "Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. fcczhangxd@zzu.edu.cn.", "Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. qingjiang_c@zzu.edu.cn.", "Henan Academy of Innovations in Medical Science, Zhengzhou, China. qingjiang_c@zzu.edu.cn." ] }, { "pmid": "42752426", "year": 2026, "title": "Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards.", "journal": "International journal of pharmaceutical compounding", "journal_abbr": "Int J Pharm Compd", "language": [ "eng" ], "pub_types": [ "Journal Article", "Review" ], "doi": null, "substance": "epitalon", "model": "review", "note": "regulatoria PCAC", "group": "independent", "country": null, "country_source": null, "matched": "epitalon", "first_author": "Willis J", "n_authors": 2, "mesh_humans": true, "mesh_animals": false, "url": "https://pubmed.ncbi.nlm.nih.gov/42752426/", "authors": [ "Willis J", "Vu N" ], "affiliations": [ "ARL Bio Pharma, Oklahoma City, Oklahoma. Nvu@arlok.com.", "University of Oklahoma College of Pharmacy, Oklahoma City, Oklahoma.", "University of Oklahoma College of Pharmacy." ] }, { "pmid": "42884164", "year": 2026, "title": "Epitalon and Epithalamin: A Narrative Review of Mechanistic, Preclinical, and Clinical Evidence.", "journal": "International journal of molecular sciences", "journal_abbr": "Int J Mol Sci", "language": [ "eng" ], "pub_types": [ "Journal Article", "Review" ], "doi": "10.3390/ijms27198922", "substance": "both", "model": "review", "note": "", "group": "independent", "country": "USA", "country_source": "affiliation", "matched": "epitalon+epithalamin", "first_author": "Jain A", "n_authors": 10, "mesh_humans": true, "mesh_animals": true, "url": "https://pubmed.ncbi.nlm.nih.gov/42884164/", "authors": [ "Jain A", "Gallacher DM", "Issa MA", "Deer TR", "Yong RJ", "Diwan S", "Lee W", "Sayed D", "Amirdelfan K", "Robinson CL" ], "affiliations": [ "Albert Einstein College of Medicine, Bronx, NY 10461, USA.", "Boomerang Healthcare, Walnut Creek, CA 94598, USA.", "Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.", "Department of Anesthesiology, The University of Kansas School of Medicine, Kansas City, MO 66160, USA.", "Department of Anesthesiology, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.", "Department of Physical Medicine and Rehabilitation, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.", "Division of Pain, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.", "Spine and Nerve Center of the Virginias, West Virginia University, Thomas Health Campus, Charleston, WV 25309, USA." ] } ] }